Homo sapiens (human): 3745
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Entry
3745 CDS
T01001
Symbol
KCNB1, DEE26, DRK1, Kv2.1
Name
(RefSeq) potassium voltage-gated channel subfamily B member 1
KO
K04885
potassium voltage-gated channel Shab-related subfamily B member 1
Organism
hsa
Homo sapiens (human)
Disease
H00606
Early infantile epileptic encephalopathy
Drug target
Amifampridine:
D10228
D10689
<JP/US>
Fampridine:
D04127
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
3745 (KCNB1)
Ion channels [BR:
hsa04040
]
Voltage-gated cation channels
Potassium channel, voltage-gated (Kv)
3745 (KCNB1)
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Gene cluster
GFIT
Motif
Pfam:
Kv2channel
Ion_trans
BTB_2
Ion_trans_2
DUF4790
DUF5843
Motif
Other DBs
NCBI-GeneID:
3745
NCBI-ProteinID:
NP_004966
OMIM:
600397
HGNC:
6231
Ensembl:
ENSG00000158445
UniProt:
Q14721
Structure
PDB
PDBj
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All DBs
Position
20:complement(49363877..49483362)
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AA seq
858 aa
AA seq
DB search
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL
RDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELD
YWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
KPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWF
TMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFR
IMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK
FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY
KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQD
NHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQ
SQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPE
ATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSS
MKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLS
PESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPG
STSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPD
VRVLPGGGAHGSTRDQSI
NT seq
2577 nt
NT seq
+upstream
nt +downstream
nt
atgccggcgggcatgacgaagcatggctcccgctccaccagctcgctgccgcccgagccc
atggagatcgtgcgcagcaaggcgtgctctcggcgggtccgcctcaacgtcggggggctg
gcgcacgaggtactctggcgtaccctggaccgcctgccccgcacgcggctgggcaagctc
cgcgactgcaacacgcacgactcgctgctcgaggtgtgcgatgactacagcctcgacgac
aacgagtacttctttgaccgccacccgggcgccttcacctccatcctcaacttctaccgc
actgggcgactgcacatgatggaggagatgtgcgcgctcagcttcagccaagagctcgac
tactggggcatcgacgagatctacctggagtcctgctgccaggcccgctaccaccagaag
aaagagcagatgaacgaggagctcaagcgtgaggccgagaccctacgggagcgggaaggc
gaggagttcgataacacgtgctgcgcagagaagaggaaaaaactctgggacctactggag
aagcccaattcctctgtggctgccaagatccttgccataatttccatcatgttcatcgtc
ctctccaccattgccctgtccctcaacacgctgcctgagctacagagcctcgatgagttc
ggccagtccacagacaacccccagctggcccacgtggaggccgtgtgcatcgcatggttc
accatggagtacctgctgaggttcctctcctcgcccaagaagtggaagttcttcaagggc
ccactcaatgccattgacttgttggccattctgccatactatgtcaccattttcctcacc
gaatccaacaagagcgtgctgcaattccagaatgtccgccgcgtggtccagatcttccgc
atcatgcgaattctccgcatccttaagcttgcacgccactccactggcctccagtctctg
ggcttcactttgcggaggagctacaatgagttgggcttgctcatcctcttccttgccatg
ggcattatgatcttctccagccttgtcttctttgctgagaaggatgaggacgacaccaag
ttcaaaagcatcccagcctctttctggtgggccaccatcaccatgactactgttgggtat
ggagacatctaccccaagactctcctggggaaaattgttgggggactctgctgcattgca
ggagtcctggtgattgctcttcccatccccatcatcgtcaataacttctctgagttctat
aaggagcagaagagacaggagaaagcaatcaaacggcgagaggctctggagagagccaag
aggaatggcagcatcgtatccatgaacatgaaggatgcttttgcccggagcattgagatg
atggacattgtggttgagaaaaatggggagaatatgggtaagaaagacaaagtacaagat
aaccacttgtctcctaacaaatggaaatggacaaagaggacactgtctgaaaccagctca
agtaagtcctttgaaaccaaggaacagggatcccctgaaaaagccagatcgtcttctagt
cctcagcacctgaacgttcagcagttggaagacatgtacaataagatggccaagacccaa
tcccaacccatcctcaataccaaggagtcagcagcacagagcaaaccaaaggaagaactt
gaaatggagagtatccccagccccgtagcccctctgcccactcgcacagaaggggtcatt
gacatgcgaagtatgtcaagcattgatagtttcattagctgtgccacagacttccctgag
gccaccagattctcccacagccctttgacatcactccccagcaagactgggggcagcaca
gccccagaagtgggctggcggggagctctgggtgccagtggtggtaggtttgtggaggcc
aaccccagccctgatgccagccagcactctagtttcttcatcgagagccccaagagttcc
atgaaaactaacaaccctttgaagctccgagcacttaaagtcaacttcatggagggtgac
cccagtccactcctccccgttctagggatgtaccatgaccctctcaggaaccgggggagt
gctgcggctgctgtcgctggactggagtgtgccacgcttttggacaaggctgtgctgagc
ccagagtcctccatctacaccacagcaagtgctaagacacccccccggtctcctgagaaa
cacacagcaatagcgttcaactttgaggcgggtgtccaccagtacattgacgcagacaca
gatgatgagggacagctgctctacagtgtggactccagcccccccaaaagcctccctggg
agcaccagtccgaagttcagcacggggacaagatcggagaaaaaccactttgaaagctcc
cctttacccacctcccctaagttcttaaggcagaactgtatttactccacagaagcattg
actggaaaaggccccagtggtcaggaaaagtgcaaacttgagaaccacatctcccctgac
gtccgtgtgttgccagggggaggagcccatggaagcacacgagatcagagcatctga
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