Homo sapiens (human): 5321
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Entry
5321 CDS
T01001
Symbol
PLA2G4A, GURDP, PLA2G4, cPLA2, cPLA2-alpha
Name
(RefSeq) phospholipase A2 group IVA
KO
K16342
cytosolic phospholipase A2 [EC:
3.1.1.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00564
Glycerophospholipid metabolism
hsa00565
Ether lipid metabolism
hsa00590
Arachidonic acid metabolism
hsa00591
Linoleic acid metabolism
hsa00592
alpha-Linolenic acid metabolism
hsa01100
Metabolic pathways
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04217
Necroptosis
hsa04270
Vascular smooth muscle contraction
hsa04370
VEGF signaling pathway
hsa04611
Platelet activation
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa04724
Glutamatergic synapse
hsa04726
Serotonergic synapse
hsa04730
Long-term depression
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04912
GnRH signaling pathway
hsa04913
Ovarian steroidogenesis
hsa04921
Oxytocin signaling pathway
hsa05231
Choline metabolism in cancer
Network
nt06544
Neuroactive ligand signaling
Element
N01900
Serotonin-HTR2-GNAQ/11 signaling pathway
Disease
H02504
Gastrointestinal ulceration, recurrent, with dysfunctional platelets
Drug target
Ecopladib:
D03938
Efipladib:
D06674
Giripladib:
D06600
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00564 Glycerophospholipid metabolism
5321 (PLA2G4A)
00565 Ether lipid metabolism
5321 (PLA2G4A)
00590 Arachidonic acid metabolism
5321 (PLA2G4A)
00591 Linoleic acid metabolism
5321 (PLA2G4A)
00592 alpha-Linolenic acid metabolism
5321 (PLA2G4A)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
5321 (PLA2G4A)
04072 Phospholipase D signaling pathway
5321 (PLA2G4A)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
5321 (PLA2G4A)
04664 Fc epsilon RI signaling pathway
5321 (PLA2G4A)
04666 Fc gamma R-mediated phagocytosis
5321 (PLA2G4A)
09152 Endocrine system
04913 Ovarian steroidogenesis
5321 (PLA2G4A)
04921 Oxytocin signaling pathway
5321 (PLA2G4A)
09156 Nervous system
04724 Glutamatergic synapse
5321 (PLA2G4A)
04726 Serotonergic synapse
5321 (PLA2G4A)
04730 Long-term depression
5321 (PLA2G4A)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
5321 (PLA2G4A)
09160 Human Diseases
09161 Cancer: overview
05231 Choline metabolism in cancer
5321 (PLA2G4A)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.1.4 phospholipase A2
5321 (PLA2G4A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PLA2_B
C2
cPLA2_C2
Motif
Other DBs
NCBI-GeneID:
5321
NCBI-ProteinID:
NP_077734
OMIM:
600522
HGNC:
9035
Ensembl:
ENSG00000116711
UniProt:
P47712
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:186828949..186988981
Genome browser
AA seq
749 aa
AA seq
DB search
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
NT seq
2250 nt
NT seq
+upstream
nt +downstream
nt
atgtcatttatagatccttaccagcacattatagtggagcaccagtattcccacaagttt
acggtagtggtgttacgtgccaccaaagtgacaaagggggcctttggtgacatgcttgat
actccagatccctatgtggaactttttatctctacaacccctgacagcaggaagagaaca
agacatttcaataatgacataaaccctgtgtggaatgagacctttgaatttattttggat
cctaatcaggaaaatgttttggagattacgttaatggatgccaattatgtcatggatgaa
actctagggacagcaacatttactgtatcttctatgaaggtgggagaaaagaaagaagtt
ccttttattttcaaccaagtcactgaaatggttctagaaatgtctcttgaagtttgctca
tgcccagacctacgatttagtatggctctgtgtgatcaggagaagactttcagacaacag
agaaaagaacacataagggagagcatgaagaaactcttgggtccaaagaatagtgaagga
ttgcattctgcacgtgatgtgcctgtggtagccatattgggttcaggtgggggtttccga
gccatggtgggattctctggtgtgatgaaggcattatacgaatcaggaattctggattgt
gctacctacgttgctggtctttctggctccacctggtatatgtcaaccttgtattctcac
cctgattttccagagaaagggccagaggagattaatgaagaactaatgaaaaatgttagc
cacaatccccttttacttctcacaccacagaaagttaaaagatatgttgagtctttatgg
aagaagaaaagctctggacaacctgtcacctttactgatatctttgggatgttaatagga
gaaacactaattcataatagaatgaatactactctgagcagtttgaaggaaaaagttaat
actgcacaatgccctttacctcttttcacctgtcttcatgtcaaacctgacgtttcagag
ctgatgtttgcagattgggttgaatttagtccatacgaaattggcatggctaaatatggt
acttttatggctcccgacttatttggaagcaaattttttatgggaacagtcgttaagaag
tatgaagaaaaccccttgcatttcttaatgggtgtctggggcagtgccttttccatattg
ttcaacagagttttgggcgtttctggttcacaaagcagaggctccacaatggaggaagaa
ttagaaaatattaccacaaagcatattgtgagtaatgatagctcggacagtgatgatgaa
tcacacgaacccaaaggcactgaaaatgaagatgctggaagtgactatcaaagtgataat
caagcaagttggattcatcgtatgataatggccttggtgagtgattcagctttattcaat
accagagaaggacgtgctgggaaggtacacaacttcatgctgggcttgaatctcaataca
tcttatccactgtctcctttgagtgactttgccacacaggactcctttgatgatgatgaa
ctggatgcagctgtagcagatcctgatgaatttgagcgaatatatgagcctctggatgtc
aaaagtaaaaagattcatgtagtggacagtgggctcacatttaacctgccgtatcccttg
atactgagacctcagagaggggttgatctcataatctcctttgacttttctgcaaggcca
agtgactctagtcctccgttcaaggaacttctacttgcagaaaagtgggctaaaatgaac
aagctcccctttccaaagattgatccttatgtgtttgatcgggaagggctgaaggagtgc
tatgtctttaaacccaagaatcctgatatggagaaagattgcccaaccatcatccacttt
gttctggccaacatcaacttcagaaagtacagggctccaggtgttccaagggaaactgag
gaagagaaagaaatcgctgactttgatatttttgatgacccagaatcaccattttcaacc
ttcaattttcaatatccaaatcaagcattcaaaagactacatgatcttatgcacttcaat
actctgaacaacattgatgtgataaaagaagccatggttgaaagcattgaatatagaaga
cagaatccatctcgttgctctgtttcccttagtaatgttgaggcaagaagatttttcaac
aaggagtttctaagtaaacccaaagcatag
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