KEGG T01001: 50964

Homo sapiens (human): 50964

Entry

50964             CDS       T01001

Symbol

SOST, CDD, DAND6, SOST1, VBCH

Name

(RefSeq) sclerostin

K16834

sclerostin

Organism

hsa Homo sapiens (human)

Pathway

hsa04310

Wnt signaling pathway

hsa04928

Parathyroid hormone synthesis, secretion and action

Network

nt06505 WNT signaling

Element

N01441

Wnt signaling modulation, SOST/LRP4

Disease

H00486

Sclerosteosis

H01774

Hyperostosis corticalis generalisata

H02609

Craniodiaphyseal dysplasia

Drug target

Blosozumab:

D10094

Romosozumab:

D10156<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    50964 (SOST)
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    50964 (SOST)

SSDB

Motif

Pfam:

Sclerostin DAN Cys_knot

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:complement(43753738..43758791)

AA seq 213 aa
MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAE
NGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIG
RGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELK
DFGTEAARPQKGRKPRPRARSAKANQAELENAY

NT seq 642 nt +upstreamnt +downstreamnt
atgcagctcccactggccctgtgtctcgtctgcctgctggtacacacagccttccgtgta
gtggagggccaggggtggcaggcgttcaagaatgatgccacggaaatcatccccgagctc
ggagagtaccccgagcctccaccggagctggagaacaacaagaccatgaaccgggcggag
aacggagggcggcctccccaccacccctttgagaccaaagacgtgtccgagtacagctgc
cgcgagctgcacttcacccgctacgtgaccgatgggccgtgccgcagcgccaagccggtc
accgagctggtgtgctccggccagtgcggcccggcgcgcctgctgcccaacgccatcggc
cgcggcaagtggtggcgacctagtgggcccgacttccgctgcatccccgaccgctaccgc
gcgcagcgcgtgcagctgctgtgtcccggtggtgaggcgccgcgcgcgcgcaaggtgcgc
ctggtggcctcgtgcaagtgcaagcgcctcacccgcttccacaaccagtcggagctcaag
gacttcgggaccgaggccgctcggccgcagaagggccggaagccgcggccccgcgcccgg
agcgccaaagccaaccaggccgagctggagaacgcctactag

DBGET integrated database retrieval system