KEGG   NETWORK: N01835
Entry
N01835                      Network                                
Name
SEMA3-CRMP2/MAPT axon guidance signaling
Definition
SEMA3A -> PLXNA1+NRP1 -> FYN,FES,FER -> (CDK5+CDK5R1) -> CRMP1/2,MAPT == (TUBA+TUBB)
  Expanded
10371 -> 5361+8829 -> 2534,2242,2241 -> (1020+8851) -> 1400,1808,4137 == ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06541 Cytoskeleton in neurons
Type
Reference
Gene
10371  SEMA3A; semaphorin 3A
5361  PLXNA1; plexin A1
8829  NRP1; neuropilin 1
2534  FYN; FYN proto-oncogene, Src family tyrosine kinase
2242  FES; FES proto-oncogene, tyrosine kinase
2241  FER; FER tyrosine kinase
1020  CDK5; cyclin dependent kinase 5
8851  CDK5R1; cyclin dependent kinase 5 regulatory subunit 1
1400  CRMP1; collapsin response mediator protein 1
1808  DPYSL2; dihydropyrimidinase like 2
4137  MAPT; microtubule associated protein tau
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Reference
PMID:18580951
  Authors
Neufeld G, Kessler O
  Title
The semaphorins: versatile regulators of tumour progression and tumour angiogenesis.
  Journal
Nat Rev Cancer 8:632-45 (2008)
DOI:10.1038/nrc2404
Reference
PMID:34924953
  Authors
Sanchez-Huertas C, Herrera E
  Title
With the Permission of Microtubules: An Updated Overview on Microtubule Function During Axon Pathfinding.
  Journal
Front Mol Neurosci 14:759404 (2021)
DOI:10.3389/fnmol.2021.759404
Reference
PMID:12372285
  Authors
Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y
  Title
Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.
  Journal
Neuron 35:907-20 (2002)
DOI:10.1016/s0896-6273(02)00857-7
LinkDB

DBGET integrated database retrieval system