Homo sapiens (human): 5170
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Entry
5170 CDS
T01001
Symbol
PDPK1, PDK1, PDPK2, PDPK2P, PRO0461
Name
(RefSeq) 3-phosphoinositide dependent protein kinase 1
KO
K06276
3-phosphoinositide dependent protein kinase-1 [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa03320
PPAR signaling pathway
hsa04068
FoxO signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04140
Autophagy - animal
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04152
AMPK signaling pathway
hsa04210
Apoptosis
hsa04360
Axon guidance
hsa04510
Focal adhesion
hsa04660
T cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04910
Insulin signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa04931
Insulin resistance
hsa04960
Aldosterone-regulated sodium reabsorption
hsa05145
Toxoplasmosis
hsa05205
Proteoglycans in cancer
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05213
Endometrial cancer
hsa05215
Prostate cancer
hsa05223
Non-small cell lung cancer
hsa05231
Choline metabolism in cancer
hsa05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
5170 (PDPK1)
04071 Sphingolipid signaling pathway
5170 (PDPK1)
04151 PI3K-Akt signaling pathway
5170 (PDPK1)
04152 AMPK signaling pathway
5170 (PDPK1)
04150 mTOR signaling pathway
5170 (PDPK1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
5170 (PDPK1)
09150 Organismal Systems
09151 Immune system
04660 T cell receptor signaling pathway
5170 (PDPK1)
04664 Fc epsilon RI signaling pathway
5170 (PDPK1)
09152 Endocrine system
04919 Thyroid hormone signaling pathway
5170 (PDPK1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
5170 (PDPK1)
09156 Nervous system
04722 Neurotrophin signaling pathway
5170 (PDPK1)
09158 Development and regeneration
04360 Axon guidance
5170 (PDPK1)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
5170 (PDPK1)
05208 Chemical carcinogenesis - reactive oxygen species
5170 (PDPK1)
05231 Choline metabolism in cancer
5170 (PDPK1)
09162 Cancer: specific types
05215 Prostate cancer
5170 (PDPK1)
05213 Endometrial cancer
5170 (PDPK1)
05223 Non-small cell lung cancer
5170 (PDPK1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
5170 (PDPK1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5170 (PDPK1)
09167 Endocrine and metabolic disease
04931 Insulin resistance
5170 (PDPK1)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
5170 (PDPK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
5170 (PDPK1)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
5170 (PDPK1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
5170 (PDPK1)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
PDK1 family
5170 (PDPK1)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Acrosomal exocytosis proteins
5170 (PDPK1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PH_3
PK_Tyr_Ser-Thr
Kinase-like
Pkinase_fungal
ABC1
Haspin_kinase
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
5170
NCBI-ProteinID:
NP_002604
OMIM:
605213
HGNC:
8816
Ensembl:
ENSG00000140992
UniProt:
O15530
Structure
PDB
PDBj
LinkDB
All DBs
Position
16:2538021..2603188
Genome browser
AA seq
556 aa
AA seq
DB search
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK
ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN
SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD
FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD
SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE
GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ
EVWRQRYQSHPDAAVQ
NT seq
1671 nt
NT seq
+upstream
nt +downstream
nt
atggccaggaccaccagccagctgtatgacgccgtgcccatccagtccagcgtggtgtta
tgttcctgcccatccccatcaatggtgaggacccagactgagtccagcacgccccctggc
attcctggtggcagcaggcagggccccgccatggacggcactgcagccgagcctcggccc
ggcgccggctccctgcagcatgcccagcctccgccgcagcctcggaagaagcggcctgag
gacttcaagtttgggaaaatccttggggaaggctctttttccacggttgtcctggctcga
gaactggcaacctccagagaatatgcgattaaaattctggagaagcgacatatcataaaa
gagaacaaggtcccctatgtaaccagagagcgggatgtcatgtcgcgcctggatcacccc
ttctttgttaagctttacttcacatttcaggacgacgagaagctgtatttcggccttagt
tatgccaaaaatggagaactacttaaatatattcgcaaaatcggttcattcgatgagacc
tgtacccgattttacacggctgagattgtgtctgctttagagtacttgcacggcaagggc
atcattcacagggaccttaaaccggaaaacattttgttaaatgaagatatgcacatccag
atcacagattttggaacagcaaaagtcttatccccagagagcaaacaagccagggccaac
tcattcgtgggaacagcgcagtacgtttctccagagctgctcacggagaagtccgcctgt
aagagttcagacctttgggctcttggatgcataatataccagcttgtggcaggactccca
ccattccgagctggaaacgagtatcttatatttcagaagatcattaagttggaatatgac
tttccagaaaaattcttccctaaggcaagagacctcgtggagaaacttttggttttagat
gccacaaagcggttaggctgtgaggaaatggaaggatacggacctcttaaagcacacccg
ttcttcgagtccgtcacgtgggagaacctgcaccagcagacgcctccgaagctcaccgct
tacctgccggctatgtcggaagacgacgaggactgctatggcaattatgacaatctcctg
agccagtttggctgcatgcaggtgtcttcgtcctcctcctcacactccctgtcagcctcc
gacacgggcctgccccagaggtcaggcagcaacatagagcagtacattcacgatctggac
tcgaactcctttgaactggacttacagttttccgaagatgagaagaggttgttgttggag
aagcaggctggcggaaacccttggcaccagtttgtagaaaataatttaatactaaagatg
ggcccagtggataagcggaagggtttatttgcaagacgacgacagctgttgctcacagaa
ggaccacatttatattatgtggatcctgtcaacaaagttctgaaaggtgaaattccttgg
tcacaagaacttcgaccagaggccaagaattttaaaactttctttgtccacacgcctaac
aggacgtattatctgatggaccccagcgggaacgcacacaagtggtgcaggaagatccag
gaggtttggaggcagcgataccagagccacccggacgccgctgtgcagtga
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integrated database retrieval system
