Homo sapiens (human): 4294
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Entry
4294 CDS
T01001
Symbol
MAP3K10, MEKK10, MLK2, MST
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 10
KO
K04418
mitogen-activated protein kinase kinase kinase 10 [EC:
2.7.11.25
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa05016
Huntington disease
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06461
Huntington disease
nt06526
MAPK signaling
Element
N00992
Mutation-caused aberrant Htt to TNF-JNK signaling pathway
N01594
MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05016 Huntington disease
4294 (MAP3K10)
05022 Pathways of neurodegeneration - multiple diseases
4294 (MAP3K10)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
4294 (MAP3K10)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.25 mitogen-activated protein kinase kinase kinase
4294 (MAP3K10)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: TKL group
MLK family
4294 (MAP3K10)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH3_9
SH3_1
SH3_2
Pkinase_fungal
RNase_Y_N
Motif
Other DBs
NCBI-GeneID:
4294
NCBI-ProteinID:
NP_002437
OMIM:
600137
HGNC:
6849
Ensembl:
ENSG00000130758
UniProt:
Q02779
Structure
PDB
PDBj
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All DBs
Position
19:40191426..40215575
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AA seq
954 aa
AA seq
DB search
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWT
GQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGE
EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA
DTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE
VPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLR
RREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGF
EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSR
GGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHT
PIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPP
ARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRG
LSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSP
PAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPP
EPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWK
LVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
NT seq
2865 nt
NT seq
+upstream
nt +downstream
nt
atggaggaggaggagggggcggtggccaaggagtggggcacgacccccgcggggcccgtc
tggaccgcggtgttcgactacgaggcggcgggcgacgaggagctgaccctgcggaggggc
gatcgcgtccaggtgctttcccaagactgtgcggtgtccggcgacgagggctggtggacc
gggcagctccccagcggccgcgtgggcgtcttccccagcaactacgtggcccccggcgcc
cccgctgcacccgcgggcctccagctgccccaggagatccccttccacgagctgcagcta
gaggagatcatcggtgtggggggctttggcaaggtctatcgggccctgtggcgtggcgag
gaggtggcagtcaaggccgcccggctggaccctgagaaggacccggcagtgacagcggag
caggtgtgccaggaagcccggctctttggagccctgcagcaccccaacataattgccctt
aggggcgcctgcctcaaccccccacacctctgcctagtgatggagtatgcccggggtggt
gcactgagcagggtgctggcaggtcgccgggtgccacctcacgtgctggtcaactgggct
gtgcaggtggcccggggcatgaactacctacacaatgatgcccctgtgcccatcatccac
cgggacctcaagtccatcaacatcctgatcctggaggccatcgagaaccacaacctcgca
gacacggtgctcaagatcacggacttcggcctcgcccgcgagtggcacaagaccaccaag
atgagcgctgcggggacctacgcctggatggcgccggaggttatccgtctctccctcttc
tccaaaagcagtgatgtctggagcttcggggtgctgctgtgggagctgctgacgggggag
gtcccctaccgtgagatcgacgccttggccgtggcgtatggcgtggctatgaataagctg
acgctgcccattccctccacgtgccccgagccctttgcccgcctcctggaggaatgctgg
gacccagacccccacgggcggccagatttcggtagcatcttgaagcggcttgaagtcatc
gaacagtcagccctgttccagatgccactggagtccttccactcgctgcaggaagactgg
aagctggagattcagcacatgtttgatgaccttcggaccaaggagaaggagcttcggagc
cgtgaggaggagctgctgcgggcggcacaggagcagcgcttccaggaggagcagctgcgg
cggcgggagcaggagctggcagaacgtgagatggacatcgtggaacgggagctgcacctg
ctcatgtgccagctgagccaggagaagccccgggtccgcaagcgcaagggcaacttcaag
cgcagccgcctgctcaagctgcgggaaggcggcagccacatcagcctgccctctggcttt
gagcataagatcacagtccaggcctctccaactctggataagcggaaaggatccgatggg
gccagcccccctgcaagccccagcatcatcccccggctgagggccattcgcctgactccc
gtggactgtggtggcagcagcagtggcagcagcagtggaggaagtgggacatggagccgc
ggtgggcccccaaagaaggaagaactggtcgggggcaagaagaagggacgaacgtggggg
cccagctccaccctgcagaaggagcgggtgggaggagaggagaggctgaaggggctgggg
gaaggaagcaaacagtggtcatcaagtgcccccaacctgggcaagtcccccaaacacaca
cccatcgcccctggctttgccagcctcaatgagatggaggagttcgcggaggcagaggat
ggaggcagcagcgtgcccccttccccctactcgaccccgtcctacctctcagtgccactg
cctgccgagccctccccgggggcgcgggcgccgtgggagccgacgccgtccgcgcccccc
gctcggtggggacacggcgcccggcggcgctgcgacctggcgctgctaggctgcgccacg
ctgctgggggctgtgggcctgggcgccgacgtggccgaggcgcgcgcggccgacggtgag
gagcagcggcgctggctcgacggcctcttctttccccgcgccggccgcttcccgcggggc
ctcagcccacccgcgcgtccccacggccgccgcgaagacgtgggccccggcctgggcctg
gcgccctcggccaccctcgtgtcgctgtcgtccgtgtccgactgcaactccacgcgttca
ctgctgcgctctgacagtgacgaggccgcaccggccgcgccctccccaccaccctccccg
cccgcgcccacacccacgccctcgcccagcaccaaccccctggtggacctggagctggag
agcttcaagaaggacccccgccagtcgctcacgcccacccacgtcacggctgcatgcgct
gtgagccgcgggcaccggcggacgccatcggacggggcgctggggcagcgggggccgccc
gagcccgcgggccatggccctggccctcgtgaccttctggacttcccccgcctgcccgac
ccccaggccctgttcccagcccgccgccggccccctgagttcccaggccgccccaccacc
ctgacctttgccccgagacctcggccggctgccagtcgcccccgcttggacccctggaaa
ctggtctccttcggccggacactcaccatctcgcctcccagcaggccagacactccggag
agccctgggccccccagcgtgcagcccacactgctggacatggacatggaggggcagaac
caagacagcacagtgcccctgtgcggggcccacggctcccactaa
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