KEGG   Homo sapiens (human): 3714
Entry
3714              CDS       T01001                                 
Symbol
JAG2, HJ2, LGMDR27, SER2
Name
(RefSeq) jagged canonical Notch ligand 2
  KO
K21635  jagged-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04330  Notch signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa05200  Pathways in cancer
hsa05224  Breast cancer
Network
nt06166  Human papillomavirus (HPV)
nt06216  NOTCH signaling (cancer)
nt06270  Breast cancer
nt06465  Prion disease
nt06511  NOTCH signaling
  Element
N00086  Notch signaling pathway
N00087  NOTCH-overexpression to Notch signaling pathway
N01479  Notch ligand ubiquitylation
Disease
H00593  Limb-girdle muscular dystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    3714 (JAG2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    3714 (JAG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3714 (JAG2)
  09162 Cancer: specific types
   05224 Breast cancer
    3714 (JAG2)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    3714 (JAG2)
SSDB
Motif
Pfam: EGF hEGF MNNL EGF_TEN EGF_2 DSL EGF_DL_JAG JAG1-like_EGF2 EGF_CA JAG1 EGF_Teneurin PsbW
Other DBs
NCBI-GeneID: 3714
NCBI-ProteinID: NP_002217
OMIM: 602570
HGNC: 6189
Ensembl: ENSG00000184916
UniProt: Q9Y219
Structure
LinkDB
Position
14:complement(105140995..105168776)
AA seq 1238 aa
MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS
LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC
KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG
GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG
SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC
QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVN
GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC
EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT
AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC
FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT
CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG
WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA
TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD
CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCL
PRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSG
ASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSST
GLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIER
PGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHK
FTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE
NT seq 3717 nt   +upstreamnt  +downstreamnt
atgcgggcgcagggccgggggcgccttccccggcggctgctgctgctgctggcgctctgg
gtgcaggcggcgcggcccatgggctatttcgagctgcagctgagcgcgctgcggaacgtg
aacggggagctgctgagcggcgcctgctgtgacggcgacggccggacaacgcgcgcgggg
ggctgcggccacgacgagtgcgacacgtacgtgcgcgtgtgccttaaggagtaccaggcc
aaggtgacgcccacggggccctgcagctacggccacggcgccacgcccgtgctgggcggc
aactccttctacctgccgccggcgggcgctgcgggggaccgagcgcgggcgcgggcccgg
gccggcggcgaccaggacccgggcctcgtcgtcatccccttccagttcgcctggccgcgc
tcctttaccctcatcgtggaggcctgggactgggacaacgataccaccccgaatgaggag
ctgctgatcgagcgagtgtcgcatgccggcatgatcaacccggaggaccgctggaagagc
ctgcacttcagcggccacgtggcgcacctggagctgcagatccgcgtgcgctgcgacgag
aactactacagcgccacttgcaacaagttctgccggccccgcaacgactttttcggccac
tacacctgcgaccagtacggcaacaaggcctgcatggacggctggatgggcaaggagtgc
aaggaagctgtgtgtaaacaagggtgtaatttgctccacgggggatgcaccgtgcctggg
gagtgcaggtgcagctacggctggcaagggaggttctgcgatgagtgtgtcccctacccc
ggctgcgtgcatggcagttgtgtggagccctggcagtgcaactgtgagaccaactggggc
ggcctgctctgtgacaaagacctgaactactgtggcagccaccacccctgcaccaacgga
ggcacgtgcatcaacgccgagcctgaccagtaccgctgcacctgccctgacggctactcg
ggcaggaactgtgagaaggctgagcacgcctgcacctccaacccgtgtgccaacgggggc
tcttgccatgaggtgccgtccggcttcgaatgccactgcccatcgggctggagcgggccc
acctgtgcccttgacatcgatgagtgtgcttcgaacccgtgtgcggccggtggcacctgt
gtggaccaggtggacggctttgagtgcatctgccccgagcagtgggtgggggccacctgc
cagctggacgccaatgagtgtgaagggaagccatgccttaacgctttttcttgcaaaaac
ctgattggcggctattactgtgattgcatcccgggctggaagggcatcaactgccatatc
aacgtcaacgactgtcgcgggcagtgtcagcatgggggcacctgcaaggacctggtgaac
gggtaccagtgtgtgtgcccacggggcttcggaggccggcattgcgagctggaacgagac
gagtgtgccagcagcccctgccacagcggcggcctctgcgaggacctggccgacggcttc
cactgccactgcccccagggcttctccgggcctctctgtgaggtggatgtcgacctttgt
gagccaagcccctgccggaacggcgctcgctgctataacctggagggtgactattactgc
gcctgccctgatgactttggtggcaagaactgctccgtgccccgcgagccgtgccctggc
ggggcctgcagagtgatcgatggctgcgggtcagacgcggggcctgggatgcctggcaca
gcagcctccggcgtgtgtggcccccatggacgctgcgtcagccagccagggggcaacttt
tcctgcatctgtgacagtggctttactggcacctactgccatgagaacattgacgactgc
ctgggccagccctgccgcaatgggggcacatgcatcgatgaggtggacgccttccgctgc
ttctgccccagcggctgggagggcgagctctgcgacaccaatcccaacgactgccttccc
gatccctgccacagccgcggccgctgctacgacctggtcaatgacttctactgtgcgtgc
gacgacggctggaagggcaagacctgccactcacgcgagttccagtgcgatgcctacacc
tgcagcaacggtggcacctgctacgacagcggcgacaccttccgctgcgcctgccccccc
ggctggaagggcagcacctgcgccgtcgccaagaacagcagctgcctgcccaacccctgt
gtgaatggtggcacctgcgtgggcagcggggcctccttctcctgcatctgccgggacggc
tgggagggtcgtacttgcactcacaataccaacgactgcaaccctctgccttgctacaat
ggtggcatctgtgttgacggcgtcaactggttccgctgcgagtgtgcacctggcttcgcg
gggcctgactgccgcatcaacatcgacgagtgccagtcctcgccctgtgcctacggggcc
acgtgtgtggatgagatcaacgggtatcgctgtagctgcccacccggccgagccggcccc
cggtgccaggaagtgatcgggttcgggagatcctgctggtcccggggcactccgttccca
cacggaagctcctgggtggaagactgcaacagctgccgctgcctggatggccgccgtgac
tgcagcaaggtgtggtgcggatggaagccttgtctgctggccggccagcccgaggccctg
agcgcccagtgcccactggggcaaaggtgcctggagaaggccccaggccagtgtctgcga
ccaccctgtgaggcctggggggagtgcggcgcagaagagccaccgagcaccccctgcctg
ccacgctccggccacctggacaataactgtgcccgcctcaccttgcatttcaaccgtgac
cacgtgccccagggcaccacggtgggcgccatttgctccgggatccgctccctgccagcc
acaagggctgtggcacgggaccgcctgctggtgttgctttgcgaccgggcgtcctcgggg
gccagtgctgtggaggtggccgtgtccttcagccctgccagggacctgcctgacagcagc
ctgatccagggcgcggcccacgccatcgtggccgccatcacccagcgggggaacagctca
ctgctcctggctgtcaccgaggtcaaggtggagacggttgttacgggcggctcttccaca
ggtctgctggtgcctgtgctgtgtggtgccttcagcgtgctgtggctggcgtgcgtggtc
ctgtgcgtgtggtggacacgcaagcgcaggaaagagcgggagaggagccggctgccgcgg
gaggagagcgccaacaaccagtgggccccgctcaaccccatccgcaaccccattgagcgg
ccggggggccacaaggacgtgctctaccagtgcaagaacttcacgccgccgccgcgcagg
gcggacgaggcgctgcccgggccggccggccacgcggccgtcagggaggatgaggaggac
gaggatctgggccgcggtgaggaggactccctggaggcggagaagttcctctcacacaaa
ttcaccaaagatcctggccgctcgccggggaggccggcccactgggcctcaggccccaaa
gtggacaaccgcgcggtcaggagcatcaatgaggcccgctacgccggcaaggagtag

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