KEGG   Homo sapiens (human): 3681
Entry
3681              CDS       T01001                                 
Symbol
ITGAD, ADB2, CD11D
Name
(RefSeq) integrin subunit alpha D
  KO
K06594  integrin alpha D
Organism
hsa  Homo sapiens (human)
Pathway
hsa04518  Integrin signaling
hsa04810  Regulation of actin cytoskeleton
Network
nt06548  Integrin signaling
  Element
N01977  Integrin alphaDbeta2 signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    3681 (ITGAD)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3681 (ITGAD)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules [BR:hsa04515]
    3681 (ITGAD)
   04090 CD molecules [BR:hsa04090]
    3681 (ITGAD)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin alpha subunits
   3681 (ITGAD)
CD molecules [BR:hsa04090]
 Proteins
  3681 (ITGAD)
SSDB
Motif
Pfam: ITGAX-like_Ig_3 VWA FG-GAP Integrin_A_Ig_2 VWA_2 Integrin_A_Ig_1 FG-GAP_3 Integrin_alpha Integrin_A_Ig_3 DUF3866
Other DBs
NCBI-GeneID: 3681
NCBI-ProteinID: NP_005344
OMIM: 602453
HGNC: 6146
Ensembl: ENSG00000156886
UniProt: Q13349 Q59H14
LinkDB
Position
16:31393335..31426505
AA seq 1161 aa
MTFGTVLLLSVLASYHGFNLDVEEPTIFQEDAGGFGQSVVQFGGSRLVVGAPLEVVAANQ
TGRLYDCAAATGMCQPIPLHIRPEAVNMSLGLTLAASTNGSRLLACGPTLHRVCGENSYS
KGSCLLLGSRWEIIQTVPDATPECPHQEMDIVFLIDGSGSIDQNDFNQMKGFVQAVMGQF
EGTDTLFALMQYSNLLKIHFTFTQFRTSPSQQSLVDPIVQLKGLTFTATGILTVVTQLFH
HKNGARKSAKKILIVITDGQKYKDPLEYSDVIPQAEKAGIIRYAIGVGHAFQGPTARQEL
NTISSAPPQDHVFKVDNFAALGSIQKQLQEKIYAVEGTQSRASSSFQHEMSQEGFSTALT
MDGLFLGAVGSFSWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQNLV
LGAPRYQHTGKAVIFTQVSRQWRKKAEVTGTQIGSYFGASLCSVDVDSDGSTDLILIGAP
HYYEQTRGGQVSVCPLPRGRVQWQCDAVLRGEQGHPWGRFGAALTVLGDVNEDKLIDVAI
GAPGEQENRGAVYLFHGASESGISPSHSQRIASSQLSPRLQYFGQALSGGQDLTQDGLMD
LAVGARGQVLLLRSLPVLKVGVAMRFSPVEVAKAVYRCWEEKPSALEAGDATVCLTIQKS
SLDQLGDIQSSVRFDLALDPGRLTSRAIFNETKNPTLTRRKTLGLGIHCETLKLLLPDCV
EDVVSPIILHLNFSLVREPIPSPQNLRPVLAVGSQDLFTASLPFEKNCGQDGLCEGDLGV
TLSFSGLQTLTVGSSLELNVIVTVWNAGEDSYGTVVSLYYPAGLSHRRVSGAQKQPHQSA
LRLACETVPTEDEGLRSSRCSVNHPIFHEGSNGTFIVTFDVSYKATLGDRMLMRASASSE
NNKASSSKATFQLELPVKYAVYTMISRQEESTKYFNFATSDEKKMKEAEHRYRVNNLSQR
DLAISINFWVPVLLNGVAVWDVVMEAPSQSLPCVSERKPPQHSDFLTQISRSPMLDCSIA
DCLQFRCDVPSFSVQEELDFTLKGNLSFGWVRETLQKKVLVVSVAEITFDTSVYSQLPGQ
EAFMRAQMEMVLEEDEVYNAIPIIMGSSVGALLLLALITATLYKLGFFKRHYKEMLEDKP
EDTATFSGDDFSCVAPNVPLS
NT seq 3486 nt   +upstreamnt  +downstreamnt
atgaccttcggcactgtgcttcttctgagtgtcctggcttcttatcatggattcaacctg
gatgtggaggagcctacgatcttccaggaggatgcaggcggctttgggcagagcgtggtg
cagttcggtggatctcgactcgtggtgggagcacccctggaggtggtggcggccaaccag
acgggacggctgtatgactgcgcagctgccaccggcatgtgccagcccatcccgctgcac
atccgccctgaggccgtgaacatgtccttgggcctgaccctggcagcctccaccaacggc
tcccggctcctggcctgtggcccgaccctgcacagagtctgtggggagaactcatactca
aagggttcctgcctcctgctgggctcgcgctgggagatcatccagacagtccccgacgcc
acgccagagtgtccacatcaagagatggacatcgtcttcctgattgacggctctggaagc
attgaccaaaatgactttaaccagatgaagggctttgtccaagctgtcatgggccagttt
gagggcactgacaccctgtttgcactgatgcagtactcaaacctcctgaagatccacttc
accttcacccaattccggaccagcccgagccagcagagcctggtggatcccatcgtccaa
ctgaaaggcctgacgttcacggccacgggcatcctgacagtggtgacacagctatttcat
cataagaatggggcccgaaaaagtgccaagaagatcctcattgtcatcacagatgggcag
aagtacaaagaccccctggaatacagtgatgtcatcccccaggcagagaaggctggcatc
atccgctacgctatcggggtgggacacgctttccagggacccactgccaggcaggagctg
aataccatcagctcagcgcctccgcaggaccacgtgttcaaggtggacaactttgcagcc
cttggcagcatccagaagcagctgcaggagaagatctatgcagttgagggaacccagtcc
agggcaagcagctccttccagcacgagatgtcccaagaaggcttcagcacagccctcaca
atggatggcctcttcctgggggctgtggggagctttagctggtctggaggtgccttcctg
tatcccccaaatatgagccccaccttcatcaacatgtctcaggagaatgtggacatgagg
gactcttacctgggttactccaccgagctagccctgtggaagggggtacagaacctggtc
ctgggggccccccgctaccagcataccgggaaggctgtcatcttcacccaggtgtccagg
caatggaggaagaaggccgaagtcacagggacgcagatcggctcctacttcggggcctcc
ctctgctctgtggatgtggacagcgatggcagcaccgacctgatcctcattggggccccc
cattactatgagcagacccgagggggccaggtgtccgtgtgtcccttgcctagggggagg
gtgcagtggcagtgtgacgctgttctccgtggtgagcagggccacccctggggccgcttt
ggggcagccctgacagtgttgggggatgtgaatgaggacaagctgatagacgtggccatt
ggggccccgggagagcaggagaaccggggtgctgtctacctgtttcacggagcctcagaa
tccggcatcagcccctcccacagccagcggattgccagctcccagctctcccccaggctg
cagtattttgggcaggcgctgagtgggggtcaggacctcacccaggatggactgatggac
ctggccgtgggggcccggggccaggtgctcctgctcaggagtctgccggtgctgaaagtg
ggggtggccatgagattcagccctgtggaggtggccaaggctgtgtaccggtgctgggaa
gagaagcccagtgccctggaagctggggacgccaccgtctgtctcaccatccagaaaagc
tcactggaccagctaggtgacatccaaagctctgtcaggtttgatctggcactggaccca
ggtcgtctgacttctcgtgccattttcaatgaaaccaagaaccccactttgactcgaaga
aaaaccctgggactggggattcactgtgaaaccctgaagctgcttttgccagattgtgtg
gaggatgtggtgagccccatcattctgcacctcaacttctcactggtgagagagcccatc
ccctccccccagaacctgcgtcctgtgctggccgtgggctcacaagacctcttcactgct
tctctccccttcgagaagaactgtgggcaagatggcctctgtgaaggggacctgggtgtc
accctcagcttctcaggcctgcagaccctgaccgtggggagctccctggagctcaacgtg
attgtgactgtgtggaacgcaggtgaggattcctacggaaccgtggtcagcctctactat
ccagcagggctgtcgcaccgacgggtgtcaggagcccagaagcagccccatcagagtgcc
ctgcgcctggcatgtgagacagtgcccactgaggatgagggcctaagaagcagccgctgc
agtgtcaaccaccccatcttccatgagggctctaacggcaccttcatagtcacattcgat
gtctcctacaaggccaccctgggagacaggatgcttatgagggccagtgcaagcagtgag
aacaataaggcttcaagcagcaaggccaccttccagctggagctcccggtgaagtatgca
gtctacaccatgatcagcaggcaggaagaatccaccaagtacttcaactttgcaacctcc
gatgagaagaaaatgaaagaggctgagcatcgataccgtgtgaataacctcagccagcga
gatctggccatcagcattaacttctgggttcctgtcctgctgaacggggtggctgtgtgg
gatgtggtcatggaggccccatctcagagtctcccctgtgtttcagagagaaaacctccc
cagcattctgacttcctgacccagatttcaagaagtcccatgctggactgctccattgct
gactgcctgcagttccgctgtgacgtcccctccttcagcgtccaggaggagctggatttc
accctgaagggcaatctcagtttcggctgggtccgcgagacattgcagaagaaggtgttg
gtcgtgagtgtggctgaaattacgttcgacacatccgtgtactcccagcttccaggacag
gaggcatttatgagagctcagatggagatggtgctagaagaagacgaggtctacaatgcc
attcccatcatcatgggcagctctgtgggggctctgctactgctggcgctcatcacagcc
acactgtacaagcttggcttcttcaaacgccactacaaggaaatgctggaggacaagcct
gaagacactgccacattcagtggggacgatttcagctgtgtggccccaaatgtgcctttg
tcctaa

KEGG   Homo sapiens (human): 3689
Entry
3689              CDS       T01001                                 
Symbol
ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Name
(RefSeq) integrin subunit beta 2
  KO
K06464  integrin beta 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04390  Hippo signaling pathway
hsa04514  Cell adhesion molecule (CAM) interaction
hsa04517  IgSF CAM signaling
hsa04518  Integrin signaling
hsa04610  Complement and coagulation cascades
hsa04613  Neutrophil extracellular trap formation
hsa04650  Natural killer cell mediated cytotoxicity
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05144  Malaria
hsa05146  Amoebiasis
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05166  Human T-cell leukemia virus 1 infection
hsa05323  Rheumatoid arthritis
hsa05416  Viral myocarditis
Network
nt06546  IgSF CAM signaling
nt06548  Integrin signaling
  Element
N01956  JAM1 interactions
N01958  JAM3 interactions
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
N01975  Integrin alphaLbeta2 signaling
N01976  Integrin alphaMbeta2 signaling
N01977  Integrin alphaDbeta2 signaling
N01998  Integrin alphaXbeta2 signaling
Disease
H00099  Leukocyte adhesion deficiency
Drug target
Erlizumab: D04045
Fuzapladib sodium hydrate: D11919
Rovelizumab: D08993
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3689 (ITGB2)
   04390 Hippo signaling pathway
    3689 (ITGB2)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecule (CAM) interaction
    3689 (ITGB2)
   04517 IgSF CAM signaling
    3689 (ITGB2)
   04518 Integrin signaling
    3689 (ITGB2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3689 (ITGB2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3689 (ITGB2)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    3689 (ITGB2)
   04613 Neutrophil extracellular trap formation
    3689 (ITGB2)
   04650 Natural killer cell mediated cytotoxicity
    3689 (ITGB2)
   04670 Leukocyte transendothelial migration
    3689 (ITGB2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3689 (ITGB2)
  09171 Infectious disease: bacterial
   05133 Pertussis
    3689 (ITGB2)
   05134 Legionellosis
    3689 (ITGB2)
   05150 Staphylococcus aureus infection
    3689 (ITGB2)
   05152 Tuberculosis
    3689 (ITGB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3689 (ITGB2)
   05144 Malaria
    3689 (ITGB2)
   05140 Leishmaniasis
    3689 (ITGB2)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3689 (ITGB2)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3689 (ITGB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3689 (ITGB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3689 (ITGB2)
   04515 Cell adhesion molecules [BR:hsa04515]
    3689 (ITGB2)
   04090 CD molecules [BR:hsa04090]
    3689 (ITGB2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    3689 (ITGB2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3689 (ITGB2)
Cell adhesion molecules [BR:hsa04515]
 Integrins
  Integrin beta subunits
   3689 (ITGB2)
CD molecules [BR:hsa04090]
 Proteins
  3689 (ITGB2)
SSDB
Motif
Pfam: Integrin_beta EGF_integrin Integrin_B_tail Integrin_b_cyt PSI_integrin I-EGF_1 EGF_2 vWA_SIBA-E
Other DBs
NCBI-GeneID: 3689
NCBI-ProteinID: NP_000202
OMIM: 600065
HGNC: 6155
Ensembl: ENSG00000160255
UniProt: P05107 A0A494C0X7
Structure
LinkDB
Position
21:complement(44885953..44928815)
AA seq 769 aa
MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSI
RCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFR
RAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFV
NTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAM
MQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFD
YPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVHLIKNAY
NKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATEC
IQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKN
CECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTIN
CERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNV
CECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGR
TCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLL
VIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
NT seq 2310 nt   +upstreamnt  +downstreamnt
atgctgggcctgcgccccccactgctcgccctggtggggctgctctccctcgggtgcgtc
ctctctcaggagtgcacgaagttcaaggtcagcagctgccgggaatgcatcgagtcgggg
cccggctgcacctggtgccagaagctgaacttcacagggccgggggatcctgactccatt
cgctgcgacacccggccacagctgctcatgaggggctgtgcggctgacgacatcatggac
cccacaagcctcgctgaaacccaggaagaccacaatgggggccagaagcagctgtcccca
caaaaagtgacgctttacctgcgaccaggccaggcagcagcgttcaacgtgaccttccgg
cgggccaagggctaccccatcgacctgtactatctgatggacctctcctactccatgctt
gatgacctcaggaatgtcaagaagctaggtggcgacctgctccgggccctcaacgagatc
accgagtccggccgcattggcttcgggtccttcgtggacaagaccgtgctgccgttcgtg
aacacgcaccctgataagctgcgaaacccatgccccaacaaggagaaagagtgccagccc
ccgtttgccttcaggcacgtgctgaagctgaccaacaactccaaccagtttcagaccgag
gtcgggaagcagctgatttccggaaacctggatgcacccgagggtgggctggacgccatg
atgcaggtcgccgcctgcccggaggaaatcggctggcgcaacgtcacgcggctgctggtg
tttgccactgatgacggcttccatttcgcgggcgacgggaagctgggcgccatcctgacc
cccaacgacggccgctgtcacctggaggacaacttgtacaagaggagcaacgaattcgac
tacccatcggtgggccagctggcgcacaagctggctgaaaacaacatccagcccatcttc
gcggtgaccagtaggatggtgaagacctacgagaaactcaccgagatcatccccaagtca
gccgtgggggagctgtctgaggactccagcaatgtggtccatctcattaagaatgcttac
aataaactctcctccagggtcttcctggatcacaacgccctccccgacaccctgaaagtc
acctacgactccttctgcagcaatggagtgacgcacaggaaccagcccagaggtgactgt
gatggcgtgcagatcaatgtcccgatcaccttccaggtgaaggtcacggccacagagtgc
atccaggagcagtcgtttgtcatccgggcgctgggcttcacggacatagtgaccgtgcag
gttcttccccagtgtgagtgccggtgccgggaccagagcagagaccgcagcctctgccat
ggcaagggcttcttggagtgcggcatctgcaggtgtgacactggctacattgggaaaaac
tgtgagtgccagacacagggccggagcagccaggagctggaaggaagctgccggaaggac
aacaactccatcatctgctcagggctgggggactgtgtctgcgggcagtgcctgtgccac
accagcgacgtccccggcaagctgatatacgggcagtactgcgagtgtgacaccatcaac
tgtgagcgctacaacggccaggtctgcggcggcccggggagggggctctgcttctgcggg
aagtgccgctgccacccgggctttgagggctcagcgtgccagtgcgagaggaccactgag
ggctgcctgaacccgcggcgtgttgagtgtagtggtcgtggccggtgccgctgcaacgta
tgcgagtgccattcaggctaccagctgcctctgtgccaggagtgccccggctgcccctca
ccctgtggcaagtacatctcctgcgccgagtgcctgaagttcgaaaagggcccctttggg
aagaactgcagcgcggcgtgtccgggcctgcagctgtcgaacaaccccgtgaagggcagg
acctgcaaggagagggactcagagggctgctgggtggcctacacgctggagcagcaggac
gggatggaccgctacctcatctatgtggatgagagccgagagtgtgtggcaggccccaac
atcgccgccatcgtcgggggcaccgtggcaggcatcgtgctgatcggcattctcctgctg
gtcatctggaaggctctgatccacctgagcgacctccgggagtacaggcgctttgagaag
gagaagctcaagtcccagtggaacaatgataatccccttttcaagagcgccaccacgacg
gtcatgaaccccaagtttgctgagagttag

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