KEGG T01001: 5228

Homo sapiens (human): 5228

Entry

5228              CDS       T01001

Symbol

PGF, D12S1900, PGFL, PIGF, PLGF, PlGF-2, SHGC-10760

Name

(RefSeq) placenta growth factor isoform 2 precursor

K16859

placenta growth factor

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04015

Rap1 signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa04518

Integrin signaling

hsa05200

Pathways in cancer

Network

nt06526 MAPK signaling
nt06530 PI3K signaling

Element

N01592

GF-RTK-RAS-ERK signaling pathway

N01656

GF-RTK-PI3K signaling pathway

N01658

GF-RTK-RAS-PI3K signaling pathway

Drug target

Aflibercept:

D09574<JP/US>

Aflibercept beta:

D10819<JP>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    5228 (PGF)
   04014 Ras signaling pathway
    5228 (PGF)
   04015 Rap1 signaling pathway
    5228 (PGF)
   04151 PI3K-Akt signaling pathway
    5228 (PGF)
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    5228 (PGF)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5228 (PGF)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5228 (PGF)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    5228 (PGF)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Growth factors (RTK binding)
   5228 (PGF)

SSDB

Motif

Pfam:

PDGF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

UniProt:

Structure

LinkDB

Position

14:complement(74941830..74955764)

AA seq 149 aa
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVD
VVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVEL
TFSQHVRCECRPLREKMKPERCGDAVPRR

NT seq 450 nt +upstreamnt +downstreamnt
atgccggtcatgaggctgttcccttgcttcctgcagctcctggccgggctggcgctgcct
gctgtgcccccccagcagtgggccttgtctgctgggaacggctcgtcagaggtggaagtg
gtacccttccaggaagtgtggggccgcagctactgccgggcgctggagaggctggtggac
gtcgtgtccgagtaccccagcgaggtggagcacatgttcagcccatcctgtgtctccctg
ctgcgctgcaccggctgctgcggcgatgagaatctgcactgtgtgccggtggagacggcc
aatgtcaccatgcagctcctaaagatccgttctggggaccggccctcctacgtggagctg
acgttctctcagcacgttcgctgcgaatgccggcctctgcgggagaagatgaagccggaa
aggtgcggcgatgctgttccccggaggtaa

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