Homo sapiens (human): 3636
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Entry
3636 CDS
T01001
Symbol
INPPL1, OPSMD, SHIP2
Name
(RefSeq) inositol polyphosphate phosphatase like 1
KO
K15909
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:
3.1.3.86
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00562
Inositol phosphate metabolism
hsa01100
Metabolic pathways
hsa04070
Phosphatidylinositol signaling system
hsa04662
B cell receptor signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa04910
Insulin signaling pathway
Disease
H01828
Opsismodysplasia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
3636 (INPPL1)
09130 Environmental Information Processing
09132 Signal transduction
04070 Phosphatidylinositol signaling system
3636 (INPPL1)
09150 Organismal Systems
09151 Immune system
04662 B cell receptor signaling pathway
3636 (INPPL1)
04666 Fc gamma R-mediated phagocytosis
3636 (INPPL1)
09152 Endocrine system
04910 Insulin signaling pathway
3636 (INPPL1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
3636 (INPPL1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
3636 (INPPL1)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Clathrin-mediated endocytosis
Inositol 5-phosphatases
3636 (INPPL1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Exo_endo_phos2
C2_SHIP1-2_2nd
C2_SHIP1-2_first
SH2
SAM_1
SAM_2
SAM_TNK
Motif
Other DBs
NCBI-GeneID:
3636
NCBI-ProteinID:
NP_001558
OMIM:
600829
HGNC:
6080
Ensembl:
ENSG00000165458
UniProt:
O15357
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:72223563..72239147
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AA seq
1258 aa
AA seq
DB search
MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS
SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS
TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT
HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE
PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE
WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN
KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT
HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT
YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP
VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS
FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA
LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS
KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR
LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT
VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR
GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP
ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG
MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
NT seq
3777 nt
NT seq
+upstream
nt +downstream
nt
atggcctcggcctgcggggcgccgggcccggggggcgccctgggcagccaggccccctcc
tggtaccaccgcgacctgagccgggcggccgcggaggagctgctggcccgggcgggccgc
gatggcagcttcctggtccgagacagcgagagcgtggcgggggccttcgcgctctgcgtc
ctgtatcagaagcatgtgcacacgtatcgcattctgcctgatggagaagatttcttggct
gtgcagacctcgcagggtgtgcctgtgcgccgcttccagaccctgggtgagctcatcggc
ctgtacgcccagcccaaccagggccttgtgtgcgccctgcttcttcctgtagagggtgag
cgagagccggacccaccggatgaccgggatgcctcagatggggaggatgagaagcccccg
ctgcccccgcgctctggctccaccagcatttctgcccccactgggcccagcagtcccctg
ccagctcctgagactcccacagctccagctgctgagagtgctcccaatgggctgagcacc
gtctcgcacgactacctgaaaggcagctatgggctggacctggaagctgtgaggggtgga
gccagccacctgccccacctcacccgtaccctcgctacctcatgccggaggctgcacagt
gaggtggacaaggtcctgtcaggcctggagatcctgtccaaggtgtttgaccagcagagc
tcgcccatggtgacccgccttttgcagcagcagaacctgccacagacaggggagcaggaa
ctagagagcctggtgctgaagctgtcagtgctaaaggacttcctgtcaggcatccagaag
aaggccctgaaggccctacaggacatgagctccacagcacccccagctccgcagccatcc
acacgtaaggccaagaccatccccgtgcaggcctttgaggtgaagctagatgtgaccctg
ggtgacctgaccaagattgggaagtcacagaagttcacgctgagcgtggatgtggagggt
gggcggctggtgctgctgcggagacagcgggactcccaggaggactggaccaccttcacg
cacgaccgcatccgccagctcattaagtcccagcgtgtccagaacaagctgggtgttgtg
tttgagaaggagaaggaccggactcagcgcaaggacttcatctttgtcagtgcccggaag
cgggaggccttctgccagctgttgcagctcatgaagaacaagcactccaagcaggacgag
cccgacatgatctcagtcttcataggcacctggaacatgggaagtgtaccacctccaaaa
aacgtgacatcctggttcacatcgaagggtctggggaagaccctggacgaggtcacagtg
accataccccatgacatctatgtctttgggacccaggagaactcagtgggcgaccgcgag
tggctggacctactgcgcgggggcctcaaggagcttacggatctggattaccgcccgatt
gccatgcaatcactgtggaatatcaaggtggcagtgctggtcaagccagagcacgagaac
cgtatcagccatgtcagtacgtccagtgtgaagactggcatcgccaacaccctggggaac
aagggggctgtgggcgtctccttcatgtttaatggcacctcatttggctttgtgaattgt
cacctcacctcgggaaatgagaagacggctcggaggaaccaaaactacttggacatcctg
cggctgctctcgctgggcgaccggcagctcaatgcctttgacatctctctgcgtttcaca
cacctcttctggtttggggacctcaactaccgcctggacatggatatccaggagatcctg
aactacatcagcaggaaagagtttgagcccctcctcagggtggaccagctcaacctggag
cgggagaagcacaaggtcttccttcgattcagtgaggaggagatctccttcccacccacc
taccgctatgagcggggttcccgggacacatatgcctggcacaagcagaagccaactggg
gtccggaccaatgtgccctcatggtgtgaccggattctgtggaaatcctaccctgaaact
cacatcatctgcaattcttatggttgcactgatgacatcgtcaccagcgaccattccccc
gtgtttgggacatttgaggttggagttacctcccagttcatctccaagaaagggctctca
aagacttcagaccaggcctacattgagtttgagagcatcgaggccattgtgaagacagcc
agccgcaccaagttcttcatcgagttctactctacctgcctggaggaatacaagaagagc
tttgagaatgatgcccagagcagtgacaacatcaacttcctcaaagtgcagtggtcttca
cgccagctgcccacgctcaaaccaattctggctgatatcgagtacctgcaggaccagcac
ctcctgctcacagtcaagtccatggatggctatgaatcctatggggagtgtgtggttgca
ctcaaatccatgatcggcagcacggcccaacagttcctgaccttcctatcccaccgtggc
gaggagacaggcaatatcagaggctccatgaaggtgcgggtgcccacggagcgcctgggc
acccgtgagcggctctacgagtggatcagcattgataaggatgaggcaggagcaaagagc
aaagccccctctgtgtcccgagggagccaggagcccaggtcagggagccgcaagccagcc
ttcacagaggcctcctgcccgctctccaggttatttgaagaaccagagaaaccgccacca
acggggaggcccccagccccaccccgagcagctccccgggaggagcccttgacccccagg
ttgaagccagagggagctcctgaaccagaaggggtggcggcccccccacccaagaacagc
ttcaataaccctgcctactacgtccttgaaggggtcccgcaccagctgctgcccccggag
ccaccctcgcctgccagggcccctgtcccatctgccaccaagaacaaagtggccattaca
gtgcctgctccacagcttgggcaccaccggcaccctcgtgtgggagaggggagttcttca
gatgaggagtctggaggcacactgccccctccagactttccacctccaccactgccggac
tcagccatcttcctgccccccagcctggatcctttaccagggccagtggtccggggccgt
ggtggggctgaggcccgtggcccaccacctcccaaggcccatccaaggcctccactgccc
ccaggcccctcaccagccagcactttcctgggggaagtggccagtggggatgaccggtcc
tgctcggtgctgcagatggccaagacgctgagcgaggtggactatgcccctgctgggcct
gcacgctcagcgctcctcccaggccccctggagctgcagcccccccggggactgccctcg
gactatggccggcccctcagcttccctccaccccgcatccgggagagcatccaggaagac
ctggcagaggaggctccgtgcctgcagggcgggcgggccagcgggctgggcgaggcaggc
atgagtgcctggctgcgggccatcggcttggagcgctatgaggagggcctggtgcataat
ggctgggacgacctggagtttctcagtgacatcaccgaggaggacttggaggaggctggg
gtgcaggacccggctcacaagcgcctccttctggacaccctgcagctcagcaagtga
DBGET
integrated database retrieval system
