Homo sapiens (human): 5054 Help Entry 5054              CDS       T01001                                  Symbol SERPINE1, PAI, PAI-1, PAI1, PLANH1 Name (RefSeq) serpin family E member 1   KO K03982   plasminogen activator inhibitor 1 Organism hsa  Homo sapiens (human) Pathway hsa04066   HIF-1 signaling pathway hsa04115   p53 signaling pathway hsa04218   Cellular senescence hsa04371   Apelin signaling pathway hsa04390   Hippo signaling pathway hsa04610   Complement and coagulation cascades hsa04933   AGE-RAGE signaling pathway in diabetic complications hsa05142   Chagas disease Network nt06514  Coagulation cascade   Element N01524   Regulation of fibrinolytic system, PAI Disease H01106   Plasminogen activator inhibitor type 1 deficiency H01529   Avascular necrosis of femoral head Drug target Aleplasinin:  D08656 Diaplasinin:  D03766 Tiplasinin:  D06160 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04390 Hippo signaling pathway     5054 (SERPINE1)    04371 Apelin signaling pathway     5054 (SERPINE1)    04066 HIF-1 signaling pathway     5054 (SERPINE1)  09140 Cellular Processes   09143 Cell growth and death    04115 p53 signaling pathway     5054 (SERPINE1)    04218 Cellular senescence     5054 (SERPINE1)  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     5054 (SERPINE1)  09160 Human Diseases   09174 Infectious disease: parasitic    05142 Chagas disease     5054 (SERPINE1)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     5054 (SERPINE1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     5054 (SERPINE1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     5054 (SERPINE1)    00536 Glycosaminoglycan binding proteins [BR:hsa00536]     5054 (SERPINE1) Peptidases and inhibitors [BR:hsa01002]  Peptidase inhibitors   Family I4: serpin family    5054 (SERPINE1) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    5054 (SERPINE1) Glycosaminoglycan binding proteins [BR:hsa00536]  Heparan sulfate / Heparin   Coagulation and fibrinolysis    5054 (SERPINE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Serpin Motif Other DBs NCBI-GeneID:  5054 NCBI-ProteinID:  NP_000593 OMIM:  173360 HGNC:  8583 Ensembl:  ENSG00000106366 UniProt:  P05121 Structure PDBPDBj LinkDB All DBs Position 7:101127104..101139247 Genome browser AA seq 402 aa AA seqDB search MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP NT seq 1209 nt NT seq  +upstreamnt  +downstreamnt atgcagatgtctccagccctcacctgcctagtcctgggcctggcccttgtctttggtgaa gggtctgctgtgcaccatcccccatcctacgtggcccacctggcctcagacttcggggtg agggtgtttcagcaggtggcgcaggcctccaaggaccgcaacgtggttttctcaccctat ggggtggcctcggtgttggccatgctccagctgacaacaggaggagaaacccagcagcag attcaagcagctatgggattcaagattgatgacaagggcatggcccccgccctccggcat ctgtacaaggagctcatggggccatggaacaaggatgagatcagcaccacagacgcgatc ttcgtccagcgggatctgaagctggtccagggcttcatgccccacttcttcaggctgttc cggagcacggtcaagcaagtggacttttcagaggtggagagagccagattcatcatcaat gactgggtgaagacacacacaaaaggtatgatcagcaacttgcttgggaaaggagccgtg gaccagctgacacggctggtgctggtgaatgccctctacttcaacggccagtggaagact cccttccccgactccagcacccaccgccgcctcttccacaaatcagacggcagcactgtc tctgtgcccatgatggctcagaccaacaagttcaactatactgagttcaccacgcccgat ggccattactacgacatcctggaactgccctaccacggggacaccctcagcatgttcatt gctgccccttatgaaaaagaggtgcctctctctgccctcaccaacattctgagtgcccag ctcatcagccactggaaaggcaacatgaccaggctgccccgcctcctggttctgcccaag ttctccctggagactgaagtcgacctcaggaagcccctagagaacctgggaatgaccgac atgttcagacagtttcaggctgacttcacgagtctttcagaccaagagcctctccacgtc gcgcaggcgctgcagaaagtgaagatcgaggtgaacgagagtggcacggtggcctcctca tccacagctgtcatagtctcagcccgcatggcccccgaggagatcatcatggacagaccc ttcctctttgtggtccggcacaaccccacaggaacagtccttttcatgggccaagtgatg gaaccctga

Homo sapiens (human): 5055 Help Entry 5055              CDS       T01001                                  Symbol SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2 Name (RefSeq) serpin family B member 2   KO K19821   plasminogen activator inhibitor 2 Organism hsa  Homo sapiens (human) Pathway hsa04610   Complement and coagulation cascades Network nt06514  Coagulation cascade   Element N01524   Regulation of fibrinolytic system, PAI Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     5055 (SERPINB2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     5055 (SERPINB2) Peptidases and inhibitors [BR:hsa01002]  Peptidase inhibitors   Family I4: serpin family    5055 (SERPINB2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Serpin GDE_C Motif Other DBs NCBI-GeneID:  5055 NCBI-ProteinID:  NP_001137290 OMIM:  173390 HGNC:  8584 Ensembl:  ENSG00000197632 UniProt:  P05120 Structure PDBPDBj LinkDB All DBs Position 18:63887705..63903888 Genome browser AA seq 415 aa AA seqDB search MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQF NEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGN YLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGK IPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREK LNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKM AEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMV DVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP NT seq 1248 nt NT seq  +upstreamnt  +downstreamnt atggaggatctttgtgtggcaaacacactctttgccctcaatttattcaagcatctggca aaagcaagccccacccagaacctcttcctctccccatggagcatctcgtccaccatggcc atggtctacatgggctccaggggcagcaccgaagaccagatggccaaggtgcttcagttt aatgaagtgggagccaatgcagttacccccatgactccagagaactttaccagctgtggg ttcatgcagcagatccagaagggtagttatcctgatgcgattttgcaggcacaagctgca gataaaatccattcatccttccgctctctcagctctgcaatcaatgcatccacagggaat tatttactggaaagtgtcaataagctgtttggtgagaagtctgcgagcttccgggaagaa tatattcgactctgtcagaaatattactcctcagaaccccaggcagtagacttcctagaa tgtgcagaagaagctagaaaaaagattaattcctgggtcaagactcaaaccaaaggcaaa atcccaaacttgttacctgaaggttctgtagatggggataccaggatggtcctggtgaat gctgtctacttcaaaggaaagtggaaaactccatttgagaagaaactaaatgggctttat cctttccgtgtaaactcggctcagcgcacacctgtacagatgatgtacttgcgtgaaaag ctaaacattggatacatagaagacctaaaggctcagattctagaactcccatatgctgga gatgttagcatgttcttgttgcttccagatgaaattgccgatgtgtccactggcttggag ctgctggaaagtgaaataacctatgacaaactcaacaagtggaccagcaaagacaaaatg gctgaagatgaagttgaggtatacataccccagttcaaattagaagagcattatgaactc agatccattctgagaagcatgggcatggaggacgccttcaacaagggacgggccaatttc tcagggatgtcggagaggaatgacctgtttctttctgaagtgttccaccaagccatggtg gatgtgaatgaggagggcactgaagcagccgctggcacaggaggtgttatgacagggaga actggacatggaggcccacagtttgtggcagatcatccttttctttttcttattatgcat aagataaccaactgcattttatttttcggcagattttcctcaccctaa

Homo sapiens (human): 5104 Help Entry 5104              CDS       T01001                                  Symbol SERPINA5, PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI Name (RefSeq) serpin family A member 5   KO K03913   protein C inhibitor Organism hsa  Homo sapiens (human) Pathway hsa04610   Complement and coagulation cascades Network nt06514  Coagulation cascade   Element N01524   Regulation of fibrinolytic system, PAI Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     5104 (SERPINA5)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     5104 (SERPINA5)   09183 Protein families: signaling and cellular processes    00536 Glycosaminoglycan binding proteins [BR:hsa00536]     5104 (SERPINA5) Peptidases and inhibitors [BR:hsa01002]  Peptidase inhibitors   Family I4: serpin family    5104 (SERPINA5) Glycosaminoglycan binding proteins [BR:hsa00536]  Heparan sulfate / Heparin   Coagulation and fibrinolysis    5104 (SERPINA5) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Serpin YfdX Motif Other DBs NCBI-GeneID:  5104 NCBI-ProteinID:  NP_000615 OMIM:  601841 HGNC:  8723 Ensembl:  ENSG00000188488 UniProt:  P05154 B4DDH1 Structure PDBPDBj LinkDB All DBs Position 14:94581426..94593118 Genome browser AA seq 406 aa AA seqDB search MQLFLLLCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAA PSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQ PRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQT KGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSRED QYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQLE LYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGT RAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNILFLGKVNRP NT seq 1221 nt NT seq  +upstreamnt  +downstreamnt atgcagctcttcctcctcttgtgcctggtgcttctcagccctcagggggcctcccttcac cgccaccacccccgggagatgaagaagagagtcgaggacctccatgtaggtgccacggtg gcccccagcagcagaagggactttacctttgacctctacagggccttggcttccgctgcc cccagccagagcatcttcttctcccctgtgagcatctccatgagcctggccatgctctcc ctgggggctgggtccagcacaaagatgcagatcctggagggcctgggcctcaacctccag aaaagctcagagaaggagctgcacagaggctttcagcagctccttcaggaactcaaccag cccagagatggcttccagctgagcctcggcaatgcccttttcaccgacctggtggtagac ctgcaggacaccttcgtaagtgccatgaagacgctgtacctggcagacactttccctacc aactttagggactctgcaggggccatgaagcagatcaatgattatgtggcaaagcaaacg aagggcaagattgtggacttgcttaagaacctcgatagcaatgcggtcgtgatcatggtg aattacatcttctttaaagctaagtgggagacaagcttcaaccacaaaggcacccaagag caagacttctacgtgacctcggagactgtggtgcgggtacccatgatgagccgcgaggat cagtatcactacctcctggaccggaacctctcctgcagggtggtgggggtcccctaccaa ggcaatgccacggctttgttcattctccccagtgagggaaagatgcagcaggtggagaat ggactgagtgagaaaacgctgaggaagtggcttaagatgttcaaaaagaggcagctcgag ctttaccttcccaaattctccattgagggctcctatcagctggagaaagtcctccccagt ctggggatcagtaacgtcttcacctcccatgctgatctgtccggcatcagcaaccactca aatatccaggtgtctgagatggtgcacaaagctgtggtggaggtggacgagtcgggaacc agagcagcggcagccacggggacaatattcactttcaggtcggcccgcctgaactctcag aggctagtgttcaacaggccctttctgatgttcattgtggataacaacatcctcttcctt ggcaaagtgaaccgcccctga

Homo sapiens (human): 5270 Help Entry 5270              CDS       T01001                                  Symbol SERPINE2, GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI Name (RefSeq) serpin family E member 2   KO K16643   glia-derived nexin Organism hsa  Homo sapiens (human) Pathway hsa04610   Complement and coagulation cascades Network nt06514  Coagulation cascade   Element N01524   Regulation of fibrinolytic system, PAI Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     5270 (SERPINE2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     5270 (SERPINE2)   09183 Protein families: signaling and cellular processes    00536 Glycosaminoglycan binding proteins [BR:hsa00536]     5270 (SERPINE2) Peptidases and inhibitors [BR:hsa01002]  Peptidase inhibitors   Family I4: serpin family    5270 (SERPINE2) Glycosaminoglycan binding proteins [BR:hsa00536]  Heparan sulfate / Heparin   Coagulation and fibrinolysis    5270 (SERPINE2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Serpin Motif Other DBs NCBI-GeneID:  5270 NCBI-ProteinID:  NP_006207 OMIM:  177010 HGNC:  8951 Ensembl:  ENSG00000135919 UniProt:  P07093 Structure PDBPDBj LinkDB All DBs Position 2:complement(223975045..224039286) Genome browser AA seq 398 aa AA seqDB search MNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIAS VLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNAS EIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTR LVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYN FIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVA QTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTA ILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP NT seq 1197 nt NT seq  +upstreamnt  +downstreamnt atgaactggcatctccccctcttcctcttggcctctgtgacgctgccttccatctgctcc cacttcaatcctctgtctctcgaggaactaggctccaacacggggatccaggttttcaat cagattgtgaagtcgaggcctcatgacaacatcgtgatctctccccatgggattgcgtcg gtcctggggatgcttcagctgggggcggacggcaggaccaagaagcagctcgccatggtg atgagatacggcgtaaatggagttggtaaaatattaaagaagatcaacaaggccatcgtc tccaagaagaataaagacattgtgacagtggctaacgccgtgtttgttaagaatgcctct gaaattgaagtgccttttgttacaaggaacaaagatgtgttccagtgtgaggtccggaat gtgaactttgaggatccagcctctgcctgtgattccatcaatgcatgggttaaaaatgaa accagggatatgattgacaatctgctgtccccagatcttattgatggtgtgctcaccaga ctggtcctcgtcaacgcagtgtatttcaagggtctgtggaaatcacggttccaacccgag aacacaaagaaacgcactttcgtggcagccgacgggaaatcctatcaagtgccaatgctg gcccagctctccgtgttccggtgtgggtcgacaagtgcccccaatgatttatggtacaac ttcattgaactgccctaccacggggaaagcatcagcatgctgattgcactgccgactgag agctccactccgctgtctgccatcatcccacacatcagcaccaagaccatagacagctgg atgagcatcatggtgcccaagagggtgcaggtgatcctgcccaagttcacagctgtagca caaacagatttgaaggagccgctgaaagttcttggcattactgacatgtttgattcatca aaggcaaattttgcaaaaataacaacagggtcagaaaacctccatgtttctcatatcttg caaaaagcaaaaattgaagtcagtgaagatggaaccaaagcttcagcagcaacaactgca attctcattgcaagatcatcgcctccctggtttatagtagacagaccttttctgtttttc atccgacataatcctacaggtgctgtgttattcatggggcagataaacaaaccctga

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