Homo sapiens (human): 3702
Help
Entry
3702 CDS
T01001
Symbol
ITK, EMT, LPFS1, LYK, PSCTK2
Name
(RefSeq) IL2 inducible T cell kinase
KO
K07363
IL2-inducible T-cell kinase [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04062
Chemokine signaling pathway
hsa04660
T cell receptor signaling pathway
hsa04670
Leukocyte transendothelial migration
Disease
H00107
Other well-defined immunodeficiency syndromes
H01970
Lymphoproliferative syndrome
Drug target
Soquelitinib:
D12762
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04660 T cell receptor signaling pathway
3702 (ITK)
04670 Leukocyte transendothelial migration
3702 (ITK)
04062 Chemokine signaling pathway
3702 (ITK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
3702 (ITK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
3702 (ITK)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
TEC family
3702 (ITK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
PH
SH3_1
BTK
SH3_9
SH3_10
SH3_2
PH_8
SH3_3
ABC1
SH3_4
Motif
Other DBs
NCBI-GeneID:
3702
NCBI-ProteinID:
NP_005537
OMIM:
186973
HGNC:
6171
Ensembl:
ENSG00000113263
UniProt:
Q08881
Structure
PDB
PDBj
LinkDB
All DBs
Position
5:157180840..157255185
Genome browser
AA seq
620 aa
AA seq
DB search
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
NT seq
1863 nt
NT seq
+upstream
nt +downstream
nt
atgaacaactttatcctcctggaagaacagctcatcaagaaatcccaacaaaagagaaga
acttctccctcgaactttaaagtccgcttctttgtgttaaccaaagccagcctggcatac
tttgaagatcgtcatgggaagaagcgcacgctgaaggggtccattgagctctcccgaatc
aaatgtgttgagattgtgaaaagtgacatcagcatcccatgccactataaatacccgttt
caggtggtgcatgacaactacctcctatatgtgtttgctccagatcgtgagagccggcag
cgctgggtgctggcccttaaagaagaaacgaggaataataacagtttggtgcctaaatat
catcctaatttctggatggatgggaagtggaggtgctgttctcagctggagaagcttgca
acaggctgtgcccaatatgatccaaccaagaatgcttcaaagaagcctcttcctcctact
cctgaagacaacaggcgaccactttgggaacctgaagaaactgtggtcattgccttatat
gactaccaaaccaatgatcctcaggaactcgcactgcggcgcaacgaagagtactgcctg
ctggacagttctgagattcactggtggagagtccaggacaggaatgggcatgaaggatat
gtaccaagcagttatctggtggaaaaatctccaaataatctggaaacctatgagtggtac
aataagagtatcagccgagacaaagctgaaaaacttcttttggacacaggcaaagaagga
gccttcatggtaagggattccaggactgcaggaacatacaccgtgtctgttttcaccaag
gctgttgtaagtgagaacaatccctgtataaagcattatcacatcaaggaaacaaatgac
aatcctaagcgatactatgtggctgaaaagtatgtgttcgattccatccctcttctcatc
aactatcaccaacataatggaggaggcctggtgactcgactccggtatccagtttgtttt
gggaggcagaaagccccagttacagcagggctgagatacgggaaatgggtgatcgacccc
tcagagctcacttttgtgcaagagattggcagtgggcaatttgggttggtgcatctgggc
tactggctcaacaaggacaaggtggctatcaaaaccattcgggaaggggctatgtcagaa
gaggacttcatagaggaggctgaagtaatgatgaaactctctcatcccaaactggtgcag
ctgtatggggtgtgcctggagcaggcccccatctgcctggtgtttgagttcatggagcac
ggctgcctgtcagattatctacgcacccagcggggactttttgctgcagagaccctgctg
ggcatgtgtctggatgtgtgtgagggcatggcctacctggaagaggcatgtgtcatccac
agagacttggctgccagaaattgtttggtgggagaaaaccaagtcatcaaggtgtctgac
tttgggatgacaaggttcgttctggatgatcagtacaccagttccacaggcaccaaattc
ccggtgaagtgggcatccccagaggttttctctttcagtcgctatagcagcaagtccgat
gtgtggtcatttggtgtgctgatgtgggaagttttcagtgaaggcaaaatcccgtatgaa
aaccgaagcaactcagaggtggtggaagacatcagtaccggatttcggttgtacaagccc
cggctggcctccacacacgtctaccagattatgaatcactgctggaaagagagaccagaa
gatcggccagccttctccagactgctgcgtcaactggctgaaattgcagaatcaggactt
tag
Homo sapiens (human): 7294
Help
Entry
7294 CDS
T01001
Symbol
TXK, BTKL, PSCTK5, PTK4, RLK, TKL
Name
(RefSeq) TXK tyrosine kinase
KO
K08016
tyrosine-protein kinase TXK [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04670
Leukocyte transendothelial migration
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
7294 (TXK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
7294 (TXK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
7294 (TXK)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
TEC family
7294 (TXK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_9
SH2_1
ABC1
SH3_10
SH3_2
Motif
Other DBs
NCBI-GeneID:
7294
NCBI-ProteinID:
NP_003319
OMIM:
600058
HGNC:
12434
Ensembl:
ENSG00000074966
UniProt:
P42681
Structure
PDB
PDBj
LinkDB
All DBs
Position
4:complement(48066393..48134250)
Genome browser
AA seq
527 aa
AA seq
DB search
MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
NT seq
1584 nt
NT seq
+upstream
nt +downstream
nt
atgatcctttcctcctataacaccatccagtcggttttctgttgctgctgttgctgttca
gtgcagaagcgacaaatgagaacacagataagcctgagcacagatgaagagcttccagaa
aaatacacccagcgtcgcaggccgtggctcagccaattgtcaaataagaagcaatccaac
acgggccgtgtgcagccgtcaaaacgaaagccactgcctcccctcccaccctctgaggtt
gctgaagagaagatccaagtcaaggcactttatgattttctgcccagagaaccctgtaat
ttagccttaaggagagcagaagaatacctgatactggagaaatacaatcctcactggtgg
aaggcaagagaccgtttggggaatgaaggcttaatcccaagcaactatgtgactgaaaac
aaaataactaatttagaaatatatgagtggtaccatagaaacattaccagaaatcaggca
gaacatctattgagacaagagtctaaagaaggtgcatttattgtcagagattcaagacat
ttaggatcctacacaatttccgtatttatgggagctagaagaagtacggaggctgccata
aaacattatcagataaaaaagaatgactcaggacagtggtatgtggctgaaagacacgcc
tttcaatcaatccctgagttaatctggtatcaccagcacaatgcagccggtctcatgact
cgtctccgatatccagttgggctgatgggcagttgtttaccagccacagctgggtttagc
tacgaaaagtgggagatagatccatctgagttggcttttataaaggagattggaagcggt
cagtttggagtggtccatttaggtgaatggcggtcacatatccaggtagctatcaaggcc
atcaatgaaggctccatgtctgaagaggatttcattgaagaggccaaagtgatgatgaaa
ttatctcattcaaagctagtgcaactttatggagtctgtatacagcggaagcccctttac
attgtgacagagttcatggaaaatggctgcctgcttaactatctcagggagaataaagga
aagcttaggaaggaaatgctactgagtgtatgccaggatatatgtgaaggaatggaatat
ctggagaggaatggctatattcatagggatttggcggcaaggaattgtttggtcagttca
acatgcatagtaaaaatttcagactttggaatgacaaggtacgttttggatgatgagtat
gtcagttcttttggagccaagttcccaatcaagtggtcccctcctgaagtttttcttttc
aataagtacagcagtaaatctgatgtctggtcatttggagttttaatgtgggaagttttt
acagaaggaaaaatgccttttgaaaataagtcaaatttgcaagtcgtggaagctatttct
gaaggcttcaggctatatcgccctcacctggcaccaatgtccatatatgaagtcatgtac
agctgctggcatgagaaacctgaaggccgccctacatttgccgagctgctgcgggctgtc
acagagattgcggaaacctggtga
DBGET
integrated database retrieval system