KEGG   Homo sapiens (human): 4967
Entry
4967              CDS       T01001                                 
Symbol
OGDH, AKGDH, E1k, E1o, HsOGDH, KGD1, OGDC, OGDH-E1, OGDH2, OGDHD
Name
(RefSeq) oxoglutarate dehydrogenase
  KO
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00785  Lipoic acid metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01210  2-Oxocarboxylic acid metabolism
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Network
nt06031  Citrate cycle and pyruvate metabolism
nt06032  Lipoic acid metabolism
  Element
N01609  Citrate cycle, second carbon oxidation 1
Disease
H01022  Diseases of the tricarboxylic acid cycle
H02006  Alpha-ketoglutarate dehydrogenase complex deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    4967 (OGDH)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    4967 (OGDH)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2  oxoglutarate dehydrogenase (succinyl-transferring)
     4967 (OGDH)
SSDB
Motif
Pfam: E1_dh OxoGdeHyase_C Transket_pyr 2-oxogl_dehyd_N GGA_N-GAT R2K_2
Other DBs
NCBI-GeneID: 4967
NCBI-ProteinID: NP_002532
OMIM: 613022
HGNC: 8124
Ensembl: ENSG00000105953
UniProt: Q02218 B4E3E9
Structure
LinkDB
Position
7:44606627..44709066
AA seq 1023 aa
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEE
MYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNV
DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES
DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET
PGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN
GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR
VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV
YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP
EAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY
AELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPR
SMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMA
FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL
SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP
HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFH
VLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKR
LLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEH
KNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDVFK
NFS
NT seq 3072 nt   +upstreamnt  +downstreamnt
atgtttcatttaaggacttgtgctgctaagttgaggccattgacggcttcccagactgtt
aagacattttcacaaaacagaccagcagcagctaggacatttcaacagattcggtgctat
tctgcacctgttgctgctgagccctttctcagtgggactagttcgaactatgtggaggag
atgtactgtgcttggctggaaaaccccaaaagtgtacataagtcatgggacatttttttt
cgcaacacgaatgccggagccccaccgggcactgcctaccagagtccccttcccctgagc
cgaggctccctggctgctgtggcccatgcacagtccctggtagaagcacagcccaacgtg
gacaagctcgtggaggaccacctggcagtgcagtcgctcatcagggcatatcagatacga
gggcaccatgtagcacagctggaccccctggggattttggatgctgatctggactcctcc
gtgcccgctgacattatctcatccacagacaaacttgggttctatggcctggatgagtct
gacctcgacaaggtcttccacttgcccaccaccactttcatcgggggacaggaatcagca
cttcctctgcgggagatcatccgtcggctggagatggcctactgccagcatattggggtg
gagttcatgttcatcaatgacctggagcagtgccagtggatccggcagaagtttgagacc
cctgggatcatgcagttcacaaatgaggagaaacggaccctgctggccaggcttgtgcgg
tccaccaggtttgaggagttcctacagcggaagtggtcctctgagaagcgctttggtcta
gaaggctgcgaggtactgatccctgccctcaagaccatcattgacaagtctagtgagaat
ggcgtggactacgtgatcatgggcatgccacacagagggcggctgaacgtgcttgcaaat
gtcatcaggaaggagctggaacagatcttctgtcaattcgattcaaagctggaggcagct
gatgagggctccggagatgtgaagtaccacctgggcatgtatcaccgcaggatcaatcgt
gtcaccgacaggaacattaccttgtccttggtggccaacccttcccaccttgaggccgct
gaccccgtggtgatgggcaagaccaaagccgaacagttttactgtggcgacactgaaggg
aaaaaggtcatgtccatcctgttgcatggggatgctgcatttgctggccagggcattgtg
tacgagaccttccacctcagcgacctgccatcctacacaactcatggcaccgtgcacgtg
gtcgtcaacaaccagatcggcttcaccaccgaccctcggatggcccgctcctccccctac
cccactgacgtggcccgagtggtgaatgcccccattttccacgtgaactcagatgacccc
gaggctgtcatgtacgtgtgcaaagtggcggccgagtggaggagcaccttccacaaggac
gtggttgtcgatttggtgtgttaccggcgcaacggccacaacgagatggatgagcccatg
ttcacgcagccgctcatgtacaagcagatccgcaagcagaagcctgtgttacagaagtac
gctgagctgctggtgtcgcagggtgtggtcaaccagcctgagtatgaggaggaaatttcc
aagtatgataagatctgtgaggaagcttttgccagatctaaagatgagaagatcttgcac
attaagcactggctggactctccctggcctggcttcttcaccctggacgggcagcccagg
agcatgtcctgcccctccacgggtctgacggaggatattctgacacacatcgggaatgtg
gctagttctgtgcctgtggaaaactttactattcatggagggctgagccggatcttgaag
actcgtggggaaatggtgaagaaccggactgtggactgggctctagcggagtacatggcg
tttggctcgctcctgaaggagggcatccacattcggctgagcggccaggacgtggagcgg
ggcacattcagccaccgccaccatgtgctccatgaccagaatgtggacaagagaacctgc
atccccatgaaccatctctggcccaatcaggccccctatactgtgtgcaacagctcactg
tctgagtacggcgtgctgggctttgagctgggcttcgccatggccagtcctaatgccctg
gtcctctgggaagcccaatttggtgacttccacaacacggcccagtgtatcatcgaccag
ttcatctgcccgggacaagccaagtgggtgcggcagaatggcatcgtgttgctgctgccc
catggcatggagggcatgggtccagaacattcctccgcccgcccagagcggttcttgcag
atgtgcaacgatgacccagatgtcctgccagaccttaaagaagccaacttcgacatcaat
cagctatatgactgcaattgggttgttgtcaactgctccactcctggcaacttcttccac
gtgctacgacgccagatcctgctgccattccggaagccgttaattatcttcacccccaaa
tccctgttgcgccaccccgaggccagatccagctttgatgagatgcttccaggaacccac
ttccagcgggtgatcccagaagatggccctgcagctcagaacccagaaaatgtcaaaagg
cttctcttctgcaccggcaaagtgtattatgacctcacccgggagcgcaaagcacgcgac
atggtggggcaggtggccatcacaaggattgagcagctgtcgccattcccctttgacctc
ctgctgaaggaggtgcagaagtaccccaatgctgagctggcctggtgccaggaggagcac
aagaaccaaggctactatgactacgtgaagccaagacttcggaccaccatcagccgcgcc
aagcccgtctggtatgccggccgggacccagcggctgctccagccaccggcaacaagaag
acccacctgacggagctgcagcgcctcctggacacggccttcgacctggacgtcttcaag
aacttctcgtag

DBGET integrated database retrieval system