Homo sapiens (human): 3291
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Entry
3291 CDS
T01001
Symbol
HSD11B2, AME, AME1, HSD11K, HSD2, SDR9C3
Name
(RefSeq) hydroxysteroid 11-beta dehydrogenase 2
KO
K00071
corticosteroid 11-beta-dehydrogenase isozyme 2 [EC:1.1.1.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00140
Steroid hormone biosynthesis
hsa01100
Metabolic pathways
hsa04960
Aldosterone-regulated sodium reabsorption
Module
hsa_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Network
nt06019
Steroid hormone biosynthesis
Element
N00338
Steroid hormone biosynthesis, progesterone to cortisol/cortisone
Disease
H00259
Apparent mineralocorticoid excess syndrome
H01633
High blood pressure
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
3291 (HSD11B2)
09150 Organismal Systems
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
3291 (HSD11B2)
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GFIT
Motif
Pfam:
adh_short
adh_short_C2
DUF1776
Motif
Other DBs
NCBI-GeneID:
3291
NCBI-ProteinID:
NP_000187
OMIM:
614232
HGNC:
5209
Ensembl:
ENSG00000176387
Pharos:
P80365
(Tchem)
UniProt:
P80365
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Position
16:67429801..67437553
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AA seq
405 aa
AA seq
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MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
NT seq
1218 nt
NT seq
+upstream
nt +downstream
nt
atggagcgctggccttggccgtcgggcggcgcctggctgctcgtggctgcccgcgcgctg
ctgcagctgctgcgctcagacctgcgtctgggccgcccgctgctggcggcgctggcgctg
ctggccgcgctcgactggctgtgccagcgcctgctgcccccgccggccgcactcgccgtg
ctggccgccgccggctggatcgcgttgtcccgcctggcgcgcccgcagcgcctgccggtg
gccactcgcgcggtgctcatcaccggctgtgactctggttttggcaaggagacggccaag
aaactggactccatgggcttcacggtgctggccaccgtattggagttgaacagccccggt
gccatcgagctgcgtacctgctgctcccctcgcctaaggctgctgcagatggacctgacc
aaaccaggagacattagccgcgtgctagagttcaccaaggcccacaccaccagcaccggc
ctgtggggcctcgtcaacaacgcaggccacaatgaagtagttgctgatgcggagctgtct
ccagtggccactttccgtagctgcatggaggtgaatttctttggcgcgctcgagctgacc
aagggcctcctgcccctgctgcgcagctcaaggggccgcatcgtgactgtggggagccca
gcgggggacatgccatatccgtgcttgggggcctatggaacctccaaagcggccgtggcg
ctactcatggacacattcagctgtgaactccttccctggggggtcaaggtcagcatcatc
cagcctggctgcttcaagacagagtcagtgagaaacgtgggtcagtgggaaaagcgcaag
caattgctgctggccaacctgcctcaagagctgctgcaggcctacggcaaggactacatc
gagcacttgcatgggcagttcctgcactcgctacgcctggccatgtccgacctcacccca
gttgtagatgccatcacagatgcgctgctggcagctcggccccgccgccgctattacccc
ggccagggcctggggctcatgtacttcatccactactacctgcctgaaggcctgcggcgc
cgcttcctgcaggccttcttcatcagtcactgtctgcctcgagcactgcagcctggccag
cctggcactaccccaccacaggacgcagcccaggacccaaacctgagccccggcccttcc
ccagcagtggctcggtga
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