Homo sapiens (human): 4597
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Entry
4597 CDS
T01001
Symbol
MVD, FP17780, MDDase, MPD, POROK7
Name
(RefSeq) mevalonate diphosphate decarboxylase
KO
K01597
diphosphomevalonate decarboxylase [EC:
4.1.1.33
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00900
Terpenoid backbone biosynthesis
hsa01100
Metabolic pathways
Module
hsa_M00095
C5 isoprenoid biosynthesis, mevalonate pathway
Network
nt06034
Cholesterol biosynthesis
Element
N01635
Mevalonate pathway
Disease
H01933
Porokeratosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00900 Terpenoid backbone biosynthesis
4597 (MVD)
Enzymes [BR:
hsa01000
]
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.33 diphosphomevalonate decarboxylase
4597 (MVD)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MDD_C
MVD-like_N
GHMP_kinases_N
Motif
Other DBs
NCBI-GeneID:
4597
NCBI-ProteinID:
NP_002452
OMIM:
603236
HGNC:
7529
Ensembl:
ENSG00000167508
UniProt:
P53602
Structure
PDB
LinkDB
All DBs
Position
16:complement(88651940..88663091)
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AA seq
400 aa
AA seq
DB search
MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDF
TEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPSSLSCKVHVASVNNFPT
AAGLASSAAGYACLAYTLARVYGVESDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKD
SIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEM
ARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKV
AYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQAALAM
EPTPGGVKYIIVTQVGPGPQILDDPCAHLLGPDGLPKPAA
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atggcctcggagaagccgctggcggcagtcacttgtacagcgccggtcaacatcgcggtc
atcaagtactggggcaagcgcgatgaagagctggttctgcccatcaactcctccctgagc
gtcactctgcaccaggaccagttaaaaaccaccacaacagccgtcatcagcaaggacttc
accgaggaccggatttggctgaatggccgggaggaggatgtggggcagccgcggctgcag
gcctgcctgcgggagatccgctgcctggcccggaagcggaggaactcacgggatggggac
ccgctgccctccagcctcagctgcaaggtgcacgtggcatcggtgaacaacttccccacg
gctgcgggcctggcctcctcagcggcgggctatgcctgcctagcctacaccctggcccgt
gtctacggcgtggagagtgacctctcagaagtggctcgccggggctcaggcagcgcctgc
cggagcctgtatgggggctttgtggagtggcagatgggagagcaggccgacgggaaggac
agcatcgctcggcaagtggcccccgagtcacactggcctgaactccgcgtgctcatcctt
gtggtgagcgctgagaagaagctgacaggcagtaccgtgggcatgcgggccagtgtggag
accagccccctgcttcggttccgggccgagtccgtggtgcccgcgcgcatggcggagatg
gcccgctgcatccgggagcgagacttccccagcttcgcccagctgaccatgaaggacagc
aaccagttccacgccacctgcctcgacaccttcccgcccatctcttacctcaatgccatc
tcctggcgcatcatccacctggtgcaccgcttcaacgcccaccacggggacaccaaggtg
gcgtacacctttgacgcgggccccaatgccgtgatcttcaccctggacgacactgtggct
gagtttgtggctgctgtgtggcacggctttcccccaggctcgaatggagacacgtttctg
aaggggctgcaggtgaggccggcccctctctcagctgagcttcaggctgcgctggccatg
gagccgacccccggtggggtcaaatacatcattgtcactcaggtggggccagggcctcaa
atcctggatgacccctgcgcccacctcctgggtcctgacggcctgccgaagccagctgcc
tga
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