Homo sapiens (human): 4547
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Entry
4547 CDS
T01001
Symbol
MTTP, ABL, MTP
Name
(RefSeq) microsomal triglyceride transfer protein large subunit isoform 1 precursor
KO
K14463
microsomal triglyceride transfer protein large subunit
Organism
hsa
Homo sapiens (human)
Pathway
hsa04975
Fat digestion and absorption
Disease
H00160
Abetalipoproteinemia
Drug target
Lomitapide (
DG00362
):
D09637
D09638
<JP/US>
Mitratapide:
D05060
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09154 Digestive system
04975 Fat digestion and absorption
4547 (MTTP)
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Paralog
GFIT
Motif
Pfam:
MTP_lip_bd
TPR_Vitellogenin
Vitellogenin_N
Motif
Other DBs
NCBI-GeneID:
4547
NCBI-ProteinID:
NP_000244
OMIM:
157147
HGNC:
7467
UniProt:
P55157
Structure
PDB
PDBj
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All DBs
Position
4:99564130..99623997
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AA seq
894 aa
AA seq
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MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
NT seq
2685 nt
NT seq
+upstream
nt +downstream
nt
atgattcttcttgctgtgctttttctctgcttcatttcctcatattcagcttctgttaaa
ggtcacacaactggtctctcattaaataatgaccggctgtacaagctcacgtactccact
gaagttcttcttgatcggggcaaaggaaaactgcaagacagcgtgggctaccgcatttcc
tccaacgtggatgtggccttactatggaggaatcctgatggtgatgatgaccagttgatc
caaataacgatgaaggatgtaaatgttgaaaatgtgaatcagcagagaggagagaagagc
atcttcaaaggaaaaagcccatctaaaataatgggaaaggaaaacttggaagctctgcaa
agacctacgctccttcatctaatccatggaaaggtcaaagagttctactcatatcaaaat
gaggcagtggccatagaaaatatcaagagaggtctggctagcctatttcagacacagtta
agctctggaaccaccaatgaggtagatatctctggaaattgtaaagtgacctaccaggct
catcaagacaaagtgatcaaaattaaggccttggattcatgcaaaatagcgaggtctgga
tttacgaccccaaatcaggtcttgggtgtcagttcaaaagctacatctgtcaccacctat
aagatagaagacagctttgttatagctgtgcttgctgaagaaacacacaattttggactg
aatttcctacaaaccattaaggggaaaatagtatcgaagcagaaattagagctgaagaca
accgaagcaggcccaagattgatgtctggaaagcaggctgcagccataatcaaagcagtt
gattcaaagtacacggccattcccattgtggggcaggtcttccagagccactgtaaagga
tgtccttctctctcggagctctggcggtccaccaggaaatacctgcagcctgacaacctt
tccaaggctgaggctgtcagaaacttcctggccttcattcagcacctcaggactgcgaag
aaagaagagatccttcaaatactaaagatggaaaataaggaagtattacctcagctggtg
gatgctgtcacctctgctcagacctcagactcattagaagccattttggactttttggat
ttcaaaagtgacagcagcattatcctccaggagaggtttctctatgcctgtggatttgct
tctcatcccaatgaagaactcctgagagccctcattagtaagttcaaaggttctattggt
agcagtgacatcagagaaactgttatgatcatcactgggacacttgtcagaaagttgtgt
cagaatgaaggctgcaaactcaaagcagtagtggaagctaagaagttaatcctgggagga
cttgaaaaagcagagaaaaaagaggacaccaggatgtatctgctggctttgaagaatgcc
ctgcttccagaaggcatcccaagtcttctgaagtatgcagaagcaggagaagggcccatc
agccacctggctaccactgctctccagagatatgatctccctttcataactgatgaggtg
aagaagaccttaaacagaatataccaccaaaaccgtaaagttcatgaaaagactgtgcgc
actgctgcagctgctatcattttaaataacaatccatcctacatggacgtcaagaacatc
ctgctgtctattggggagcttccccaagaaatgaataaatacatgctcgccattgttcaa
gacatcctacgttttgaaatgcctgcaagcaaaattgtccgtcgagttctgaaggaaatg
gtcgctcacaattatgaccgtttctccaggagtggatcttcttctgcctacactggctac
atagaacgtagtccccgttcggcatctacttacagcctagacattctctactcgggttct
ggcattctaaggagaagtaacctgaacatctttcagtacattgggaaggctggtcttcac
ggtagccaggtggttattgaagcccaaggactggaagccttaatcgcagccacccctgac
gagggggaggagaaccttgactcctatgctggtatgtcagccatcctctttgatgttcag
ctcagacctgtcacctttttcaacggatacagtgatttgatgtccaaaatgctgtcagca
tctggcgaccctatcagtgtggtgaaaggacttattctgctaatagatcattctcaggaa
cttcagttacaatctggactaaaagccaatatagaggtccagggtggtctagctattgat
atttcaggtgcaatggagtttagcttgtggtatcgtgagtctaaaacccgagtgaaaaat
agggtgactgtggtaataaccactgacatcacagtggactcctcttttgtgaaagctggc
ctggaaaccagtacagaaacagaagcaggcttggagtttatctccacagtgcagttttct
cagtacccattcttagtttgcatgcagatggacaaggatgaagctccattcaggcaattt
gagaaaaagtacgaaaggctgtccacaggcagaggttatgtctctcagaaaagaaaagaa
agcgtattagcaggatgtgaattcccgctccatcaagagaactcagagatgtgcaaagtg
gtgtttgcccctcagccggatagtacttccagcggatggttttga
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