Homo sapiens (human): 5145
Help
Entry
5145 CDS
T01001
Symbol
PDE6A, CGPR-A, PDEA, RP43
Name
(RefSeq) phosphodiesterase 6A
KO
K08718
rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [EC:
3.1.4.35
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04744
Phototransduction
Disease
H00527
Retinitis pigmentosa
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5145 (PDE6A)
09150 Organismal Systems
09157 Sensory system
04744 Phototransduction
5145 (PDE6A)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
5145 (PDE6A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDEase_I
GAF
GAF_2
LON_substr_bdg
HD-CE
Motif
Other DBs
NCBI-GeneID:
5145
NCBI-ProteinID:
NP_000431
OMIM:
180071
HGNC:
8785
Ensembl:
ENSG00000132915
UniProt:
P16499
LinkDB
All DBs
Position
5:complement(149857953..149944793)
Genome browser
AA seq
860 aa
AA seq
DB search
MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
QPGGNPSPGGATTSKSCCIQ
NT seq
2583 nt
NT seq
+upstream
nt +downstream
nt
atgggcgaggtgacagcagaggaggtggagaagttcctggactcgaatattggctttgcc
aaacagtactacaacctccactaccgggccaagctcatctccgacctccttggggccaag
gaggctgccgtggacttcagcaactaccactccccgagcagcatggaggagagcgaaatc
atctttgatctcctgcgggactttcaggagaatttacagacagagaaatgcatcttcaat
gtcatgaagaagctgtgcttcctcctgcaggcagaccgcatgagcctgttcatgtaccgg
acccgcaatggcatcgcagagctggccaccaggcttttcaatgtccacaaggatgctgtc
ctcgaggactgcctggtgatgcccgaccaagagatcgtcttccctttggacatgggcatc
gtgggccatgtcgcacactctaagaagattgctaacgtccccaacacagaggaggatgag
catttctgtgactttgtggacatcctcacagagtacaagaccaagaacatcttggcttcc
cccataatgaatgggaaggatgtggtggccataatcatggctgtgaataaagtggatgga
tcccacttcaccaagagagatgaagagattcttctcaagtacctcaattttgcaaatcta
atcatgaaggtgtaccacctgagttacctgcacaactgtgaaactcgacgtggccagata
ctgctgtggtctgggagcaaagtctttgaagaacttacggacatcgaacgacagttccac
aaagccctgtacacagtccgtgctttcctcaactgtgacagatactctgtgggtctctta
gacatgaccaagcagaaggaattttttgatgtgtggccggttctgatgggtgaagttcca
ccttactctggtcccaggactccggatggaagagaaattaacttttacaaggtcattgac
tacatcctgcatggcaaagaggacatcaaagtcatcccgaatccacctcctgaccattgg
gctttagtaagcggtctcccagcttatgttgcccagaatggcctgatttgcaacatcatg
aatgcgcctgcggaggacttttttgcatttcagaaagaacctctggatgagtctggatgg
atgattaaaaatgtgctttcaatgccgattgtgaacaagaaggaagaaattgttggagtg
gccacattttacaatcgtaaagatgggaagccctttgatgaaatggatgagacgctcatg
gagtctttgactcaatttctgggctggtctgtcttaaatcctgacacctatgagtcaatg
aataaacttgaaaataggaaggatattttccaggacatagtaaaatatcatgtgaagtgt
gacaatgaagaaattcagaaaatcttgaaaaccagagaggtgtatgggaaggagccatgg
gagtgtgaggaagaggagctggctgagatcctgcaagcggagctgccagatgcagataaa
tacgaaattaataaatttcacttcagtgacttacccctaacagaactggagctggtaaaa
tgtggaatacagatgtattatgagctcaaagtggtggataaatttcacattccacaagag
gccctggtgcggttcatgtactccctgagtaagggctaccgcaagatcacctaccacaac
tggcggcacggcttcaacgtggggcagaccatgttctccctgctggtgacgggaaagctg
aagcgctacttcacggacctagaggccttggccatggtcactgctgctttctgccatgac
attgaccacagaggcaccaataacctctaccagatgaaatcccagaacccactggccaag
ctccatgggtcctctatcttggaaagacaccacttggagtttggcaaaacactgctcaga
gacgagagcctgaatatctttcaaaacctcaatcgtcgacagcatgagcatgccatccac
atgatggacattgcaatcattgccacagacctcgccctgtatttcaagaagaggacgatg
ttccaaaagatcgtggatcagtctaagacatatgagagtgaacaggagtggacacagtac
atgatgctggagcagacacggaaggaaatcgttatggccatgatgatgaccgcctgtgat
ctctcagccatcaccaaaccctgggaggtgcagagccaggtagctctgctggtggctgct
gaattctgggaacaaggtgacctggagcgcacggtgctgcaacagaatcccattcccatg
atggacagaaacaaagcagatgaactccctaagcttcaagtcggcttcattgactttgtt
tgcaccttcgtctacaaggaattctcccgtttccacgaggagatcaccccaatgttggac
gggatcaccaacaatcgcaaggagtggaaggcgcttgctgatgagtacgatgccaagatg
aaggtgcaggaggagaagaagcagaaacagcagtcggccaagtcagcagccgcaggaaat
cagccggggggaaaccccagcccagggggtgcaactacatccaagtcctgctgcatccag
taa
Homo sapiens (human): 5148
Help
Entry
5148 CDS
T01001
Symbol
PDE6G, PDEG, RP57
Name
(RefSeq) phosphodiesterase 6G
KO
K13759
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04744
Phototransduction
Disease
H00527
Retinitis pigmentosa
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5148 (PDE6G)
09150 Organismal Systems
09157 Sensory system
04744 Phototransduction
5148 (PDE6G)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDE6_gamma
Motif
Other DBs
NCBI-GeneID:
5148
NCBI-ProteinID:
NP_002593
OMIM:
180073
HGNC:
8789
Ensembl:
ENSG00000185527
UniProt:
P18545
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:complement(81650459..81663127)
Genome browser
AA seq
87 aa
AA seq
DB search
MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGL
GTDITVICPWEAFNHLELHELAQYGII
NT seq
264 nt
NT seq
+upstream
nt +downstream
nt
atgaacctggaaccgcccaaggctgagttccggtcagccaccagggtggccgggggacct
gtcacccccaggaaagggccccctaaatttaagcagcgacagaccaggcagttcaagagc
aagcccccaaagaaaggcgttcaagggtttggggacgacatccctggaatggaaggcctg
ggaacagacatcacagtcatctgcccttgggaggccttcaaccacctggagctgcacgag
ctggcccaatatggcatcatctag
Homo sapiens (human): 5158
Help
Entry
5158 CDS
T01001
Symbol
PDE6B, CSNB3, CSNBAD2, GMP-PDEbeta, PDEB, RP40, rd1
Name
(RefSeq) phosphodiesterase 6B
KO
K13756
rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [EC:
3.1.4.35
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04744
Phototransduction
Disease
H00527
Retinitis pigmentosa
H00787
Congenital stationary night blindness
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5158 (PDE6B)
09150 Organismal Systems
09157 Sensory system
04744 Phototransduction
5158 (PDE6B)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
5158 (PDE6B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDEase_I
GAF
GAF_2
GAF_3
HD-CE
DUF6115
Motif
Other DBs
NCBI-GeneID:
5158
NCBI-ProteinID:
NP_000274
OMIM:
180072
HGNC:
8786
Ensembl:
ENSG00000133256
UniProt:
P35913
LinkDB
All DBs
Position
4:625573..670782
Genome browser
AA seq
854 aa
AA seq
DB search
MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL
ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
SGPRTPDGREIVFYKVIDYVLHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC
NGGPAPKSSTCCIL
NT seq
2565 nt
NT seq
+upstream
nt +downstream
nt
atgagcctcagtgaggagcaggcccggagctttctggaccagaaccccgattttgcccgc
cagtactttgggaagaaactgagccctgagaatgtggccgcggcctgcgaggacgggtgc
ccgccggactgcgacagcctccgggacctctgccaggtggaggagagcacggcgctgctg
gagctggtgcaggatatgcaggagagcatcaacatggagcgcgtggtcttcaaggtcctg
cggcgcctctgcaccctcctgcaggccgaccgctgcagcctcttcatgtaccgccagcgc
aacggcgtggccgagctggccaccaggcttttcagcgtgcagccggacagcgtcctggag
gactgcctggtgccccccgactccgagatcgtcttcccactggacatcggggtcgtgggc
cacgtggctcagaccaaaaagatggtgaacgtcgaggacgtggccgagtgccctcacttc
agctcatttgctgacgagctcactgactacaagacaaagaatatgctggccacacccatc
atgaatggcaaagacgtcgtggcggtgatcatggcagtgaacaagctcaacggcccattc
ttcaccagcgaagacgaagatgtgttcttgaagtacctgaattttgccacgttgtacctg
aagatctatcacctgagctacctccacaactgcgagacgcgccgcggccaggtgctgctg
tggtcggccaacaaggtgtttgaggagctgacggacatcgagaggcagttccacaaggcc
ttctacacggtgcgggcctacctcaactgcgagcggtactccgtgggcctcctggacatg
accaaggagaaggaattttttgacgtgtggtctgtgctgatgggagagtcccagccgtac
tcgggcccacgcacgcctgatggccgggaaattgtcttctacaaagtgatcgactacgtc
ctccacggcaaggaggagatcaaggtcattcccacaccctcagccgatcactgggccctg
gccagcggccttccaagctacgtggcagaaagcggctttatttgtaacatcatgaatgct
tccgctgacgaaatgttcaaatttcaggaaggggccctggacgactccgggtggctcatc
aagaatgtgctgtccatgcccatcgtcaacaagaaggaggagattgtgggagtcgccaca
ttttacaacaggaaagacgggaagccctttgacgaacaggacgaggttctcatggagtcc
ctgacacagttcctgggctggtcagtgatgaacaccgacacctacgacaagatgaacaag
ctggagaaccgcaaggacatcgcacaggacatggtcctttaccacgtgaagtgcgacagg
gacgagatccagctcatcctgccaaccagagcgcgcctggggaaggagcctgctgactgc
gatgaggacgagctgggcgaaatcctgaaggaggagctgccagggcccaccacatttgac
atctacgaattccacttctctgacctggagtgcaccgaactggacctggtcaaatgtggc
atccagatgtactacgagctgggcgtggtccgaaagttccagatcccccaggaggtcctg
gtgcggttcctgttctccatcagcaaagggtaccggagaatcacctaccacaactggcgc
cacggcttcaacgtggcccagacgatgttcacgctgctcatgaccggcaaactgaagagc
tactacacggacctggaggccttcgccatggtgacagccggcctgtgccatgacatcgac
caccgcggcaccaacaacctgtaccagatgaagtcccagaaccccttggctaagctccac
ggctcctcgattttggagcggcaccacctggagtttgggaagttcctgctctcggaggag
accctgaacatctaccagaacctgaaccggcggcagcacgagcacgtgatccacctgatg
gacatcgccatcatcgccacggacctggccctgtacttcaagaagagagcgatgtttcag
aagatcgtggatgagtccaagaactaccaggacaagaagagctgggtggagtacctgtcc
ctggagacgacccggaaggagatcgtcatggccatgatgatgacagcctgcgacctgtct
gccatcaccaagccctgggaagtccagagcaaggtcgcacttctcgtggctgctgagttc
tgggagcaaggtgacttggaaaggacagtcttggatcagcagcccattcctatgatggac
cggaacaaggcggccgagctccccaagctgcaagtgggcttcatcgacttcgtgtgcaca
ttcgtgtacaaggagttctctcgtttccacgaagagatcctgcccatgttcgaccgactg
cagaacaataggaaagagtggaaggcgctggctgatgagtatgaggccaaagtgaaggct
ctggaggagaaggaggaggaggagagggtggcagccaagaaagtaggcacagaaatttgc
aatggcggcccagcacccaagtcttcaacctgctgtatcctgtga
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integrated database retrieval system
