KEGG   Homo sapiens (human): 4535
Entry
4535              CDS       T01001                                 
Symbol
ND1, MTND1, MT-ND1
Name
(RefSeq) NADH dehydrogenase subunit 1
  KO
K03878  NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04714  Thermogenesis
hsa04723  Retrograde endocannabinoid signaling
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00142  NADH:ubiquinone oxidoreductase, mitochondria
Network
nt06460  Alzheimer disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
  Element
N00995  Electron transfer in Complex I
N00997  Mutation-caused aberrant Abeta to electron transfer in Complex I
N01042  Mutation-caused aberrant SNCA to electron transfer in Complex I
N01043  Mutation-inactivated PINK1 to electron transfer in Complex I
N01044  MPP+ to electron transfer in Complex I
N01045  Rotenone to electron transfer in Complex I
N01136  Mutation-caused aberrant TDP43 to electron transfer in Complex I
Disease
H00068  Leber hereditary optic atrophy
H00473  Mitochondrial complex I deficiency
H01347  MELAS syndrome
H01365  Leber hereditary optic neuropathy and dystonia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4535 (ND1)
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    4535 (ND1)
  09159 Environmental adaptation
   04714 Thermogenesis
    4535 (ND1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    4535 (ND1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4535 (ND1)
   05012 Parkinson disease
    4535 (ND1)
   05014 Amyotrophic lateral sclerosis
    4535 (ND1)
   05016 Huntington disease
    4535 (ND1)
   05020 Prion disease
    4535 (ND1)
   05022 Pathways of neurodegeneration - multiple diseases
    4535 (ND1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    4535 (ND1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4535 (ND1)
Enzymes [BR:hsa01000]
 7. Translocases
  7.1  Catalysing the translocation of protons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.2  NADH:ubiquinone reductase (H+-translocating)
     4535 (ND1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Mitochondrial respiratory chain complex I
    4535 (ND1)
SSDB
Motif
Pfam: NADHdh
Other DBs
NCBI-GeneID: 4535
NCBI-ProteinID: YP_003024026
OMIM: 516000
HGNC: 7455
UniProt: P03886 U5Z754
Structure
LinkDB
Position
MT:3307..4262
AA seq 318 aa
MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEP
LKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSG
WASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWP
LAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTT
IFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLAL
LMWYVSMPITISSIPPQT
NT seq 956 nt   +upstreamnt  +downstreamnt
atacccatggccaacctcctactcctcattgtacccattctaatcgcaatggcattccta
atgcttaccgaacgaaaaattctaggctatatacaactacgcaaaggccccaacgttgta
ggcccctacgggctactacaacccttcgctgacgccataaaactcttcaccaaagagccc
ctaaaacccgccacatctaccatcaccctctacatcaccgccccgaccttagctctcacc
atcgctcttctactatgaacccccctccccatacccaaccccctggtcaacctcaaccta
ggcctcctatttattctagccacctctagcctagccgtttactcaatcctctgatcaggg
tgagcatcaaactcaaactacgccctgatcggcgcactgcgagcagtagcccaaacaatc
tcatatgaagtcaccctagccatcattctactatcaacattactaataagtggctccttt
aacctctccacccttatcacaacacaagaacacctctgattactcctgccatcatgaccc
ttggccataatatgatttatctccacactagcagagaccaaccgaacccccttcgacctt
gccgaaggggagtccgaactagtctcaggcttcaacatcgaatacgccgcaggccccttc
gccctattcttcatagccgaatacacaaacattattataataaacaccctcaccactaca
atcttcctaggaacaacatatgacgcactctcccctgaactctacacaacatattttgtc
accaagaccctacttctaacctccctgttcttatgaattcgaacagcatacccccgattc
cgctacgaccaactcatacacctcctatgaaaaaacttcctaccactcaccctagcatta
cttatatgatatgtctccatacccattacaatctccagcattccccctcaaaccta

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