KEGG   NETWORK: N01967
Entry
N01967                      Network                                
Name
SLAMF interactions
Definition
SLAMF == SLAMF -> ((SH2D1A,SH2D1B)+(FYN,LCK)),(SHIP,DOK,RASGAP))
  Expanded
(6504,962,4063,51744,8832,114836,57823) == (6504,962,4063,51744,8832,114836,57823) -> ((4068,117157)+(2534,3932)),((3635,3636),(1796,9046),5921)
Class
nt06546 IgSF CAM signaling
Type
Reference
Pathway
hsa04517 IGSF CAM signaling   
Gene
6504  SLAMF1; signaling lymphocytic activation molecule family member 1
962  CD48; CD48 molecule
4063  LY9; lymphocyte antigen 9
51744  CD244; CD244 molecule
8832  CD84; CD84 molecule
114836  SLAMF6; SLAM family member 6
57823  SLAMF7; SLAM family member 7
4068  SH2D1A; SH2 domain containing 1A
117157  SH2D1B; SH2 domain containing 1B
2534  FYN; FYN proto-oncogene, Src family tyrosine kinase
3932  LCK; LCK proto-oncogene, Src family tyrosine kinase
3635  INPP5D; inositol polyphosphate-5-phosphatase D
3636  INPPL1; inositol polyphosphate phosphatase like 1
1796  DOK1; docking protein 1
9046  DOK2; docking protein 2
5921  RASA1; RAS p21 protein activator 1
Reference
  Authors
Farhangnia P, Ghomi SM, Mollazadehghomi S, Nickho H, Akbarpour M, Delbandi AA
  Title
SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy.
  Journal
Front Immunol 14:1174138 (2023)
DOI:10.3389/fimmu.2023.1174138
Reference
  Authors
Li J, Fan T, Wang D, Xiao C, Deng Z, Cai W, Ji Y, Li C, He J
  Title
SLAMF receptors: key regulators of tumor progression and emerging targets for cancer immunotherapy.
  Journal
Mol Cancer 24:145 (2025)
DOI:10.1186/s12943-025-02308-8
Reference
  Authors
Ishibashi M, Morita R, Tamura H
  Title
Immune Functions of Signaling Lymphocytic Activation Molecule Family Molecules in Multiple Myeloma.
  Journal
Cancers (Basel) 13:cancers13020279 (2021)
DOI:10.3390/cancers13020279
Reference
  Authors
Schwartzberg PL, Mueller KL, Qi H, Cannons JL
  Title
SLAM receptors and SAP influence lymphocyte interactions, development and function.
  Journal
Nat Rev Immunol 9:39-46 (2009)
DOI:10.1038/nri2456
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