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ENTRY	nt06505
Name	WNT signaling
Category	Pathway view; Signal transduction
Pathway	hsa04310 Wnt signaling pathway
Disease	H00485 Robinow syndrome
Display	drug-target relation   disease type

N00056        WNT → (FZD+LRP5/6) → (DVL+FRAT) ⊣ (GSK3B+AXIN+APC) ⊣ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1)     BMND16/OI15     WNT1*     TETAMS1     WNT3*     Fuhrmann syndrome/AARRS     WNT7A*     STHAG4/OODD/SSPS     WNT10A*     STHAG8/SHFM6     WNT10B*     OMOD2         FZD2*     MCOPCB11         FZD5*     NDNC1         FZD6*     BMND1/VBCH2/OPTA1/OPPG/EVR4         LRP5*     STHAG7         LRP6*     ODCRCS                 AXIN2*     HCC                 AXIN*     CRC/GC                 APC*     CRC/HCC/EC                     CTNNB1* ↗ N00175    KSHV             LANA ⊣ GSK3B ⊣ CTNNB1 → TCF/LEF ⇒ CCND1 N01124    Salmonella                 AvrA → CTNNB1 → TCF/LEF ⇒ MYC N01443    PORCN → WNT     FDH PORCN* N01442    (SFRP,WIF1,CER1,NO.. ⊣ WNT     PYL SFRP4* N01441        (SOST+LRP4) ⊣ (FZD+LRP5/6)     SOST1/CDD     SOST*     SOST2/CLSS     LRP4* N01440    (RSPO+LGR4/5/6)) ⊣ (ZNRF3,RNF43) ⊣ FZD     TETAMS2 RSPO2*     NDNC4 RSPO4*     BMND17 LGR4* N01427        WNT5A → (FZD,(ROR1,ROR2)) → DVL     DRS1     WNT5A*     RRS1/BDB1         ROR2*     DRS2             DVL1*     DRS3             DVL3* N01444    RRS2         NXN* ⊣ DVL

		Disease name	Disease category
BMND16/OI15	H01593	Osteoporosis	Musculoskeletal disease
	H00506	Osteogenesis imperfecta	Congenital malformation
TETAMS1	H00636	Tetra-amelia syndrome	Congenital malformation
Fuhrmann syndrome/AARRS	H00846	Fuhrmann syndrome	Congenital malformation
	H00847	Al-Awadi/Raas-Rothschild syndrome	Congenital malformation
STHAG4/OODD/SSPS	H00625	Tooth agenesis	Congenital malformation
	H00646	Odontoonychodermal dysplasia	Congenital malformation
	H00781	Schopf-Schulz-Passarge syndrome	Congenital malformation
STHAG8/SHFM6	H00625	Tooth agenesis	Congenital malformation
	H00471	Split-hand/foot malformation	Congenital malformation
OMOD2	H02154	Omodysplasia	Congenital malformation
MCOPCB11	H01027	Microphthalmia	Congenital malformation
NDNC1	H01307	Nonsyndromic congenital nail disorder	Skin disease
BMND1/VBCH2/OPTA1/OPPG/EVR4	H01593	Osteoporosis	Musculoskeletal disease
	H01774	Hyperostosis corticalis generalisata	Musculoskeletal disease
	H00436	Osteopetrosis	Congenital malformation
	H00451	Osteoporosis-pseudoglioma syndrome	Congenital malformation
	H00589	Familial exudative vitreoretinopathy	Nervous system disease
STHAG7	H00625	Tooth agenesis	Congenital malformation
ODCRCS	H00857	Oligodontia-colorectal cancer syndrome	Congenital malformation
HCC	H00048	Hepatocellular carcinoma	Cancer
CRC/GC	H00020	Colorectal cancer	Cancer
	H00018	Gastric cancer	Cancer
CRC/HCC/EC	H00020	Colorectal cancer	Cancer
	H00048	Hepatocellular carcinoma	Cancer
	H00026	Endometrial cancer	Cancer
KSHV	H00041	Kaposi sarcoma	Cancer
Salmonella	H00113	Salmonellosis	Bacterial infectious disease
FDH	H00949	Focal dermal hypoplasia	Congenital malformation
PYL	H00479	Metaphyseal dysplasias	Congenital malformation
SOST1/CDD	H00486	Sclerosteosis	Congenital malformation
	H02609	Craniodiaphyseal dysplasia	Musculoskeletal disease
SOST2/CLSS	H00486	Sclerosteosis	Congenital malformation
	H00853	Cenani-Lenz syndactyly syndrome	Congenital malformation
TETAMS2	H00636	Tetra-amelia syndrome	Congenital malformation
NDNC4	H01307	Nonsyndromic congenital nail disorder	Skin disease
BMND17	H01593	Osteoporosis	Musculoskeletal disease
DRS1	H00485	Robinow syndrome	Congenital malformation
RRS1/BDB1	H00485	Robinow syndrome	Congenital malformation
	H00482	Brachydactyly	Congenital malformation
DRS2	H00485	Robinow syndrome	Congenital malformation
DRS3	H00485	Robinow syndrome	Congenital malformation
RRS2	H00485	Robinow syndrome	Congenital malformation