KEGG   Homo sapiens (human): 54361
Entry
54361             CDS       T01001                                 
Symbol
WNT4, SERKAL, WNT-4
Name
(RefSeq) Wnt family member 4
  KO
K00408  wingless-type MMTV integration site family, member 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04150  mTOR signaling pathway
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04390  Hippo signaling pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04916  Melanogenesis
hsa04919  Thyroid hormone signaling pathway
hsa04934  Cushing syndrome
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06215  WNT signaling (cancer)
nt06217  HH signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06269  Basal cell carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06505  WNT signaling
  Element
N00010  Mutation-inactivated PTCH1 to Hedgehog signaling pathway
N00017  Mutation-activated SMO to Hedgehog signaling pathway
N00056  Wnt signaling pathway
N00059  FZD7-overexpression to Wnt signaling pathway
N00060  LRP6-overexpression to Wnt signaling pathway
N01362  Nuclear-initiated progesterone signaling pathway
N01442  Wnt signaling modulation, Wnt inhibitor
N01443  Wnt signaling modulation, Wnt acylation
Disease
H00600  Mullerian agenesis
H02317  SERKAL syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    54361 (WNT4)
   04390 Hippo signaling pathway
    54361 (WNT4)
   04150 mTOR signaling pathway
    54361 (WNT4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    54361 (WNT4)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    54361 (WNT4)
   04916 Melanogenesis
    54361 (WNT4)
  09158 Development and regeneration
   04360 Axon guidance
    54361 (WNT4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    54361 (WNT4)
   05205 Proteoglycans in cancer
    54361 (WNT4)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    54361 (WNT4)
   05226 Gastric cancer
    54361 (WNT4)
   05217 Basal cell carcinoma
    54361 (WNT4)
   05224 Breast cancer
    54361 (WNT4)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    54361 (WNT4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    54361 (WNT4)
   05022 Pathways of neurodegeneration - multiple diseases
    54361 (WNT4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    54361 (WNT4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    54361 (WNT4)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Morphogens
   54361 (WNT4)
SSDB
Motif
Pfam: wnt DUF6973
Other DBs
NCBI-GeneID: 54361
NCBI-ProteinID: NP_110388
OMIM: 603490
HGNC: 12783
Ensembl: ENSG00000162552
UniProt: P56705
LinkDB
Position
1:complement(22117313..22143097)
AA seq 351 aa
MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRN
LEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGV
AFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGAS
SSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDG
ATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTS
KAIDGCELLCCGRGFHTAQVELAERCSCKFHWCCFVKCRQCQRLVELHTCR
NT seq 1056 nt   +upstreamnt  +downstreamnt
atgagtccccgctcgtgcctgcgttcgctgcgcctcctcgtcttcgccgtcttctcagcc
gccgcgagcaactggctgtacctggccaagctgtcgtcggtggggagcatctcagaggag
gagacgtgcgagaaactcaagggcctgatccagaggcaggtgcagatgtgcaagcggaac
ctggaagtcatggactcggtgcgccgcggtgcccagctggccattgaggagtgccagtac
cagttccggaaccggcgctggaactgctccacactcgactccttgcccgtcttcggcaag
gtggtgacgcaagggactcgggaggcggccttcgtgtacgccatctcttcggcaggtgtg
gcctttgcagtgacgcgggcgtgcagcagtggggagctggagaagtgcggctgtgacagg
acagtgcatggggtcagcccacagggcttccagtggtcaggatgctctgacaacatcgcc
tacggtgtggccttctcacagtcgtttgtggatgtgcgggagagaagcaagggggcctcg
tccagcagagccctcatgaacctccacaacaatgaggccggcaggaaggccatcctgaca
cacatgcgggtggaatgcaagtgccacggggtgtcaggctcctgtgaggtaaagacgtgc
tggcgagccgtgccgcccttccgccaggtgggtcacgcactgaaggagaagtttgatggt
gccactgaggtggagccacgccgcgtgggctcctccagggcactggtgccacgcaacgca
cagttcaagccgcacacagatgaggacctggtgtacttggagcctagccccgacttctgt
gagcaggacatgcgcagcggcgtgctgggcacgaggggccgcacatgcaacaagacgtcc
aaggccatcgacggctgtgagctgctgtgctgtggccgcggcttccacacggcgcaggtg
gagctggctgaacgctgcagctgcaaattccactggtgctgcttcgtcaagtgccggcag
tgccagcggctcgtggagttgcacacgtgccgatga

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