KEGG   NETWORK: N01656
Entry
N01656                      Network                                
Name
GF-RTK-PI3K signaling pathway
Definition
GF -> RTK -> PI3K -> PIP3 -> AKT
  Expanded
(1950,7039,2069,374,3084,9542,10718,145957,2246,2247,2248,2249,8822,2251,2252,2253,2254,2255,8823,2250,8817,26281,27006,9965,26291,8074,4803,627,4908,4909,3630,3479,3481,5154,5155,56034,80310,1435,4254,2323,7422,7423,5228,7424,2277,3082,284,285,51378,1942,1943,1944,1945,1946) -> (1956,2064,2065,2066,2260,2263,2261,2264,4804,4914,4915,3643,3480,5156,5159,1436,3815,2322,2321,2324,3791,4233,7010,1969) -> ((5290,5291,5293)+(5295,5296,8503)) -> C05981 -> (207,208,10000)
Class
nt06530 PI3K signaling
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
1950  EGF; epidermal growth factor
7039  TGFA; transforming growth factor alpha
2069  EREG; epiregulin
374  AREG; amphiregulin
3084  NRG1; neuregulin 1
9542  NRG2; neuregulin 2
10718  NRG3; neuregulin 3
145957  NRG4; neuregulin 4
2246  FGF1; fibroblast growth factor 1
2247  FGF2; fibroblast growth factor 2
2248  FGF3; fibroblast growth factor 3
2249  FGF4; fibroblast growth factor 4
8822  FGF17; fibroblast growth factor 17
2251  FGF6; fibroblast growth factor 6
2252  FGF7; fibroblast growth factor 7
2253  FGF8; fibroblast growth factor 8
2254  FGF9; fibroblast growth factor 9
2255  FGF10; fibroblast growth factor 10
8823  FGF16; fibroblast growth factor 16
2250  FGF5; fibroblast growth factor 5
8817  FGF18; fibroblast growth factor 18
26281  FGF20; fibroblast growth factor 20
27006  FGF22; fibroblast growth factor 22
9965  FGF19; fibroblast growth factor 19
26291  FGF21; fibroblast growth factor 21
8074  FGF23; fibroblast growth factor 23
4803  NGF; nerve growth factor
627  BDNF; brain derived neurotrophic factor
4908  NTF3; neurotrophin 3
4909  NTF4; neurotrophin 4
3630  INS; insulin
3479  IGF1; insulin like growth factor 1
3481  IGF2; insulin like growth factor 2
5154  PDGFA; platelet derived growth factor subunit A
5155  PDGFB; platelet derived growth factor subunit B
56034  PDGFC; platelet derived growth factor C
80310  PDGFD; platelet derived growth factor D
1435  CSF1; colony stimulating factor 1
4254  KITLG; KIT ligand
2323  FLT3LG; fms related receptor tyrosine kinase 3 ligand
7422  VEGFA; vascular endothelial growth factor A
7423  VEGFB; vascular endothelial growth factor B
5228  PGF; placental growth factor
7424  VEGFC; vascular endothelial growth factor C
2277  VEGFD; vascular endothelial growth factor D
3082  HGF; hepatocyte growth factor
284  ANGPT1; angiopoietin 1
285  ANGPT2; angiopoietin 2
51378  ANGPT4; angiopoietin 4
1942  EFNA1; ephrin A1
1943  EFNA2; ephrin A2
1944  EFNA3; ephrin A3
1945  EFNA4; ephrin A4
1946  EFNA5; ephrin A5
1956  EGFR; epidermal growth factor receptor
2064  ERBB2; erb-b2 receptor tyrosine kinase 2
2065  ERBB3; erb-b2 receptor tyrosine kinase 3
2066  ERBB4; erb-b2 receptor tyrosine kinase 4
2260  FGFR1; fibroblast growth factor receptor 1
2263  FGFR2; fibroblast growth factor receptor 2
2261  FGFR3; fibroblast growth factor receptor 3
2264  FGFR4; fibroblast growth factor receptor 4
4804  NGFR; nerve growth factor receptor
4914  NTRK1; neurotrophic receptor tyrosine kinase 1
4915  NTRK2; neurotrophic receptor tyrosine kinase 2
3643  INSR; insulin receptor
3480  IGF1R; insulin like growth factor 1 receptor
5156  PDGFRA; platelet derived growth factor receptor alpha
5159  PDGFRB; platelet derived growth factor receptor beta
1436  CSF1R; colony stimulating factor 1 receptor
3815  KIT; KIT proto-oncogene, receptor tyrosine kinase
2322  FLT3; fms related receptor tyrosine kinase 3
2321  FLT1; fms related receptor tyrosine kinase 1
2324  FLT4; fms related receptor tyrosine kinase 4
3791  KDR; kinase insert domain receptor
4233  MET; MET proto-oncogene, receptor tyrosine kinase
7010  TEK; TEK receptor tyrosine kinase
1969  EPHA2; EPH receptor A2
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22435804
  Authors
Berridge MJ
  Title
Calcium signalling remodelling and disease.
  Journal
Biochem Soc Trans 40:297-309 (2012)
DOI:10.1042/BST20110766
Reference
PMID:31443495
  Authors
Buchanan CM, Lee KL, Shepherd PR
  Title
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors.
  Journal
Biomolecules 9:biom9090402 (2019)
DOI:10.3390/biom9090402
LinkDB

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