Homo sapiens (human): 3702 Help Entry 3702              CDS       T01001                                  Symbol ITK, EMT, LPFS1, LYK, PSCTK2 Name (RefSeq) IL2 inducible T cell kinase   KO K07363   IL2-inducible T-cell kinase [EC:2.7.10.2] Organism hsa  Homo sapiens (human) Pathway hsa04062   Chemokine signaling pathway hsa04660   T cell receptor signaling pathway hsa04670   Leukocyte transendothelial migration Disease H00107   Other well-defined immunodeficiency syndromes H01970   Lymphoproliferative syndrome Drug target Soquelitinib:  D12762 Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04660 T cell receptor signaling pathway     3702 (ITK)    04670 Leukocyte transendothelial migration     3702 (ITK)    04062 Chemokine signaling pathway     3702 (ITK)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     3702 (ITK) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      3702 (ITK) Protein kinases [BR:hsa01001]  Non-receptor tyrosine kinases   TEC family    3702 (ITK) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 PH SH3_1 BTK SH3_9 SH3_10 SH3_2 PH_8 SH3_3 ABC1 SH3_4 Motif Other DBs NCBI-GeneID:  3702 NCBI-ProteinID:  NP_005537 OMIM:  186973 HGNC:  6171 Ensembl:  ENSG00000113263 UniProt:  Q08881 Structure PDBPDBj LinkDB All DBs Position 5:157180840..157255185 Genome browser AA seq 620 aa AA seqDB search MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE DRPAFSRLLRQLAEIAESGL NT seq 1863 nt NT seq  +upstreamnt  +downstreamnt atgaacaactttatcctcctggaagaacagctcatcaagaaatcccaacaaaagagaaga acttctccctcgaactttaaagtccgcttctttgtgttaaccaaagccagcctggcatac tttgaagatcgtcatgggaagaagcgcacgctgaaggggtccattgagctctcccgaatc aaatgtgttgagattgtgaaaagtgacatcagcatcccatgccactataaatacccgttt caggtggtgcatgacaactacctcctatatgtgtttgctccagatcgtgagagccggcag cgctgggtgctggcccttaaagaagaaacgaggaataataacagtttggtgcctaaatat catcctaatttctggatggatgggaagtggaggtgctgttctcagctggagaagcttgca acaggctgtgcccaatatgatccaaccaagaatgcttcaaagaagcctcttcctcctact cctgaagacaacaggcgaccactttgggaacctgaagaaactgtggtcattgccttatat gactaccaaaccaatgatcctcaggaactcgcactgcggcgcaacgaagagtactgcctg ctggacagttctgagattcactggtggagagtccaggacaggaatgggcatgaaggatat gtaccaagcagttatctggtggaaaaatctccaaataatctggaaacctatgagtggtac aataagagtatcagccgagacaaagctgaaaaacttcttttggacacaggcaaagaagga gccttcatggtaagggattccaggactgcaggaacatacaccgtgtctgttttcaccaag gctgttgtaagtgagaacaatccctgtataaagcattatcacatcaaggaaacaaatgac aatcctaagcgatactatgtggctgaaaagtatgtgttcgattccatccctcttctcatc aactatcaccaacataatggaggaggcctggtgactcgactccggtatccagtttgtttt gggaggcagaaagccccagttacagcagggctgagatacgggaaatgggtgatcgacccc tcagagctcacttttgtgcaagagattggcagtgggcaatttgggttggtgcatctgggc tactggctcaacaaggacaaggtggctatcaaaaccattcgggaaggggctatgtcagaa gaggacttcatagaggaggctgaagtaatgatgaaactctctcatcccaaactggtgcag ctgtatggggtgtgcctggagcaggcccccatctgcctggtgtttgagttcatggagcac ggctgcctgtcagattatctacgcacccagcggggactttttgctgcagagaccctgctg ggcatgtgtctggatgtgtgtgagggcatggcctacctggaagaggcatgtgtcatccac agagacttggctgccagaaattgtttggtgggagaaaaccaagtcatcaaggtgtctgac tttgggatgacaaggttcgttctggatgatcagtacaccagttccacaggcaccaaattc ccggtgaagtgggcatccccagaggttttctctttcagtcgctatagcagcaagtccgat gtgtggtcatttggtgtgctgatgtgggaagttttcagtgaaggcaaaatcccgtatgaa aaccgaagcaactcagaggtggtggaagacatcagtaccggatttcggttgtacaagccc cggctggcctccacacacgtctaccagattatgaatcactgctggaaagagagaccagaa gatcggccagccttctccagactgctgcgtcaactggctgaaattgcagaatcaggactt tag

Homo sapiens (human): 7294 Help Entry 7294              CDS       T01001                                  Symbol TXK, BTKL, PSCTK5, PTK4, RLK, TKL Name (RefSeq) TXK tyrosine kinase   KO K08016   tyrosine-protein kinase TXK [EC:2.7.10.2] Organism hsa  Homo sapiens (human) Pathway hsa04670   Leukocyte transendothelial migration Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     7294 (TXK)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     7294 (TXK) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      7294 (TXK) Protein kinases [BR:hsa01001]  Non-receptor tyrosine kinases   TEC family    7294 (TXK) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_9 SH2_1 ABC1 SH3_10 SH3_2 Motif Other DBs NCBI-GeneID:  7294 NCBI-ProteinID:  NP_003319 OMIM:  600058 HGNC:  12434 Ensembl:  ENSG00000074966 UniProt:  P42681 Structure PDBPDBj LinkDB All DBs Position 4:complement(48066393..48134250) Genome browser AA seq 527 aa AA seqDB search MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW NT seq 1584 nt NT seq  +upstreamnt  +downstreamnt atgatcctttcctcctataacaccatccagtcggttttctgttgctgctgttgctgttca gtgcagaagcgacaaatgagaacacagataagcctgagcacagatgaagagcttccagaa aaatacacccagcgtcgcaggccgtggctcagccaattgtcaaataagaagcaatccaac acgggccgtgtgcagccgtcaaaacgaaagccactgcctcccctcccaccctctgaggtt gctgaagagaagatccaagtcaaggcactttatgattttctgcccagagaaccctgtaat ttagccttaaggagagcagaagaatacctgatactggagaaatacaatcctcactggtgg aaggcaagagaccgtttggggaatgaaggcttaatcccaagcaactatgtgactgaaaac aaaataactaatttagaaatatatgagtggtaccatagaaacattaccagaaatcaggca gaacatctattgagacaagagtctaaagaaggtgcatttattgtcagagattcaagacat ttaggatcctacacaatttccgtatttatgggagctagaagaagtacggaggctgccata aaacattatcagataaaaaagaatgactcaggacagtggtatgtggctgaaagacacgcc tttcaatcaatccctgagttaatctggtatcaccagcacaatgcagccggtctcatgact cgtctccgatatccagttgggctgatgggcagttgtttaccagccacagctgggtttagc tacgaaaagtgggagatagatccatctgagttggcttttataaaggagattggaagcggt cagtttggagtggtccatttaggtgaatggcggtcacatatccaggtagctatcaaggcc atcaatgaaggctccatgtctgaagaggatttcattgaagaggccaaagtgatgatgaaa ttatctcattcaaagctagtgcaactttatggagtctgtatacagcggaagcccctttac attgtgacagagttcatggaaaatggctgcctgcttaactatctcagggagaataaagga aagcttaggaaggaaatgctactgagtgtatgccaggatatatgtgaaggaatggaatat ctggagaggaatggctatattcatagggatttggcggcaaggaattgtttggtcagttca acatgcatagtaaaaatttcagactttggaatgacaaggtacgttttggatgatgagtat gtcagttcttttggagccaagttcccaatcaagtggtcccctcctgaagtttttcttttc aataagtacagcagtaaatctgatgtctggtcatttggagttttaatgtgggaagttttt acagaaggaaaaatgccttttgaaaataagtcaaatttgcaagtcgtggaagctatttct gaaggcttcaggctatatcgccctcacctggcaccaatgtccatatatgaagtcatgtac agctgctggcatgagaaacctgaaggccgccctacatttgccgagctgctgcgggctgtc acagagattgcggaaacctggtga

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