Homo sapiens (human): 412
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Entry
412 CDS
T01001
Symbol
STS, ARSC, ARSC1, ASC, ES, SSDD, XLI
Name
(RefSeq) steroid sulfatase
KO
K01131
steryl-sulfatase [EC:
3.1.6.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00140
Steroid hormone biosynthesis
hsa01100
Metabolic pathways
Disease
H00134
X-linked ichthyosis
Drug target
Irosustat:
D09915
Brite
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.6 Sulfuric-ester hydrolases
3.1.6.2 steryl-sulfatase
412 (STS)
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Gene cluster
GFIT
Motif
Pfam:
Sulfatase
Sulfatase_C
SGSH_C
Phosphodiest
NAD_binding_8
Motif
Other DBs
NCBI-GeneID:
412
NCBI-ProteinID:
NP_000342
OMIM:
300747
HGNC:
11425
Ensembl:
ENSG00000101846
UniProt:
P08842
A0A590UJL0
Structure
PDB
PDBj
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All DBs
Position
X:7147290..7354641
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AA seq
578 aa
AA seq
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MKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKL
TQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQ
GYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRL
VFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMM
RNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQH
GVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYK
GGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRD
LMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATH
VCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVP
DQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
NT seq
1737 nt
NT seq
+upstream
nt +downstream
nt
atgaagatccctttcctcctactgttctttctgtgggaagccgagagccacgcagcatca
aggccgaacatcatcctggtgatggctgacgacctcggcattggagatcctgggtgctat
gggaacaaaactatcaggactcccaatatcgaccggttggccagtgggggagtgaaactc
actcagcacctggcagcatcaccgctgtgcacaccaagcagggcagccttcatgactggc
cggtaccctgtccgatcaggaatggcatcttggtcccgcactggagttttcctcttcaca
gcctcttcgggaggacttcccaccgatgagattacctttgctaagcttctgaaggatcaa
ggttattcaacagcactgatagggaaatggcaccttgggatgagctgtcacagcaagact
gacttctgtcaccaccctttacatcacggcttcaattatttctatgggatctctttgacc
aatctgagagactgcaagcccggagagggcagtgtcttcaccacgggcttcaagaggctg
gtcttcctccccctgcagatcgtcggggtcaccctccttacccttgctgcactcaattgt
ctggggctactccacgtgcctctaggcgtttttttcagccttctcttcctagcagcccta
atcctgacccttttcttgggcttccttcattacttccggcccctgaactgcttcatgatg
aggaactacgagatcattcagcagcccatgtcctatgacaatctcacccagaggctaacg
gtggaggcggcccagttcatacagcggaacactgagactccgttcctgcttgtcttgtcc
tacctccacgtgcacacagccctgttctccagcaaagactttgctggcaaaagtcaacac
ggagtctacggggatgctgttgaggaaatggactggagtgtggggcagatcttgaacctt
ctggatgagctgagattggctaatgataccctcatctacttcacatcggaccagggagca
catgtagaagaagtgtcttccaaaggagaaattcatggcggaagtaatgggatctataaa
ggaggaaaagcaaacaactgggaaggaggtatccgggttccaggcatccttcgttggccc
agggtgatacaggctggccagaagattgatgagcccactagcaacatggacatatttcct
acagtagccaagctggctggagctcccttgcctgaggacaggatcattgatggacgtgat
ctgatgcccctgcttgaaggaaaaagccaacgctccgatcatgagtttctcttccattac
tgcaacgcctacttaaatgctgtgcgctggcaccctcagaacagcacatccatctggaag
gcctttttcttcacccccaacttcaaccccgtgggttccaacggatgctttgccacacac
gtgtgcttctgtttcgggagttatgtcacccatcacgacccacctttactctttgatatt
tccaaagatcccagagagagaaacccactaactccagcatccgagccccggttttatgaa
atcctcaaagtcatgcaggaagctgcggacagacacacccagaccctgccagaggtgccc
gatcagttttcatggaacaactttctttggaagccctggcttcagctgtgctgtccttcc
accggcctgtcttgccagtgtgatagagaaaaacaggataagagactgagccgctag
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