Homo sapiens (human): 4598
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Entry
4598 CDS
T01001
Symbol
MVK, LRBP, MK, MVLK, POROK3
Name
(RefSeq) mevalonate kinase
KO
K00869
mevalonate kinase [EC:
2.7.1.36
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00900
Terpenoid backbone biosynthesis
hsa01100
Metabolic pathways
hsa04146
Peroxisome
Module
hsa_M00095
C5 isoprenoid biosynthesis, mevalonate pathway
Network
nt06034
Cholesterol biosynthesis
Element
N01635
Mevalonate pathway
Disease
H00206
Mevalonate kinase deficiency
H01933
Porokeratosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00900 Terpenoid backbone biosynthesis
4598 (MVK)
09140 Cellular Processes
09141 Transport and catabolism
04146 Peroxisome
4598 (MVK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.36 mevalonate kinase
4598 (MVK)
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Gene cluster
GFIT
Motif
Pfam:
GHMP_kinases_N
GHMP_kinases_C
GalKase_gal_bdg
MVD-like_N
Motif
Other DBs
NCBI-GeneID:
4598
NCBI-ProteinID:
NP_000422
OMIM:
251170
HGNC:
7530
Ensembl:
ENSG00000110921
UniProt:
Q03426
B2RDU6
Structure
PDB
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All DBs
Position
12:109573272..109598125
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AA seq
396 aa
AA seq
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MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
NT seq
1191 nt
NT seq
+upstream
nt +downstream
nt
atgttgtcagaagtcctactggtgtctgctccggggaaagtcatccttcatggagaacat
gccgtggtacatggcaaggtagcactggctgtatccttgaacttgagaacattcctccgg
cttcaaccccacagcaatgggaaagtggacctcagcttacccaacattggtatcaagcgg
gcctgggatgtggccaggcttcagtcactggacacaagctttctggagcaaggtgatgtc
acaacacccacctcagagcaagtggagaagctaaaggaggttgcaggcttgcctgacgac
tgtgctgtcaccgagcgcctggctgtgctggcctttctttacttatacctgtccatctgc
cggaagcagagggccctgccgagcctggatatcgtagtgtggtcggagctgccccccggg
gcgggcttgggctccagcgccgcctactcggtgtgtctggcagcagccctcctgactgtg
tgcgaggagatcccaaacccgctgaaggacggggattgcgtcaacaggtggaccaaggag
gatttggagctaattaacaagtgggccttccaaggggagagaatgattcacgggaacccc
tccggagtggacaatgctgtcagcacctggggaggagccctccgataccatcaagggaag
atttcatccttaaagaggtcgccagctctccagatcctgctgaccaacaccaaagtccct
cgcaataccagggcccttgtggctggcgtcagaaacaggctgctcaagttcccagagatc
gtggcccccctcctgacctcaatagatgccatctccctggagtgtgagcgcgtgctggga
gagatgggggaagccccagccccggagcagtacctcgtgctggaagagctcattgacatg
aaccagcaccatctgaatgccctcggcgtgggccacgcctctctggaccagctctgccag
gtgaccagggcccgcggacttcacagcaagctgactggcgcaggcggtggtggctgtggc
atcacactcctcaagccagggctggagcagccagaagtggaggccacgaagcaggccctg
accagctgtggctttgactgcttggaaaccagcatcggtgcccccggcgtctccatccac
tcagccacctccctggacagccgagtccagcaagccctggatggcctctga
DBGET
integrated database retrieval system