Homo sapiens (human): 5431 Help Entry 5431              CDS       T01001                                  Symbol POLR2B, POL2RB, RPB2, hRPB140 Name (RefSeq) RNA polymerase II subunit B   KO K03010   DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6] Organism hsa  Homo sapiens (human) Pathway hsa03020   RNA polymerase hsa03420   Nucleotide excision repair hsa05016   Huntington disease Network nt06502  Nucleotide excision repair   Element N01430   Transcription-coupled NER Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09121 Transcription    03020 RNA polymerase     5431 (POLR2B)   09124 Replication and repair    03420 Nucleotide excision repair     5431 (POLR2B)  09160 Human Diseases   09164 Neurodegenerative disease    05016 Huntington disease     5431 (POLR2B)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03021 Transcription machinery [BR:hsa03021]     5431 (POLR2B)    03400 DNA repair and recombination proteins [BR:hsa03400]     5431 (POLR2B) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.7  Nucleotidyltransferases     2.7.7.6  DNA-directed RNA polymerase      5431 (POLR2B) Transcription machinery [BR:hsa03021]  Eukaryotic type   RNA polymerase II system    RNA polymerase II     Core subunits      5431 (POLR2B) DNA repair and recombination proteins [BR:hsa03400]  Eukaryotic type   SSBR (single strand breaks repair)    NER (nucleotide excision repair)     TCR (transcription coupled repair) factors      DNA-directed RNA polymerase II complex       5431 (POLR2B) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RNA_pol_Rpb2_6 RNA_pol_Rpb2_1 RNA_pol_Rpb2_2 RNA_pol_Rpb2_7 RNA_pol_Rpb2_4 RNA_pol_Rpb2_3 RNA_pol_Rpb2_5 DUF5817 Motif Other DBs NCBI-GeneID:  5431 NCBI-ProteinID:  NP_000929 OMIM:  180661 HGNC:  9188 Ensembl:  ENSG00000047315 UniProt:  P30876 B4DH29 Structure PDBPDBj LinkDB All DBs Position 4:56978896..57031158 Genome browser AA seq 1174 aa AA seqDB search MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV NT seq 3525 nt NT seq  +upstreamnt  +downstreamnt atgtacgacgcggatgaggatatgcaatatgatgaggatgatgatgaaatcaccccggat ttgtggcaagaagcatgctggattgtaatcagttcctattttgacgagaaaggcttggtt agacaacagctggattcttttgatgagtttattcagatgtctgttcaaagaattgtggaa gacgctcctcctatagacctacaggctgaagctcagcatgctagtggagaagttgaagaa ccgccacgatatttgctgaagtttgaacaaatttatctttccaagcctacccattgggaa agagatggtgctccttcaccaatgatgcccaatgaagctagattaaggaatctcacgtat tctgctccgctttatgttgatataacaaaaacagtcattaaagaaggtgaagaacaactt cagactcagcatcagaaaacttttataggaaaaattccaattatgttgcggtcaacttac tgccttttgaatggcttgacagatcgtgatctttgtgagttaaatgaatgccctttggat cctggtggctatttcattattaatggatcagaaaaggttctgattgcccaagagaaaatg gcaacaaacacagtttatgtgtttgccaaaaaggattctaaatatgcctacacaggagag tgtagatcatgtcttgagaattcttcccgacccaccagtactatatgggttagcatgctg gcaagaggaggacagggtgccaagaagagtgctattggtcagcgcattgtggcaactcta ccatatatcaagcaagaagttcccatcattattgtgttcagagcattaggttttgtgtcc gacagagatattttagaacatattatttatgattttgaagatccagagatgatggaaatg gttaaaccttctctcgatgaagcttttgtcatccaagaacagaatgttgcactaaatttc attggttcaagaggagcaaagcctggtgttactaaagagaaaagaattaaatatgcaaag gaagttttacaaaaagaaatgctccctcatgttggtgtcagtgatttttgtgagaccaaa aaagcctatttcttgggatacatggttcataggttacttctggcagctttgggtagaaga gaactagatgacagagatcactatggaaacaagagattggatcttgctgggccgctgctt gcattcttatttagaggtatgtttaagaatttgcttaaagaagtgcggatctatgcacag aaatttattgatcgaggaaaggattttaacttggagttggcaattaaaacacggatcata tctgatggcctaaaatactctttagctactggaaactggggtgatcaaaagaaagctcat caagccagagctggagtatctcaggtgttaaaccgcctgacttttgcgtctactctttct cacctgcgtcgtttaaattctcctattggtagagacggcaagctagcaaaaccaagacag ttgcataatacgttgtggggaatggtgtgtcctgccgagaccccagagggccatgctgta ggacttgtgaagaatttagccttgatggcgtatatttcagttggatctcaaccatctcca attctggaatttttagaagaatggagtatggaaaatttagaagaaatttctcctgcagct attgctgatgcaaccaagatttttgttaatggctgctgggttggaatacataaagatccc gaacaacttatgaacaccctaaggaaattgagacgtcagatggacatcattgtgtctgaa gtttctatgatcagagatattcgagagagggagattcggatctatacggatgcaggccgt atttgtagaccacttctgattgtggaaaaacaaaagctacttttgaagaagaggcatatt gaccaattgaaagagagagaatataacaactatagttggcaggatcttgtggccagtggg gtagtggagtatattgataccctggaagaagaaacagtgatgcttgcaatgactccagat gatttacaggagaaagaagtagcttattgttccacatatacacactgtgagattcatccc tcaatgatccttggtgtctgtgcatctattattccctttcctgatcataaccagtcccct agaaacacataccagtctgctatgggtaagcaggctatgggagtttacatcaccaacttc catgttcgcatggacacattggcccatgttctctattatcctcaaaagccacttgtgact acacggtctatggaatatctacgatttagagagctgccagcaggcatcaactcaattgtg gccattgcatcatacactggatataatcaggaagactctgttatcatgaatcgttcagct gtagaccgcggcttcttcaggtctgttttctatcgctcatacaaagaacaggagtctaaa aaaggatttgatcaagaagaagtttttgagaagcctacacgtgaaacatgccagggcatg aggcatgccatttacgacaagctggatgatgatggtttgatagctccaggggttcgtgta tcaggagatgatgttattataggcaaaacagtcaccttgcctgaaaatgaagatgaattg gagagcaccaatagacgctataccaagagagactgtagcacttttctcagaactagcgag acgggcattgtggatcaggttatggtaactctcaatcaggaaggatataaattttgtaaa ataagggtacgctctgttaggattccacagattggagacaaatttgctagtcgacatggt caaaagggtacttgtggtattcagtatagacaagaggatatgcctttcacctgtgaaggt atcacccctgatatcatcatcaatccccatgccatcccctctcgtatgactattggtcac ttaattgaatgccttcaagggaaggtatcggctaacaagggtgaaattggtgatgccact ccatttaatgatgctgttaacgtgcagaagatttctaatcttttatctgattatggctat catctcagaggaaatgaggtcctgtacaatgggttcactggtcgaaaaatcacatcacaa atatttattggccccacttattaccagcgtttgaagcatatggtggatgataagattcac tctcgtgctaggggacctattcagatcctcaatagacagcccatggagggtagatctcgt gatggtggcctgcgttttggagaaatggaacgagattgtcagattgcccatggagcagcc cagtttttaagggaaagattgtttgaggcatcagatccatatcaggttcatgtttgcaat ctttgtggaataatggcgattgccaacaccaggacccatacatatgaatgcaggggctgc cgcaataaaacccagatttctttggtgcgaatgccttacgcatgcaaactattgtttcag gaacttatgtctatgagtattgcaccgcgaatgatgagtgtttag

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