KEGG   NETWORK: N00087
Entry
N00087                      Network                                
Name
NOTCH-overexpression to Notch signaling pathway
Definition
(DLL,JAG) -> (NOTCH1*,NOTCH4*) -> (NICD+RBPJ) => (ERBB2,HES1,HES5,HEY,FLT4)
  Expanded
(28514,10683,54567,182,3714) -> (4851v1,4855v1) -> (C22528+(3516,11317)) => (2064,3280,388585,23462,23493,26508,2324)
Class
nt06270 Breast cancer
nt06216 NOTCH signaling (cancer)
Type
Variant
Pathway
hsa05224  Breast cancer
Disease
H00031  Breast cancer
Gene
28514  DLL1; delta like canonical Notch ligand 1
10683  DLL3; delta like canonical Notch ligand 3
54567  DLL4; delta like canonical Notch ligand 4
182  JAG1; jagged 1
3714  JAG2; jagged 2
4851  NOTCH1; notch 1
4855  NOTCH4; notch 4
3516  RBPJ; recombination signal binding protein for immunoglobulin kappa J region
11317  RBPJL; recombination signal binding protein for immunoglobulin kappa J region like
2064  ERBB2; erb-b2 receptor tyrosine kinase 2
3280  HES1; hes family bHLH transcription factor 1
388585  HES5; hes family bHLH transcription factor 5
23462  HEY1; hes related family bHLH transcription factor with YRPW motif 1
23493  HEY2; hes related family bHLH transcription factor with YRPW motif 2
26508  HEYL; hes related family bHLH transcription factor with YRPW motif-like
2324  FLT4; fms related tyrosine kinase 4
Variant
4851v1 (NOTCH1*)  NOTCH1 overexpression
4855v1 (NOTCH4*)  NOTCH4 overexpression
Metabolite
C22528  Notch intracellular domain
Reference
PMID:23196196
  Authors
Karamboulas C, Ailles L
  Title
Developmental signaling pathways in cancer stem cells of solid tumors.
  Journal
Biochim Biophys Acta 1830:2481-95 (2013)
DOI:10.1016/j.bbagen.2012.11.008
Reference
PMID:26040571
  Authors
Jamdade VS, Sethi N, Mundhe NA, Kumar P, Lahkar M, Sinha N
  Title
Therapeutic targets of triple-negative breast cancer: a review.
  Journal
Br J Pharmacol 172:4228-37 (2015)
DOI:10.1111/bph.13211
Reference
PMID:26968398
  Authors
Rangel MC, Bertolette D, Castro NP, Klauzinska M, Cuttitta F, Salomon DS
  Title
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
  Journal
Breast Cancer Res Treat 156:211-26 (2016)
DOI:10.1007/s10549-016-3746-7
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