KEGG   NETWORK: N00997
Entry
N00997                      Network                                
Name
Mutation-caused aberrant Abeta to electron transfer in Complex I
Definition
APP* -> Abeta -> CHRNA7 -> Ca2+ -> CAPN -> CDK5R1 == CDK5 -> MAPT -| CxI -> Q
  Expanded
351v1 -> (C16515,C16514) -> 1139 -> C00076 -> (823,824) -> 8851 == 1020 -> 4137 -| (4535+4536+4537+4538+4540+4541+4719+4720+4722+4724+4725+4726+374291+4728+4723+4729+4731+4694+4695+4696+4697+4698+4700+4701+4702+4704+4705+4706+126328+55967+51079+4707+4708+4709+4710+4711+4712+4713+4714+4715+4716+54539+4717+4718) -> C00399
Class
nt06460 Alzheimer disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
823  CAPN1; calpain 1
824  CAPN2; calpain 2
8851  CDK5R1; cyclin dependent kinase 5 regulatory subunit 1
1020  CDK5; cyclin dependent kinase 5
4137  MAPT; microtubule associated protein tau
4535  ND1; NADH dehydrogenase, subunit 1 (complex I)
4536  ND2; MTND2
4537  ND3; NADH dehydrogenase, subunit 3 (complex I)
4538  ND4; NADH dehydrogenase, subunit 4 (complex I)
4540  ND5; NADH dehydrogenase, subunit 5 (complex I)
4541  ND6; NADH dehydrogenase, subunit 6 (complex I)
4719  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1
4720  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2
4722  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3
4724  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4
4725  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5
4726  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6
374291  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7
4728  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8
4723  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1
4729  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2
4731  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3
4694  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1
4695  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2
4696  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3
4697  NDUFA4; NDUFA4 mitochondrial complex associated
4698  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5
4700  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6
4701  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7
4702  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8
4704  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9
4705  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10
4706  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1
126328  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11
55967  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12
51079  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13
4707  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1
4708  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2
4709  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3
4710  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4
4711  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5
4712  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6
4713  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7
4714  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8
4715  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9
4716  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10
54539  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11
4717  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1
4718  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
C00076  Calcium cation
C00399  Ubiquinone
Reference
PMID:27994051
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
PMID:29378302
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:27873462
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:23142263
  Authors
Shukla V, Skuntz S, Pant HC
  Title
Deregulated Cdk5 activity is involved in inducing Alzheimer's disease.
  Journal
Arch Med Res 43:655-62 (2012)
DOI:10.1016/j.arcmed.2012.10.015
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