KEGG   NETWORK: N01900
Entry
N01900                      Network                                
Name
Serotonin-HTR2-GNAQ/11 signaling pathway
Definition
Serotonin -> HTR2 -> (GNAQ,GNA11) -> (PLCB,PLA2G4)
  Expanded
C00780 -> (3356,3357,3358) -> (2776,2767) -> ((23236,5330,5331,5332),(5321,100137049,8605,283748,123745,255189))
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04726  Serotonergic synapse
hsa04082  Neuroactive ligand signaling
Gene
3356  HTR2A; 5-hydroxytryptamine receptor 2A
3357  HTR2B; 5-hydroxytryptamine receptor 2B
3358  HTR2C; 5-hydroxytryptamine receptor 2C
2776  GNAQ; G protein subunit alpha q
2767  GNA11; G protein subunit alpha 11
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5321  PLA2G4A; phospholipase A2 group IVA
100137049  PLA2G4B; phospholipase A2 group IVB
8605  PLA2G4C; phospholipase A2 group IVC
283748  PLA2G4D; phospholipase A2 group IVD
123745  PLA2G4E; phospholipase A2 group IVE
255189  PLA2G4F; phospholipase A2 group IVF
Metabolite
C00780  Serotonin
Reference
  Authors
Berumen LC, Rodriguez A, Miledi R, Garcia-Alcocer G
  Title
Serotonin receptors in hippocampus.
  Journal
ScientificWorldJournal 2012:823493 (2012)
DOI:10.1100/2012/823493
Reference
  Authors
Pourhamzeh M, Moravej FG, Arabi M, Shahriari E, Mehrabi S, Ward R, Ahadi R, Joghataei MT
  Title
The Roles of Serotonin in Neuropsychiatric Disorders.
  Journal
Cell Mol Neurobiol 42:1671-1692 (2022)
DOI:10.1007/s10571-021-01064-9
Reference
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
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