KEGG   Homo sapiens (human): 4040
Entry
4040              CDS       T01001                                 
Symbol
LRP6, ADCAD2, STHAG7
Name
(RefSeq) LDL receptor related protein 6
  KO
K03068  low density lipoprotein receptor-related protein 5/6
Organism
hsa  Homo sapiens (human)
Pathway
hsa04150  mTOR signaling pathway
hsa04310  Wnt signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05200  Pathways in cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06115  WNT signaling (viruses and bacteria)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06215  WNT signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
  Element
N00056  Wnt signaling pathway
N00059  FZD7-overexpression to Wnt signaling pathway
N00060  LRP6-overexpression to Wnt signaling pathway
Disease
H00031  Breast cancer
H00625  Tooth agenesis
H01742  Coronary artery disease
H02505  Atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    4040 (LRP6)
   04150 mTOR signaling pathway
    4040 (LRP6)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    4040 (LRP6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4040 (LRP6)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    4040 (LRP6)
   05226 Gastric cancer
    4040 (LRP6)
   05224 Breast cancer
    4040 (LRP6)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4040 (LRP6)
   05022 Pathways of neurodegeneration - multiple diseases
    4040 (LRP6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4040 (LRP6)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    4040 (LRP6)
SSDB
Motif
Pfam: Ldl_recept_b FXa_inhibition Ldl_recept_a DUF5050 SGL cEGF
Other DBs
NCBI-GeneID: 4040
NCBI-ProteinID: NP_002327
OMIM: 603507
HGNC: 6698
Ensembl: ENSG00000070018
Pharos: O75581(Tbio)
UniProt: O75581
Structure
LinkDB
Position
12:complement(12116025..12267044)
AA seq 1613 aa
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVF
SHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE
VSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWT
DWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMS
PVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT
DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSD
RVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTL
LGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCS
HLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTG
VKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLY
WADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDG
SERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQ
YQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHC
SHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILP
IHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLS
IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS
PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE
DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ
EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGE
IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGV
IVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMS
RGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTM
EFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDL
NYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
NT seq 4842 nt   +upstreamnt  +downstreamnt
atgggggccgtcctgaggagcctcctggcctgcagcttctgtgtgctcctgagagcggcc
cctttgttgctttatgcaaacagacgggacttgcgattggttgatgctacaaatggcaaa
gagaatgctacgattgtagttggaggcttggaggatgcagctgcggtggactttgtgttt
agtcatggcttgatatactggagtgatgtcagcgaagaagccattaaacgaacagaattt
aacaaaactgagagtgtgcagaatgttgttgtttctggattattgtcccccgatgggctg
gcatgtgattggcttggagaaaaattgtactggacagattctgaaactaatcggattgaa
gtttctaatttagatggatctttacgaaaagttttattttggcaagagttggatcaaccc
agagctattgccttagatccttcaagtgggttcatgtactggacagactggggagaagtg
ccaaagatagaacgtgctggaatggatggttcaagtcgcttcattataataaacagtgaa
atttactggccaaatggactgactttggattatgaagaacaaaagctttattgggcagat
gcaaaacttaatttcatccacaaatcaaatctggatggaacaaatcggcaggcagtggtt
aaaggttcccttccacatccttttgccttgacgttatttgaggacatattgtactggact
gactggagcacacactccattttggcttgcaacaagtatactggtgagggtctgcgtgaa
atccattctgacatcttctctcccatggatatacatgccttcagccaacagaggcagcca
aatgccacaaatccatgtggaattgacaatgggggttgttcccatttgtgtttgatgtct
ccagtcaagcctttttatcagtgtgcttgccccactggggtcaaactcctggagaatgga
aaaacctgcaaagatggtgccacagaattattgcttttagctcgaaggacagacttgaga
cgcatttctttggatacaccagattttacagacattgttctgcagttagaagacatccgt
catgccattgccatagattacgatcctgtggaaggctacatctactggactgatgatgaa
gtgagggccatacgccgttcatttatagatggatctggcagtcagtttgtggtcactgct
caaattgcccatcctgatggtattgctgtggactgggttgcacgaaatctttattggaca
gacactggcactgatcgaatagaagtgacaaggctcaatgggaccatgaggaagatcttg
atttcagaggacttagaggaaccccgggctattgtgttagatcccatggttgggtacatg
tattggactgactggggagaaattccgaaaattgagcgagcagctctggatggttctgac
cgtgtagtattggttaacacttctcttggttggccaaatggtttagccttggattatgat
gaaggcaaaatatactggggagatgccaaaacagacaagattgaggttatgaatactgat
ggcactgggagacgagtactagtggaagacaaaattcctcacatatttggatttactttg
ttgggtgactatgtttactggactgactggcagaggcgtagcattgaaagagttcataaa
cgaagtgcagagagggaagtgatcatagatcagctgcctgacctcatgggcctaaaggct
acaaatgttcatcgagtgattggttccaacccctgtgctgaggaaaacgggggatgtagc
catctctgcctctatagacctcagggccttcgctgtgcttgccctattggctttgaactc
atcagtgacatgaagacctgcattgtcccagaggctttccttttgttttcacggagagca
gatatcagacgaatttctctggaaacaaacaataataatgtggctattccactcactggt
gtcaaagaagcttctgctttggattttgatgtgacagacaaccgaatttattggactgat
atatcactcaagaccatcagcagagcctttatgaatggcagtgcactggaacatgtggta
gaattcggcttagattatccagaaggcatggcagtagactggcttgggaagaacttgtac
tgggcagacacaggaacgaatcgaattgaggtgtcaaagttggatgggcagcaccgacaa
gttttggtgtggaaagacctagatagtcccagagctctcgcgttggaccctgccgaagga
tttatgtattggactgaatggggtggaaaacctaagatagacagagctgcaatggatgga
agtgaacgtactaccttagttccaaatgtggggcgggcaaacggcctaactattgattat
gctaaaaggaggctttattggacagacctggacaccaacttaatagaatcttcaaatatg
cttgggctcaaccgtgaagttatagcagatgacttgcctcatccttttggcttaactcag
taccaagattatatctactggacggactggagccgacgcagcattgagcgtgccaacaaa
accagtggccaaaaccgcaccatcattcagggccatttggattatgtgatggacatcctc
gtctttcactcatctcgacagtcagggtggaatgaatgtgcttccagcaatgggcactgc
tcccacctctgcttggctgtgccagttgggggttttgtttgtggatgccctgcccactac
tctcttaatgctgacaacaggacttgtagtgctcctacgactttcctgctcttcagtcaa
aagagtgccatcaaccgcatggtgattgatgaacaacagagccccgacatcatccttccc
atccacagccttcggaatgtccgggccattgactatgacccactggacaagcaactctat
tggattgactcacgacaaaacatgatccgaaaggcacaagaagatggcagccagggcttt
actgtggttgtgagctcagttccgagtcagaacctggaaatacaaccctatgacctcagc
attgatatttacagccgctacatctactggacttgtgaggctaccaatgtcattaatgtg
acaagattagatgggagatcagttggagtggtgctgaaaggcgagcaggacagacctcga
gccgttgtggtaaacccagagaaagggtatatgtattttaccaatcttcaggaaaggtct
cctaaaattgaacgggctgctttggatgggacagaacgggaggtcctctttttcagtggc
ttaagtaaaccaattgctttagcccttgatagcaggctgggcaagctcttttgggctgat
tcagatctccggcgaattgaaagcagtgatctctcaggtgctaaccggatagtattagaa
gactccaatatcttgcagcctgtgggacttactgtgtttgaaaactggctctattggatt
gataaacagcagcaaatgattgaaaaaattgacatgacaggtcgagagggtagaaccaaa
gtccaagctcgaattgcccagcttagtgacattcatgcagtaaaggagctgaaccttcaa
gaatacagacagcacccttgtgctcaggataatggtggctgttcacatatttgtcttgta
aagggggatggtactacaaggtgttcttgccccatgcacctggttctacttcaagatgag
ctatcatgtggagaacctccaacatgttctcctcagcagtttacttgtttcacgggggaa
attgactgtatccctgtggcttggcggtgcgatgggtttactgaatgtgaagaccacagt
gatgaactcaattgtcctgtatgctcagagtcccagttccagtgtgccagtgggcagtgt
attgatggtgccctccgatgcaatggagatgcaaactgccaggacaaatcagatgagaag
aactgtgaagtgctttgtttaattgatcagttccgctgtgccaatggtcagtgcattgga
aagcacaagaagtgtgatcataatgtggattgcagtgacaagtcagatgaactggattgt
tatccgactgaagaaccagcaccacaggccaccaatacagttggttctgttattggcgta
attgtcaccatttttgtgtctggaactgtatactttatctgccagaggatgttgtgtcca
cgtatgaagggagatggggaaactatgactaatgactatgtagttcatggaccagcttct
gtgcctcttggttatgtgccacacccaagttctttgtcaggatctcttccaggaatgtct
cgaggtaaatcaatgatcagctccctcagtatcatggggggaagcagtggacccccctat
gaccgagcccatgttacaggagcatcatcaagtagttcttcaagcaccaaaggcacttac
ttccctgcaattttgaaccctccaccatccccagccacagagcgatcacattacactatg
gaatttggatattcttcaaacagtccttccactcataggtcatacagctacaggccatat
agctaccggcactttgcaccccccaccacaccctgcagcacagatgtttgtgacagtgac
tatgctcctagtcggagaatgacctcagtggcaacagccaagggctataccagtgacttg
aactatgattcagaacctgtgcccccacctcccacaccccgaagccaatacttgtcagca
gaggagaactatgaaagctgcccaccttctccatacacagagaggagctattctcatcac
ctctacccaccgccaccctctccctgtacagactcctcctga

KEGG   Homo sapiens (human): 4041
Entry
4041              CDS       T01001                                 
Symbol
LRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP-7, LRP7, OPPG, OPS, OPTA1, PCLD4, VBCH2
Name
(RefSeq) LDL receptor related protein 5
  KO
K03068  low density lipoprotein receptor-related protein 5/6
Organism
hsa  Homo sapiens (human)
Pathway
hsa04150  mTOR signaling pathway
hsa04310  Wnt signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05200  Pathways in cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06115  WNT signaling (viruses and bacteria)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06215  WNT signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
  Element
N00056  Wnt signaling pathway
N00059  FZD7-overexpression to Wnt signaling pathway
Disease
H00436  Osteopetrosis
H00450  Worth type autosomal dominant osteosclerosis
H00451  Osteoporosis-pseudoglioma syndrome
H00545  Polycystic liver disease
H00589  Familial exudative vitreoretinopathy
H01593  Osteoporosis
H01774  Hyperostosis corticalis generalisata
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    4041 (LRP5)
   04150 mTOR signaling pathway
    4041 (LRP5)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    4041 (LRP5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4041 (LRP5)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    4041 (LRP5)
   05226 Gastric cancer
    4041 (LRP5)
   05224 Breast cancer
    4041 (LRP5)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4041 (LRP5)
   05022 Pathways of neurodegeneration - multiple diseases
    4041 (LRP5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4041 (LRP5)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    4041 (LRP5)
SSDB
Motif
Pfam: Ldl_recept_b FXa_inhibition Ldl_recept_a DUF5050 SGL Insulin_TMD Gp3-like
Other DBs
NCBI-GeneID: 4041
NCBI-ProteinID: NP_002326
OMIM: 603506
HGNC: 6697
Ensembl: ENSG00000162337
Pharos: O75197(Tbio)
UniProt: O75197
LinkDB
Position
11:68298412..68449275
AA seq 1615 aa
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVS
GLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGK
KLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHP
FALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE
EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDG
IAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGE
NPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL
LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVV
GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL
ETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP
EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEW
GGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVV
IADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ
DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMI
PDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQ
NPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY
LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCD
LSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTG
IHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS
PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGE
ADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDS
PAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAP
GGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNP
PPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKAS
KYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS
NT seq 4848 nt   +upstreamnt  +downstreamnt
atggaggcagcgccgcccgggccgccgtggccgctgctgctgctgctgctgctgctgctg
gcgctgtgcggctgcccggcccccgccgcggcctcgccgctcctgctatttgccaaccgc
cgggacgtacggctggtggacgccggcggagtcaagctggagtccaccatcgtggtcagc
ggcctggaggatgcggccgcagtggacttccagttttccaagggagccgtgtactggaca
gacgtgagcgaggaggccatcaagcagacctacctgaaccagacgggggccgccgtgcag
aacgtggtcatctccggcctggtctctcccgacggcctcgcctgcgactgggtgggcaag
aagctgtactggacggactcagagaccaaccgcatcgaggtggccaacctcaatggcaca
tcccggaaggtgctcttctggcaggaccttgaccagccgagggccatcgccttggacccc
gctcacgggtacatgtactggacagactggggtgagacgccccggattgagcgggcaggg
atggatggcagcacccggaagatcattgtggactcggacatttactggcccaatggactg
accatcgacctggaggagcagaagctctactgggctgacgccaagctcagcttcatccac
cgtgccaacctggacggctcgttccggcagaaggtggtggagggcagcctgacgcacccc
ttcgccctgacgctctccggggacactctgtactggacagactggcagacccgctccatc
catgcctgcaacaagcgcactggggggaagaggaaggagatcctgagtgccctctactca
cccatggacatccaggtgctgagccaggagcggcagcctttcttccacactcgctgtgag
gaggacaatggcggctgctcccacctgtgcctgctgtccccaagcgagcctttctacaca
tgcgcctgccccacgggtgtgcagctgcaggacaacggcaggacgtgtaaggcaggagcc
gaggaggtgctgctgctggcccggcggacggacctacggaggatctcgctggacacgccg
gacttcaccgacatcgtgctgcaggtggacgacatccggcacgccattgccatcgactac
gacccgctagagggctatgtctactggacagatgacgaggtgcgggccatccgcagggcg
tacctggacgggtctggggcgcagacgctggtcaacaccgagatcaacgaccccgatggc
atcgcggtcgactgggtggcccgaaacctctactggaccgacacgggcacggaccgcatc
gaggtgacgcgcctcaacggcacctcccgcaagatcctggtgtcggaggacctggacgag
ccccgagccatcgcactgcaccccgtgatgggcctcatgtactggacagactggggagag
aaccctaaaatcgagtgtgccaacttggatgggcaggagcggcgtgtgctggtcaatgcc
tccctcgggtggcccaacggcctggccctggacctgcaggaggggaagctctactgggga
gacgccaagacagacaagatcgaggtgatcaatgttgatgggacgaagaggcggaccctc
ctggaggacaagctcccgcacatttttgggttcacgctgctgggggacttcatctactgg
actgactggcagcgccgcagcatcgagcgggtgcacaaggtcaaggccagccgggacgtc
atcattgaccagctgcccgacctgatggggctcaaagctgtgaatgtggccaaggtcgtc
ggaaccaacccgtgtgcggacaggaacggggggtgcagccacctgtgcttcttcacaccc
cacgcaacccggtgtggctgccccatcggcctggagctgctgagtgacatgaagacctgc
atcgtgcctgaggccttcttggtcttcaccagcagagccgccatccacaggatctccctc
gagaccaataacaacgacgtggccatcccgctcacgggcgtcaaggaggcctcagccctg
gactttgatgtgtccaacaaccacatctactggacagacgtcagcctgaagaccatcagc
cgcgccttcatgaacgggagctcggtggagcacgtggtggagtttggccttgactacccc
gagggcatggccgttgactggatgggcaagaacctctactgggccgacactgggaccaac
agaatcgaagtggcgcggctggacgggcagttccggcaagtcctcgtgtggagggacttg
gacaacccgaggtcgctggccctggatcccaccaagggctacatctactggaccgagtgg
ggcggcaagccgaggatcgtgcgggccttcatggacgggaccaactgcatgacgctggtg
gacaaggtgggccgggccaacgacctcaccattgactacgctgaccagcgcctctactgg
accgacctggacaccaacatgatcgagtcgtccaacatgctgggtcaggagcgggtcgtg
attgccgacgatctcccgcacccgttcggtctgacgcagtacagcgattatatctactgg
acagactggaatctgcacagcattgagcgggccgacaagactagcggccggaaccgcacc
ctcatccagggccacctggacttcgtgatggacatcctggtgttccactcctcccgccag
gatggcctcaatgactgtatgcacaacaacgggcagtgtgggcagctgtgccttgccatc
cccggcggccaccgctgcggctgcgcctcacactacaccctggaccccagcagccgcaac
tgcagcccgcccaccaccttcttgctgttcagccagaaatctgccatcagtcggatgatc
ccggacgaccagcacagcccggatctcatcctgcccctgcatggactgaggaacgtcaaa
gccatcgactatgacccactggacaagttcatctactgggtggatgggcgccagaacatc
aagcgagccaaggacgacgggacccagccctttgttttgacctctctgagccaaggccaa
aacccagacaggcagccccacgacctcagcatcgacatctacagccggacactgttctgg
acgtgcgaggccaccaataccatcaacgtccacaggctgagcggggaagccatgggggtg
gtgctgcgtggggaccgcgacaagcccagggccatcgtcgtcaacgcggagcgagggtac
ctgtacttcaccaacatgcaggaccgggcagccaagatcgaacgcgcagccctggacggc
accgagcgcgaggtcctcttcaccaccggcctcatccgccctgtggccctggtggtggac
aacacactgggcaagctgttctgggtggacgcggacctgaagcgcattgagagctgtgac
ctgtcaggggccaaccgcctgaccctggaggacgccaacatcgtgcagcctctgggcctg
accatccttggcaagcatctctactggatcgaccgccagcagcagatgatcgagcgtgtg
gagaagaccaccggggacaagcggactcgcatccagggccgtgtcgcccacctcactggc
atccatgcagtggaggaagtcagcctggaggagttctcagcccacccatgtgcccgtgac
aatggtggctgctcccacatctgtattgccaagggtgatgggacaccacggtgctcatgc
ccagtccacctcgtgctcctgcagaacctgctgacctgtggagagccgcccacctgctcc
ccggaccagtttgcatgtgccacaggggagatcgactgtatccccggggcctggcgctgt
gacggctttcccgagtgcgatgaccagagcgacgaggagggctgccccgtgtgctccgcc
gcccagttcccctgcgcgcggggtcagtgtgtggacctgcgcctgcgctgcgacggcgag
gcagactgtcaggaccgctcagacgaggcggactgtgacgccatctgcctgcccaaccag
ttccggtgtgcgagcggccagtgtgtcctcatcaaacagcagtgcgactccttccccgac
tgtatcgacggctccgacgagctcatgtgtgaaatcaccaagccgccctcagacgacagc
ccggcccacagcagtgccatcgggcccgtcattggcatcatcctctctctcttcgtcatg
ggtggtgtctattttgtgtgccagcgcgtggtgtgccagcgctatgcgggggccaacggg
cccttcccgcacgagtatgtcagcgggaccccgcacgtgcccctcaatttcatagccccg
ggcggttcccagcatggccccttcacaggcatcgcatgcggaaagtccatgatgagctcc
gtgagcctgatggggggccggggcggggtgcccctctacgaccggaaccacgtcacaggg
gcctcgtccagcagctcgtccagcacgaaggccacgctgtacccgccgatcctgaacccg
ccgccctccccggccacggacccctccctgtacaacatggacatgttctactcttcaaac
attccggccactgcgagaccgtacaggccctacatcattcgaggaatggcgcccccgacg
acgccctgcagcaccgacgtgtgtgacagcgactacagcgccagccgctggaaggccagc
aagtactacctggatttgaactcggactcagacccctatccacccccacccacgccccac
agccagtacctgtcggcggaggacagctgcccgccctcgcccgccaccgagaggagctac
ttccatctcttcccgccccctccgtccccctgcacggactcatcctga

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