KEGG NETWORK: N01635

NETWORK: N01635

Entry

N01635                      Network

Name

Mevalonate pathway

Definition

Acetyl-CoA -- ACAT >> HMGCS >> HMGCR >> MVK >> PMVK >> MVD >> IDI >> (FDPS,GGPS1) -> Farnesyl-PP

Expanded

C00024 -- (38,39) >> (3157,3158) >> 3156 >> 4598 >> 10654 >> 4597 >> (3422,91734) >> (2224,9453) -> C00448

Class

nt06034 Cholesterol biosynthesis

Type

Reference

Pathway

hsa00900

Terpenoid backbone biosynthesis

Gene

38	ACAT1; acetyl-CoA acetyltransferase 1

39	ACAT2; acetyl-CoA acetyltransferase 2

3157	HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase 1

3158	HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2

3156	HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase

4598	MVK; mevalonate kinase

10654

PMVK; phosphomevalonate kinase

4597	MVD; mevalonate diphosphate decarboxylase

3422	IDI1; isopentenyl-diphosphate delta isomerase 1

91734

IDI2; isopentenyl-diphosphate delta isomerase 2

2224	FDPS; farnesyl diphosphate synthase

9453	GGPS1; geranylgeranyl diphosphate synthase 1

Metabolite

C00024

Acetyl-CoA

C00448

trans,trans-Farnesyl diphosphate

Reference

PMID:17467679

Authors

Buhaescu I, Izzedine H

Title

Mevalonate pathway: a review of clinical and therapeutical implications.

Journal

Clin Biochem 40:575-84 (2007)
DOI:10.1016/j.clinbiochem.2007.03.016

Reference

PMID:26202976

Authors

Zhang Z, Li C, Wu F, Ma R, Luan J, Yang F, Liu W, Wang L, Zhang S, Liu Y, Gu J, Hua W, Fan M, Peng H, Meng X, Song N, Bi X, Gu C, Zhang Z, Huang Q, Chen L, Xiang L, Xu J, Zheng Z, Jiang Z

Title

Genomic variations of the mevalonate pathway in porokeratosis.

Journal

Elife 4:e06322 (2015)
DOI:10.7554/eLife.06322

LinkDB

DBGET integrated database retrieval system