Homo sapiens (human): 427
Help
Entry
427 CDS
T01001
Symbol
ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME
Name
(RefSeq) N-acylsphingosine amidohydrolase 1
KO
K12348
acid ceramidase [EC:
3.5.1.23
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00600
Sphingolipid metabolism
hsa01100
Metabolic pathways
hsa04071
Sphingolipid signaling pathway
hsa04142
Lysosome
Module
hsa_M00099
Sphingosine biosynthesis
Network
nt06014
Sphingolipid degradation
Element
N00649
Hydrolysis of sphingomyelin
Disease
H00138
Farber lipogranulomatosis
H00423
Sphingolipidosis
H00424
Defects in the degradation of sphingomyelin
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00600 Sphingolipid metabolism
427 (ASAH1)
09130 Environmental Information Processing
09132 Signal transduction
04071 Sphingolipid signaling pathway
427 (ASAH1)
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
427 (ASAH1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
427 (ASAH1)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
427 (ASAH1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.23 ceramidase
427 (ASAH1)
Peptidases and inhibitors [BR:
hsa01002
]
Cysteine peptidases
Family C89
427 (ASAH1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
427 (ASAH1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
CBAH
NAAA-beta
AAT
DUF502
HP_OMP
Motif
Other DBs
NCBI-GeneID:
427
NCBI-ProteinID:
NP_808592
OMIM:
613468
HGNC:
735
Ensembl:
ENSG00000104763
UniProt:
Q13510
Q53H01
A8K0B6
Structure
PDB
PDBj
LinkDB
All DBs
Position
8:complement(18055992..18084961)
Genome browser
AA seq
395 aa
AA seq
DB search
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
NT seq
1188 nt
NT seq
+upstream
nt +downstream
nt
atgccgggccggagttgcgtcgccttagtcctcctggctgccgccgtcagctgtgccgtc
gcgcagcacgcgccgccgtggacagaggactgcagaaaatcaacctatcctccttcagga
ccaacgtacagaggtgcagttccatggtacaccataaatcttgacttaccaccctacaaa
agatggcatgaattgatgcttgacaaggcaccagtgctaaaggttatagtgaattctctg
aagaatatgataaatacattcgtgccaagtggaaaaattatgcaggtggtggatgaaaaa
ttgcctggcctacttggcaactttcctggcccttttgaagaggaaatgaagggtattgcc
gctgttactgatatacctttaggagagattatttcattcaatattttttatgaattattt
accatttgtacttcaatagtagcagaagacaaaaaaggtcatctaatacatgggagaaac
atggattttggagtatttcttgggtggaacataaataatgatacctgggtcataactgag
caactaaaacctttaacagtgaatttggatttccaaagaaacaacaaaactgtcttcaag
gcttcaagctttgctggctatgtgggcatgttaacaggattcaaaccaggactgttcagt
cttacactgaatgaacgtttcagtataaatggtggttatctgggtattctagaatggatt
ctgggaaagaaagatgtcatgtggatagggttcctcactagaacagttctggaaaatagc
acaagttatgaagaagccaagaatttattgaccaagaccaagatattggccccagcctac
tttatcctgggaggcaaccagtctggggaaggttgtgtgattacacgagacagaaaggaa
tcattggatgtatatgaactcgatgctaagcagggtagatggtatgtggtacaaacaaat
tatgaccgttggaaacatcccttcttccttgatgatcgcagaacgcctgcaaagatgtgt
ctgaaccgcaccagccaagagaatatctcatttgaaaccatgtatgatgtcctgtcaaca
aaacctgtcctcaacaagctgaccgtatacacaaccttgatagatgttaccaaaggtcaa
ttcgaaacttacctgcgggactgccctgacccttgtataggttggtga
Homo sapiens (human): 56624
Help
Entry
56624 CDS
T01001
Symbol
ASAH2, BCDase, HNAC1, LCDase, N-CDase, NCDase
Name
(RefSeq) N-acylsphingosine amidohydrolase 2
KO
K12349
neutral ceramidase [EC:
3.5.1.23
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00600
Sphingolipid metabolism
hsa01100
Metabolic pathways
hsa04071
Sphingolipid signaling pathway
Module
hsa_M00099
Sphingosine biosynthesis
Network
nt06014
Sphingolipid degradation
Element
N00649
Hydrolysis of sphingomyelin
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00600 Sphingolipid metabolism
56624 (ASAH2)
09130 Environmental Information Processing
09132 Signal transduction
04071 Sphingolipid signaling pathway
56624 (ASAH2)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.23 ceramidase
56624 (ASAH2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ceramidase_alk
Ceramidse_alk_C
Pga1
Motif
Other DBs
NCBI-GeneID:
56624
NCBI-ProteinID:
NP_063946
OMIM:
611202
HGNC:
18860
Ensembl:
ENSG00000188611
UniProt:
Q9NR71
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:complement(50184861..50251516)
Genome browser
AA seq
780 aa
AA seq
DB search
MAKRTFSNLETFLIFLLVMMSAITVALLSLLFITSGTIENHKDLGGHFFSTTQSPPATQG
STAAQRSTATQHSTATQSSTATQTSPVPLTPESPLFQNFSGYHIGVGRADCTGQVADINL
MGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSIDIGMVSQRLRLEVLNRLQSKYG
SLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSIDIAHTNMKP
GKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLNGDDLGLISWF
AIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVAAFASSNLGDVSPNILGP
RCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRAMYQRAKELYASASQEVT
GPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDGVGGLNFTQGKTEGDPFW
DTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVDVQIITLGSLAITAIPGE
FTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGP
HTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIPSIVDRAPKGRTFGDVLQ
PAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFY
WHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPAVILSFEGTSPAFEVVTI
NT seq
2343 nt
NT seq
+upstream
nt +downstream
nt
atggccaaacgcaccttctctaacttggagacattcctgattttcctccttgtaatgatg
agtgccatcacagtggcccttctcagcctcttgtttatcaccagtgggaccattgaaaac
cacaaagatttaggaggccattttttttcaaccacccaaagccctccagccacccagggc
tccacagctgcccaacgctccacagccacccagcattccacagccacccagagctccaca
gccactcaaacttctccagtgcctttaaccccagagtctcctctatttcagaacttcagt
ggctaccatattggtgttggacgagctgactgcacaggacaagtagcagatatcaatttg
atgggctatggcaaatccggccagaatgcacagggcatcctcaccaggctatacagtcgt
gccttcatcatggcagaacctgatgggtccaatcgaacagtgtttgtcagcatcgacata
ggcatggtatcacaaaggctcaggctggaggtcctgaacagactgcagagtaaatatggc
tccctgtacagaagagataatgtcatcctgagtggcactcacactcattcaggtcctgca
ggatatttccagtataccgtgtttgtaattgccagtgaaggatttagcaatcaaactttt
cagcacatggtcactggtatcttgaagagcattgacatagcacacacaaatatgaaacca
ggcaaaatcttcatcaataaaggaaatgtggatggtgtgcagatcaacagaagtccgtat
tcttaccttcaaaatccgcagtcagagagagcaaggtattcttcaaatacagacaaggaa
atgatagttttgaaaatggtagatttgaatggagatgacttgggccttatcagctggttt
gccatccacccggtcagcatgaacaacagtaaccatcttgtaaacagtgacaatgtgggc
tatgcatcttacctgcttgagcaagagaagaacaaaggatatctacctggacaggggcca
tttgtagcagcctttgcttcatcaaacctaggagatgtgtcccccaacattcttggacca
cgttgcatcaacacaggagagtcctgtgataacgccaatagcacttgtcccattggtggg
cctagcatgtgcattgctaagggacctggacaggatatgtttgacagcacacaaattata
ggacgggccatgtatcagagagcaaaggaactctatgcctctgcctcccaggaggtaaca
ggaccactggcttcagcacaccagtgggtggatatgacagatgtgactgtctggctcaat
tccacacatgcatcaaaaacatgtaaaccagcattgggctacagttttgcagctggcact
attgatggagttggaggcctcaattttacacaggggaaaacagaaggggatccattttgg
gacaccattcgggaccagatcctgggaaagccatctgaagaaattaaagaatgtcataaa
ccaaagcccatccttcttcacaccggagaactatcaaaacctcacccctggcatccagac
attgttgatgttcagattattacccttgggtccttggccataactgccatccccggggag
tttacgaccatgtctggacgaagacttcgagaggcagttcaagcagaatttgcatctcat
gggatgcagaacatgactgttgttatttcaggtctatgcaacgtctatacacattacatt
accacttatgaagaataccaggctcagcgatatgaggcagcatcgacaatttatggaccg
cacacattatctgcttacattcagctcttcagaaaccttgctaaggctattgctacggac
acggtagccaacctgagcagaggtccagaacctccctttttcaaacaattaatagttcca
ttaattcctagtattgtggatagagcaccaaaaggcagaactttcggggatgtcctgcag
ccagcaaaacctgaatacagagtgggggaagttgctgaagttatatttgtaggtgctaac
ccgaagaattcagtacaaaaccagacccatcagaccttcctcactgtggagaaatatgag
gctacttcaacatcgtggcagatagtgtgtaatgatgcctcctgggagactcgtttttat
tggcacaagggactcctgggtctgagtaatgcaacagtggaatggcatattccagacact
gcccagcctggaatctacagaataagatattttggacacaatcggaagcaggacattctg
aagcctgctgtcatactttcatttgaaggcacttccccggcttttgaagttgtaactatt
tag
Homo sapiens (human): 125981
Help
Entry
125981 CDS
T01001
Symbol
ACER1, ALKCDase1, ASAH3
Name
(RefSeq) alkaline ceramidase 1
KO
K01441
alkaline ceramidase [EC:
3.5.1.23
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00600
Sphingolipid metabolism
hsa01100
Metabolic pathways
hsa04071
Sphingolipid signaling pathway
Module
hsa_M00099
Sphingosine biosynthesis
Network
nt06014
Sphingolipid degradation
Element
N00649
Hydrolysis of sphingomyelin
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00600 Sphingolipid metabolism
125981 (ACER1)
09130 Environmental Information Processing
09132 Signal transduction
04071 Sphingolipid signaling pathway
125981 (ACER1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.23 ceramidase
125981 (ACER1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ceramidase
Motif
Other DBs
NCBI-GeneID:
125981
NCBI-ProteinID:
NP_597999
OMIM:
613491
HGNC:
18356
Ensembl:
ENSG00000167769
UniProt:
Q8TDN7
LinkDB
All DBs
Position
19:complement(6306142..6360368)
Genome browser
AA seq
264 aa
AA seq
DB search
MPSIFAYQSSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIY
VVWVLFMIIGLFSMYFHMTLSFLGQLLDEIAILWLLGSGYSIWMPRCYFPSFLGGNRSQF
IRLVFITTVVSTLLSFLRPTVNAYALNSIALHILYIVCQEYRKTSNKELRHLIEVSVVLW
AVALTSWISDRLLCSFWQRIHFFYLHSIWHVLISITFPYGMVTMALVDANYEMPGETLKV
RYWPRDSWPVGLPYVEIRGDDKDC
NT seq
795 nt
NT seq
+upstream
nt +downstream
nt
atgcctagcatcttcgcctatcagagctccgaggtggactggtgtgagagcaacttccag
tactcggagctggtggccgagttctacaacacgttctccaatatccccttcttcatcttc
gggccactgatgatgctcctgatgcacccgtatgcccagaagcgctcccgctacatttac
gttgtctgggtcctcttcatgatcataggcctgttctccatgtatttccacatgacgctc
agcttcctgggccagctgctggacgagatcgccatcctgtggctcctgggcagtggctat
agcatatggatgccccgctgctatttcccctccttccttggggggaacaggtcccagttc
atccgcctggtcttcatcaccactgtggtcagcacccttctgtccttcctgcggcccacg
gtcaacgcctacgccctcaacagcattgccctgcacattctctacatcgtgtgccaggag
tacaggaagaccagcaataaggagcttcggcacctgattgaggtctccgtggttttatgg
gctgttgctctgaccagctggatcagtgaccgtctgctttgcagcttctggcagaggatt
catttcttctatctgcacagcatctggcatgtgctcatcagcatcaccttcccttatggc
atggtcaccatggccttggtggatgccaactatgagatgccaggtgaaaccctcaaagtc
cgctactggcctcgggacagttggcccgtggggctgccctacgtggaaatccggggtgat
gacaaggactgctga
Homo sapiens (human): 340485
Help
Entry
340485 CDS
T01001
Symbol
ACER2, ALKCDase2, ASAH3L
Name
(RefSeq) alkaline ceramidase 2
KO
K01441
alkaline ceramidase [EC:
3.5.1.23
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00600
Sphingolipid metabolism
hsa01100
Metabolic pathways
hsa04071
Sphingolipid signaling pathway
Module
hsa_M00099
Sphingosine biosynthesis
Network
nt06014
Sphingolipid degradation
Element
N00649
Hydrolysis of sphingomyelin
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00600 Sphingolipid metabolism
340485 (ACER2)
09130 Environmental Information Processing
09132 Signal transduction
04071 Sphingolipid signaling pathway
340485 (ACER2)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.23 ceramidase
340485 (ACER2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ceramidase
Motif
Other DBs
NCBI-GeneID:
340485
NCBI-ProteinID:
NP_001010887
OMIM:
613492
HGNC:
23675
Ensembl:
ENSG00000177076
UniProt:
Q5QJU3
B3KVV5
LinkDB
All DBs
Position
9:19409009..19452505
Genome browser
AA seq
275 aa
AA seq
DB search
MGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCF
NSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWVLMCALAMWFPRRYLPKIFRN
DRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRCDNMRVFKLGLF
SGLWWTLALFCWISDRAFCELLSSFNFPYLHCMWHILICLAAYLGCVCFAYFDAASEIPE
QGPVIKFWPNEKWAFIGVPYVSLLCANKKSSVKIT
NT seq
828 nt
NT seq
+upstream
nt +downstream
nt
atgggcgccccgcactggtgggaccagctgcaggctggtagctcggaggtggactggtgc
gaggacaactacaccatcgtgcctgctatcgccgagttctacaacacgatcagcaatgtc
ttatttttcattttaccgcccatctgcatgtgcttgtttcgtcagtatgcaacatgcttc
aacagtggcatctacttaatctggactcttttggttgtagtgggaattggatccgtctac
ttccatgcaacccttagtttcttgggtcagatgcttgatgaacttgcagtcctttgggtt
ctgatgtgtgctttggccatgtggttccccagaaggtatctaccaaagatctttcggaat
gaccggggtaggttcaaggtggtggtcagtgtcctgtctgcggttacgacgtgcctggca
tttgtcaagcctgccatcaacaacatctctctgatgaccctgggagttccttgcactgca
ctgctcatcgcagagctaaagaggtgtgacaacatgcgtgtgtttaagctgggcctcttc
tcgggcctctggtggaccctggccctgttctgctggatcagtgaccgagctttctgcgag
ctgctgtcatccttcaacttcccctacctgcactgcatgtggcacatcctcatctgcctt
gctgcctacctgggctgtgtatgctttgcctactttgatgctgcctcagagattcctgag
caaggccctgtcatcaagttctggcccaatgagaaatgggccttcattggtgtcccctat
gtgtccctcctgtgtgccaacaagaaatcatcagtcaagatcacgtga
DBGET
integrated database retrieval system