KEGG   Homo sapiens (human): 5361
Entry
5361              CDS       T01001                                 
Symbol
PLXNA1, DWOPNED, NOV, NOVP, PLEXIN-A1, PLXN1
Name
(RefSeq) plexin A1
  KO
K06820  plexin A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
Network
nt06541  Cytoskeleton in neurons
  Element
N01835  SEMA3-CRMP2/MAPT axon guidance signaling
Disease
H02688  Dworschak-Punetha neurodevelopmental syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    5361 (PLXNA1)
SSDB
Motif
Pfam: Plexin_cytopl TIG Plexin_RBD TIG_2 Sema TIG_plexin PSI PSI_PlexinA-B
Other DBs
NCBI-GeneID: 5361
NCBI-ProteinID: NP_115618
OMIM: 601055
HGNC: 9099
Ensembl: ENSG00000114554
UniProt: Q9UIW2
Structure
LinkDB
Position
3:126983115..127037389
AA seq 1896 aa
MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQT
GEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGSTDNVNKLLLL
DYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ
GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFP
AFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVDDPKFYSYVEFPI
GCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF
TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVT
IEGTPLFVDKDDGLTAVAAYDYRGRTVVFAGTRSGRIRKILVDLSNPGGRPALAYESVVA
QEGSPILRDLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCELCLGSRDPHCGWCVLHSI
CSRRDACERADEPQRFAADLLQCVQLTVQPRNVSVTMSQVPLVLQAWNVPDLSAGVNCSF
EDFTESESVLEDGRIHCRSPSAREVAPITRGQGDQRVVKLYLKSKETGKKFASVDFVFYN
CSVHQSCLSCVNGSFPCHWCKYRHVCTHNVADCAFLEGRVNVSEDCPQILPSTQIYVPVG
VVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDVS
DLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRESCGLCLKADPRFECGWCVAERRCSLR
HHCAADTPASWMHARHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGV
RVGKVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVT
PTFYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSVGGRPCSFSWRNSREIRCLTPPGQS
PGSAPIIININRAQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPR
IRAKYGGIERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPDELGFVMDNVRSLLVLN
STSFLYYPDPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPCTLT
VSETQLLCEAPNLTGQHKVTVRAGGFEFSPGTLQVYSDSLLTLPAIVGIGGGGGLLLLVI
VAVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIP
FLDYRTYAMRVLFPGIEDHPVLKEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRS
FSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKM
LTNWFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDY
KTLTLNCVNPENENAPEVPVKGLDCDTVTQAKEKLLDAAYKGVPYSQRPKAADMDLEWRQ
GRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSL
SRYESMLRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDRGSKMVSEIYL
TRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDADVRHTW
KSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKL
LYAKDIPNYKSWVERYYADIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYIT
KYKDEILAALEKDEQARRQRLRSKLEQVVDTMALSS
NT seq 5691 nt   +upstreamnt  +downstreamnt
atgccgctgccaccgcggagcctgcaggtgctcctgctgctgctgctgttgctgctgctg
ctgccgggcatgtgggctgaggcaggcttgcccagggcaggcgggggttcacagcccccc
ttccgcaccttctcggccagcgactggggcctcacccacctagtggtgcatgagcagaca
ggcgaggtgtatgtgggcgcagtgaaccgcatctataagctgtcggggaacctgacactg
ctgcgggcccacgtcacgggccctgtggaggacaacgagaagtgctacccgccgcccagc
gtgcagtcctgcccccacggcctgggcagtactgacaacgtcaacaagctgctgctgctg
gactatgccgctaaccgcctgctggcctgtggcagcgcctcccagggcatctgccagttc
ctgcgtctggacgatctcttcaaactgggtgagccacaccaccgtaaggagcactacctg
tccagcgtgcaggaggcaggcagcatggcgggcgtgctcattgccgggccaccgggccag
ggccaggccaagctcttcgtgggcacacccatcgatggcaagtccgagtacttccccaca
ctgtccagccgtcggctcatggccaacgaggaggatgccgacatgttcggcttcgtgtac
caggatgagtttgtgtcatcacagctcaagatcccttcggacacgctgtccaagttcccg
gcctttgacatctactatgtgtacagcttccgcagcgagcagtttgtctactacctcacg
ctgcagctagacacacagctgacctcgcctgatgccgccggcgagcacttcttcacgtcc
aagatcgtgcggctctgtgtggacgaccccaaattctactcgtacgttgagttccccatt
ggctgcgagcaggcgggtgtggagtaccgcctggtgcaggatgcctacctgagccggccc
ggccgtgccctggcccaccagctgggcctggctgaggacgaggacgtgctgttcactgtg
ttcgcccagggccagaagaaccgcgtgaagccaccaaaggagtcagcactgtgcctgttc
acgctcagggccatcaaggagaagattaaggagcgcatccagtcctgctaccgtggtgag
ggcaagctctccctgccgtggctgctcaacaaggagctgggctgcatcaactcgcccctg
cagatcgatgacgacttctgcgggcaggacttcaaccagcccctggggggcacagtcacc
attgaggggacgcccctgttcgtggacaaggatgatggcctgaccgccgtggctgcctat
gactatcggggccgcactgtggtattcgccggcacgcgaagtggccgcatccgcaagatc
ctggtggacctctcaaaccccggtggccggcctgccctggcctacgagagcgtcgtggcc
caggagggcagccccatcctgcgagacctcgtcctcagccccaaccaccagtacctctac
gccatgaccgagaagcaggtgacgcgggtgcctgtggagagctgtgtgcagtacacgtcc
tgtgagctgtgtctggggtcacgggacccccactgtggctggtgtgtcctgcacagcatc
tgctcgcggcgggacgcctgtgagcgagcagacgagccccagcgctttgctgcggacctg
ctgcagtgtgtgcagctgactgtgcagccccgcaatgtgtctgtcaccatgtcccaggtc
ccacttgtgctgcaggcctggaacgtgcctgacctctcagctggcgtcaactgctccttc
gaggacttcacggaatctgagagcgtcctggaggatggccggatccactgccgctcaccc
tccgcccgggaggtggcgcccatcacgcggggccagggagaccagcgggtggtgaaactc
tacctaaagtccaaggagacagggaagaagtttgcgtctgtggacttcgtcttctacaac
tgcagcgtccaccagtcctgcctgtcctgtgtcaacggctcctttccctgccactggtgc
aaataccgccacgtgtgcacacacaacgtggctgactgcgccttcctggagggccgtgtc
aacgtgtctgaggactgcccacagatcctgccctccacgcagatctacgtgccagtggga
gtggtaaaacccatcaccctggccgcacggaacctgccacagccacagtcaggccagcgt
ggatatgagtgcctcttccacatcccgggcagcccggcccgtgtcaccgccctgcgcttc
aacagctccagcctgcagtgccagaattcctcgtactcctacgaggggaacgatgtcagc
gacctgccagtgaacctgtcagtcgtgtggaacggcaactttgtcattgacaacccacag
aacatccaggcgcacctctacaagtgcccggccctgcgcgagagctgcggcctctgcctc
aaggccgacccgcgcttcgagtgcggatggtgcgtggccgagcgccgctgctccctgcga
caccactgcgctgccgacacacctgcatcgtggatgcacgcgcgtcacggcagcagtcgc
tgcaccgaccccaagatcctcaagctgtcccccgagacgggcccgaggcagggcggcacg
cggctcactatcacaggcgagaacctgggcctgcgattcgaagacgtgcgtctgggcgtg
cgcgtgggcaaggtgctgtgcagccctgtggagagcgagtacatcagtgcggagcagatc
gtctgtgagatcggggacgccagctccgtgcgtgcccatgacgccctggtggaggtgtgt
gtgcgggactgctcaccacactaccgcgccctgtcacccaagcgcttcaccttcgtgaca
ccaaccttctaccgtgtgagcccctcccgtgggcctctgtcagggggcacctggattggc
atcgagggaagccacctgaacgcaggcagtgatgtggctgtgtcggtcggtggccggccc
tgctccttctcctggaggaactcccgtgagatccggtgcctgacaccccccgggcagagc
cctggcagcgctcccatcatcatcaacatcaaccgcgcccagctcaccaaccctgaggtg
aagtacaactacaccgaggaccccaccatcctgaggatcgaccccgagtggagcatcaac
agcggtgggaccctcctgacggtcacaggcaccaacctggccactgtccgtgaaccccga
atccgggccaagtatggaggcattgagagggagaacggctgcctggtgtacaatgacacc
accatggtatgccgcgccccgtctgtggccaaccctgtgcgcagcccaccagagctgggg
gagcggccggatgagctgggcttcgtcatggacaacgtgcgctccctgcttgtgctcaac
tccacctccttcctctactaccctgaccccgtactggagccactcagccccactggcctg
ctggagctgaagcccagctccccactcatcctcaagggccggaacctcttgccacctgca
cccggcaactcccgactcaactacacggtgctcatcggctccacaccctgtaccctcacc
gtgtcggagacgcaactgctgtgcgaggcgcccaacctcactgggcagcacaaggtcacg
gtgcgggcaggtggcttcgagttctcgccagggacactgcaggtgtactcggacagcctg
ctgacgctgcctgccattgtgggcattggcggaggcgggggtctcctgctgctggtcatc
gtggctgtgctcatcgcctacaagcgcaagtcacgagatgctgaccgcacactcaagcgg
ctgcagctccagatggacaacctggagtcccgcgtggccctcgaatgcaaggaagccttt
gcagagctgcagacagacatccacgagctgaccaatgacctggacggtgccggcatcccc
ttccttgactaccggacatatgccatgcgggtgctctttcctgggatcgaggaccaccct
gtgctcaaggagatggaggtgcaggccaatgtggagaagtcgctgacactgttcgggcag
ctgctgaccaagaagcacttcctgctgaccttcatccgcacgctggaggcacagcgcagc
ttctccatgcgcgaccgcgggaatgtggcctcgctcatcatgacggccctgcagggcgag
atggaatacgccacaggcgtgctcaagcagctgctttccgacctcatcgagaagaacctg
gagagcaagaaccaccccaagctgctactgcgccggactgagtcggtggcagagaagatg
ctaactaactggttcaccttcctcttgtataagttcctcaaggagtgcgctggggagccg
ctgttcatgctgtactgcgccatcaagcagcagatggagaagggccccattgacgccatc
acgggtgaggcacgctactccctgagtgaggacaagctcatccggcagcagattgactac
aagacactgaccctgaactgtgtgaaccctgagaatgagaatgcacctgaggtgccggtg
aaggggctggactgtgacacggtcacccaggccaaggagaagctgctggacgctgcctac
aagggcgtgccctactcccagcggcccaaggccgcggacatggacctggagtggcgccag
ggccgcatggcgcgcatcatcctgcaggacgaggacgtcaccaccaagattgacaacgat
tggaagaggctgaacacactggctcactaccaggtgacagacgggtcctcggtggcactg
gtgcccaagcagacgtccgcctacaacatctccaactcctccaccttcaccaagtccctc
agcagatacgagagcatgctgcgcacggccagcagccccgacagcctgcgctcgcgcacg
cccatgatcacgcccgacctggagagcggcaccaagctgtggcacctggtgaagaaccac
gaccacctggaccagcgtgagggtgaccgcggcagcaagatggtctcggagatctacttg
acacggctactggccaccaagggcacactgcagaagtttgtggacgacctgtttgagacc
atcttcagcacggcacaccggggctcagccctgccgctggccatcaagtacatgttcgac
ttcctggatgagcaggccgacaagcaccagatccacgatgctgacgtgcgccacacctgg
aagagcaactgcctgcccctgcgcttctgggtgaacgtgatcaagaacccacagtttgtg
ttcgacattcacaagaacagcatcacggacgcctgcttgtcggtggtggcccagaccttc
atggactcctgctccacctctgagcacaagctgggcaaggactcaccctccaacaagctg
ctctacgccaaggacatccccaactacaagagctgggtggagaggtactatgcagacatc
gccaagatgccagccatcagcgaccaggacatgagtgcgtatctggctgagcagtcccgc
ctgcacctgagccagttcaacagcatgagcgccttgcacgagatctactcctacatcacc
aagtacaaggatgagatcctggcagccctggagaaggatgagcaggcgcggcggcagcgg
ctgcggagcaagctggagcaggtggtggacacgatggccctgagcagctga

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