KEGG   Homo sapiens (human): 3295
Entry
3295              CDS       T01001                                 
Symbol
HSD17B4, DBP, MFE-2, MFP-2, MPF-2, PRLTS1, SDR8C1
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 4
  KO
K12405  (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00120  Primary bile acid biosynthesis
hsa01040  Biosynthesis of unsaturated fatty acids
hsa01100  Metabolic pathways
hsa01212  Fatty acid metabolism
hsa04146  Peroxisome
Module
hsa_M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
hsa_M00861  beta-Oxidation, peroxisome, VLCFA
hsa_M00862  beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA
Network
nt06021  beta-Oxidation in peroxisome
nt06022  Bile acid biosynthesis
  Element
N00776  beta-Oxidation, peroxisome, VLCFA
N00779  beta-Oxidation, peroxisome, bile acid
N00805  Bile acid biosynthesis
Disease
H00407  Peroxisomal beta-oxidation enzyme deficiency
H02095  Perrault syndrome
H02098  D-bifunctional protein deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   01040 Biosynthesis of unsaturated fatty acids
    3295 (HSD17B4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    3295 (HSD17B4)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.107  3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase
     3295 (HSD17B4)
    4.2.1.119  enoyl-CoA hydratase 2
     3295 (HSD17B4)
SSDB
Motif
Pfam: MFE-2_hydrat-2_N MaoC_dehydratas adh_short adh_short_C2 SCP2 KR Alkyl_sulf_C FAS1_DH_region AbrB-like
Other DBs
NCBI-GeneID: 3295
NCBI-ProteinID: NP_000405
OMIM: 601860
HGNC: 5213
Ensembl: ENSG00000133835
UniProt: P51659 A0A0S2Z4J1 B2R659
Structure
LinkDB
Position
5:119452497..119542332
AA seq 736 aa
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE
EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH
RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI
EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG
AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS
KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD
LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA
GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV
AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS
ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN
AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI
GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI
MLSQKLQMILKDYAKL
NT seq 2211 nt   +upstreamnt  +downstreamnt
atgggctcaccgctgaggttcgacgggcgggtggtactggtcaccggcgcgggggcagga
ttgggccgagcctatgccctggcttttgcagaaagaggagcgttagttgttgtgaatgat
ttgggaggggacttcaaaggagttggtaaaggctccttagctgctgataaggttgttgaa
gaaataagaaggagaggtggaaaagcagtggccaactatgattcagtggaagaaggagag
aaggttgtgaagacagccctggatgcttttggaagaatagatgttgtggtcaacaatgct
ggaattctgagggatcgttcctttgctaggataagtgatgaagactgggatataatccac
agagttcatttgcggggttcattccaagtgacacgggcagcatgggaacacatgaagaaa
cagaagtatggaaggattattatgacttcatcagcttcaggaatatatggcaactttggc
caggccaattatagtgctgcaaagttgggtcttctgggccttgcaaattctcttgcaatt
gaaggcaggaaaagcaacattcattgtaacaccattgctcctaatgcgggatcacggatg
actcagacagttatgcctgaagatcttgtggaagccctgaagccagagtatgtggcacct
cttgtcctttggctttgtcacgagagttgtgaggagaatggtggcttgtttgaggttgga
gcaggatggattggaaaattacgctgggagcggactcttggagctattgtaagacaaaag
aatcacccaatgactcctgaggcagtcaaggctaactggaagaagatctgtgactttgag
aatgccagcaagcctcagagtatccaagaatcaactggcagtataattgaagttctgagt
aaaatagattcagaaggaggagtttcagcaaatcatactagtcgtgcaacgtctacagca
acatcaggatttgctggagctattggccagaaactccctccattttcttatgcttatacg
gaactggaagctattatgtatgcccttggagtgggagcgtcaatcaaggatccaaaagat
ttgaaatttatttatgaaggaagttctgatttctcctgtttgcccaccttcggagttatc
ataggtcagaaatctatgatgggtggaggattagcagaaattcctggactttcaatcaac
tttgcaaaggttcttcatggagagcagtacttagagttatataaaccacttcccagagca
ggaaaattaaaatgtgaagcagttgttgctgatgtcctagataaaggatccggtgtagtg
attattatggatgtctattcttattctgagaaggaacttatatgccacaatcagttctct
ctctttcttgttggctctggaggctttggtggaaaacggacatcagacaaagtcaaggta
gctgtagccatacctaatagacctcctgatgctgtacttacagataccacctctcttaat
caggctgctttgtaccgcctcagtggagactggaatcccttacacattgatcctaacttt
gctagtctagcaggttttgacaagcccatattacatggattatgtacatttggattttct
gccaggcgtgtgttacagcagtttgcagataatgatgtgtcaagattcaaggcaattaag
gctcgttttgcaaaaccagtatatccaggacaaactctacaaactgagatgtggaaggaa
ggaaacagaattcattttcaaaccaaggtccaagaaactggagacattgtcatttcaaat
gcatatgtggatcttgcaccaacatctggtacttcagctaagacaccctctgagggcggg
aagcttcagagtacctttgtatttgaggaaataggacgccgcctaaaggatattgggcct
gaggtggtgaagaaagtaaatgctgtatttgagtggcatataaccaaaggcggaaatatt
ggggctaagtggactattgacctgaaaagtggttctggaaaagtgtaccaaggccctgca
aaaggtgctgctgatacaacaatcatactttcagatgaagatttcatggaggtggtcctg
ggcaagcttgaccctcagaaggcattctttagtggcaggctgaaggccagagggaacatc
atgctgagccagaaacttcagatgattcttaaagactacgccaagctctga

DBGET integrated database retrieval system