KEGG   NETWORK: N01430
Entry
N01430                      Network                                
Name
Transcription-coupled NER
Definition
(POLR2+UVSSA) == (ERCC6+ERCC8+CRL4) -> (POLR2+UVSSA+ERCC6+ERCC8+CRL4) == (ERCC3+ERCC2) == (GTF2H) == (CAK)
  Expanded
(5430+5431+5432+5433+5434+5435+5436+5437+5438+5439+246721+548644+5440+5441+81488+57654) == (2074+1161+9978+8451+1642) -> (5430+5431+5432+5433+5434+5435+5436+5437+5438+5439+246721+548644+5440+5441+81488+57654+2074+1161+9978+8451+1642) == (2071+2068) == (2965+2966+2967+2968+404672) == (1022+902+4331)
Class
nt06502 Nucleotide excision repair
Type
Reference
Pathway
hsa03420  Nucleotide excision repair
Gene
5430  POLR2A; RNA polymerase II subunit A
5431  POLR2B; RNA polymerase II subunit B
5432  POLR2C; RNA polymerase II subunit C
5433  POLR2D; RNA polymerase II subunit D
5434  POLR2E; RNA polymerase II, I and III subunit E
5435  POLR2F; RNA polymerase II, I and III subunit F
5436  POLR2G; RNA polymerase II subunit G
5437  POLR2H; RNA polymerase II, I and III subunit H
5438  POLR2I; RNA polymerase II subunit I
5439  POLR2J; RNA polymerase II subunit J
246721  POLR2J2; RNA polymerase II subunit J2
548644  POLR2J3; RNA polymerase II subunit J3
5440  POLR2K; RNA polymerase II, I and III subunit K
5441  POLR2L; RNA polymerase II, I and III subunit L
81488  POLR2M; RNA polymerase II subunit M
57654  UVSSA; UV stimulated scaffold protein A
2074  ERCC6; ERCC excision repair 6, chromatin remodeling factor
1161  ERCC8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit
9978  RBX1; ring-box 1
8451  CUL4A; cullin 4A
1642  DDB1; damage specific DNA binding protein 1
2071  ERCC3; ERCC excision repair 3, TFIIH core complex helicase subunit
2068  ERCC2; ERCC excision repair 2, TFIIH core complex helicase subunit
2965  GTF2H1; general transcription factor IIH subunit 1
2966  GTF2H2; general transcription factor IIH subunit 2
2967  GTF2H3; general transcription factor IIH subunit 3
2968  GTF2H4; general transcription factor IIH subunit 4
404672  GTF2H5; general transcription factor IIH subunit 5
1022  CDK7; cyclin dependent kinase 7
902  CCNH; cyclin H
4331  MNAT1; MNAT1 component of CDK activating kinase
Reference
  Authors
Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T
  Title
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
  Journal
Cell 180:1228-1244.e24 (2020)
DOI:10.1016/j.cell.2020.02.010
Reference
  Authors
Krasikova Y, Rechkunova N, Lavrik O
  Title
Nucleotide Excision Repair: From Molecular Defects to Neurological Abnormalities.
  Journal
Int J Mol Sci 22:6220 (2021)
DOI:10.3390/ijms22126220
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