Homo sapiens (human): 5580 Help Entry 5580              CDS       T01001                                  Gene name PRKCD, ALPS3, CVID9, MAY1, PKCD, nPKC-delta Definition (RefSeq) protein kinase C delta   KO K06068   novel protein kinase C delta type [EC:2.7.11.13] Organism hsa  Homo sapiens (human) Pathway hsa04062   Chemokine signaling pathway hsa04140   Autophagy - animal hsa04270   Vascular smooth muscle contraction hsa04621   NOD-like receptor signaling pathway hsa04625   C-type lectin receptor signaling pathway hsa04666   Fc gamma R-mediated phagocytosis hsa04722   Neurotrophin signaling pathway hsa04750   Inflammatory mediator regulation of TRP channels hsa04912   GnRH signaling pathway hsa04915   Estrogen signaling pathway hsa04930   Type II diabetes mellitus hsa04931   Insulin resistance hsa04933   AGE-RAGE signaling pathway in diabetic complications hsa05020   Prion disease hsa05131   Shigellosis hsa05415   Diabetic cardiomyopathy Network nt06415  PI3K signaling nt06465  Prion disease   Element N01204   PRNP-PI3K-NOX2 signaling pathway N01205   Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway Disease H00108   Autoimmune lymphoproliferative syndromes Drug target Delcasertib (DG02094):  D10456 D10457 Safingol:  D05784 Safingol hydrochloride:  D05785 Sotrastaurin (DG01406):  D09671 D09718 Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     5580 (PRKCD)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     5580 (PRKCD)    04625 C-type lectin receptor signaling pathway     5580 (PRKCD)    04666 Fc gamma R-mediated phagocytosis     5580 (PRKCD)    04062 Chemokine signaling pathway     5580 (PRKCD)   09152 Endocrine system    04912 GnRH signaling pathway     5580 (PRKCD)    04915 Estrogen signaling pathway     5580 (PRKCD)   09153 Circulatory system    04270 Vascular smooth muscle contraction     5580 (PRKCD)   09156 Nervous system    04722 Neurotrophin signaling pathway     5580 (PRKCD)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     5580 (PRKCD)  09160 Human Diseases   09171 Infectious disease: bacterial    05131 Shigellosis     5580 (PRKCD)   09164 Neurodegenerative disease    05020 Prion disease     5580 (PRKCD)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     5580 (PRKCD)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     5580 (PRKCD)    04931 Insulin resistance     5580 (PRKCD)    04933 AGE-RAGE signaling pathway in diabetic complications     5580 (PRKCD)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     5580 (PRKCD) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.13  protein kinase C      5580 (PRKCD) Protein kinases [BR:hsa01001]  Serine/threonine kinases: AGC group   PKC family [OT]    5580 (PRKCD) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr C1_1 Pkinase_C zf-RING-like C1_2 Kinase-like Zf_RING ABC1 zf-RING_9 PHD Pkinase_fungal DZR APH FtrD-like FYVE_2 Motif Other DBs NCBI-GeneID:  5580 NCBI-ProteinID:  NP_001303256 OMIM:  176977 HGNC:  9399 Ensembl:  ENSG00000163932 Vega:  OTTHUMG00000133659 Pharos:  Q05655(Tclin) UniProt:  Q05655 B4DFV1 A0A024R328 LinkDB All DBs Structure PDB:  1YRK 2YUU Thumbnails Position 3p21.1 AA seq 676 aa AA seqDB search MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF AGFSFVNPKFEHLLED NT seq 2031 nt NT seq  +upstreamnt  +downstreamnt atggcgccgttcctgcgcatcgccttcaactcctatgagctgggctccctgcaggccgag gacgaggcgaaccagcccttctgtgccgtgaagatgaaggaggcgctcagcacagagcgt gggaaaacactggtgcagaagaagccgaccatgtatcctgagtggaagtcgacgttcgat gcccacatctatgaggggcgcgtcatccagattgtgctaatgcgggcagcagaggagcca gtgtctgaggtgaccgtgggtgtgtcggtgctggccgagcgctgcaagaagaacaatggc aaggctgagttctggctggacctgcagcctcaggccaaggtgttgatgtctgttcagtat ttcctggaggacgtggattgcaaacagtctatgcgcagtgaggacgaggccaagttccca acgatgaaccgccgcggagccatcaaacaggccaaaatccactacatcaagaaccatgag tttatcgccaccttctttgggcaacccaccttctgttctgtgtgcaaagactttgtctgg ggcctcaacaagcaaggctacaaatgcaggcaatgtaacgctgccatccacaagaaatgc atcgacaagatcatcggcagatgcactggcaccgcggccaacagccgggacactatattc cagaaagaacgcttcaacatcgacatgccgcaccgcttcaaggttcacaactacatgagc cccaccttctgtgaccactgcggcagcctgctctggggactggtgaagcagggattaaag tgtgaagactgcggcatgaatgtgcaccataaatgccgggagaaggtggccaacctctgc ggcatcaaccagaagcttttggctgaggccttgaaccaagtcacccagagagcctcccgg agatcagactcagcctcctcagagcctgttgggatatatcagggtttcgagaagaagacc ggagttgctggggaggacatgcaagacaacagtgggacctacggcaagatctgggagggc agcagcaagtgcaacatcaacaacttcatcttccacaaggtcctgggcaaaggcagcttc gggaaggtgctgcttggagagctgaagggcagaggagagtactttgccatcaaggccctc aagaaggatgtggtcctgatcgacgacgacgtggagtgcaccatggttgagaagcgggtg ctgacacttgccgcagagaatccctttctcacccacctcatctgcaccttccagaccaag gaccacctgttctttgtgatggagttcctcaacgggggggacctgatgtaccacatccag gacaaaggccgctttgaactctaccgtgccacgttttatgccgctgagataatgtgtgga ctgcagtttctacacagcaagggcatcatttacagggacctcaaactggacaatgtgctg ctggaccgggatggccacatcaagattgccgactttgggatgtgcaaagagaacatattc ggggagagccgggccagcaccttctgcggcacccctgactatatcgcccctgagatccta cagggcctgaagtacacattctctgtggactggtggtctttcggggtccttctgtacgag atgctcattggccagtcccccttccatggtgatgatgaggatgaactcttcgagtccatc cgtgtggacacgccacattatccccgctggatcaccaaggagtccaaggacatcctggag aagctctttgaaagggaaccaaccaagaggctgggagtgaccggaaacatcaaaatccac cccttcttcaagaccataaactggactctgctggaaaagcggaggttggagccacctttc aggcccaaagtgaagtcacccagagactacagtaactttgaccaggagttcctgaacgag aaggcgcgcctctcctacagcgacaagaacctcatcgactccatggaccagtctgcattc gctggcttctcctttgtgaaccccaaattcgagcacctcctggaagattga

Homo sapiens (human): 5581 Help Entry 5581              CDS       T01001                                  Gene name PRKCE, PKCE, nPKC-epsilon Definition (RefSeq) protein kinase C epsilon   KO K18050   novel protein kinase C epsilon type [EC:2.7.11.13] Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04071   Sphingolipid signaling pathway hsa04270   Vascular smooth muscle contraction hsa04371   Apelin signaling pathway hsa04530   Tight junction hsa04666   Fc gamma R-mediated phagocytosis hsa04750   Inflammatory mediator regulation of TRP channels hsa04925   Aldosterone synthesis and secretion hsa04930   Type II diabetes mellitus hsa04931   Insulin resistance hsa04933   AGE-RAGE signaling pathway in diabetic complications hsa05131   Shigellosis hsa05206   MicroRNAs in cancer Drug target Safingol:  D05784 Safingol hydrochloride:  D05785 Sotrastaurin (DG01406):  D09671 D09718 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     5581 (PRKCE)    04071 Sphingolipid signaling pathway     5581 (PRKCE)    04022 cGMP-PKG signaling pathway     5581 (PRKCE)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04530 Tight junction     5581 (PRKCE)  09150 Organismal Systems   09151 Immune system    04666 Fc gamma R-mediated phagocytosis     5581 (PRKCE)   09152 Endocrine system    04925 Aldosterone synthesis and secretion     5581 (PRKCE)   09153 Circulatory system    04270 Vascular smooth muscle contraction     5581 (PRKCE)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     5581 (PRKCE)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     5581 (PRKCE)   09171 Infectious disease: bacterial    05131 Shigellosis     5581 (PRKCE)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     5581 (PRKCE)    04931 Insulin resistance     5581 (PRKCE)    04933 AGE-RAGE signaling pathway in diabetic complications     5581 (PRKCE)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     5581 (PRKCE) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.13  protein kinase C      5581 (PRKCE) Protein kinases [BR:hsa01001]  Serine/threonine kinases: AGC group   PKC family [OT]    5581 (PRKCE) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C ABC1 FTA2 Kinase-like Kdo Motif Other DBs NCBI-GeneID:  5581 NCBI-ProteinID:  NP_005391 OMIM:  176975 HGNC:  9401 Ensembl:  ENSG00000171132 Vega:  OTTHUMG00000128817 Pharos:  Q02156(Tchem) UniProt:  Q02156 L7RTI5 LinkDB All DBs Structure PDB:  2WH0 Thumbnails Position 2p21 AA seq 737 aa AA seqDB search MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI NQEEFKGFSYFGEDLMP NT seq 2214 nt NT seq  +upstreamnt  +downstreamnt atggtagtgttcaatggccttcttaagatcaaaatctgcgaggccgtgagcttgaagccc acagcctggtcgctgcgccatgcggtgggaccccggccgcagactttccttctcgacccc tacattgccctcaatgtggacgactcgcgcatcggccaaacggccaccaagcagaagacc aacagcccggcctggcacgacgagttcgtcaccgatgtgtgcaacggacgcaagatcgag ctggctgtctttcacgatgcccccataggctacgacgacttcgtggccaactgcaccatc cagtttgaggagctgctgcagaacgggagccgccacttcgaggactggattgatctggag ccagaaggaagagtgtatgtgatcatcgatctctcagggtcgtcgggtgaagcccctaaa gacaatgaagagcgtgtgttcagggaacgcatgcggccgaggaagcggcagggggccgtc aggcgcagggtccatcaggtcaacggccacaagttcatggccacctatcttcggcagccc acctactgctcccattgcagagacttcatctggggtgtcataggaaagcagggataccag tgtcaagtctgcacctgcgtggtccacaagcggtgccacgagctcataatcacaaagtgt gctgggttaaagaagcaggagacccccgaccaggtgggctcccagcggttcagcgtcaac atgccccacaagttcggtatccacaactacaaggtccctaccttctgcgatcactgtggg tccctgctctggggactcttgcggcagggtttgcagtgtaaagtctgcaaaatgaatgtt caccgtcgatgtgagaccaacgtggctcccaactgtggagtggatgccagaggaatcgcc aaagtactggccgacctgggcgttaccccagacaaaatcaccaacagcggccagagaagg aaaaagctcattgctggtgccgagtccccgcagcctgcttctggaagctcaccatctgag gaagatcgatccaagtcagcacccacctccccttgtgaccaggaaataaaagaacttgag aacaacattcggaaagccttgtcatttgacaaccgaggagaggagcaccgggcagcatcg tctcctgatggccagctgatgagccccggtgagaatggcgaagtccggcaaggccaggcc aagcgcctgggcctggatgagttcaacttcatcaaggtgttgggcaaaggcagctttggc aaggtcatgttggcagaactcaagggcaaagatgaagtatatgctgtgaaggtcttaaag aaggacgtcatccttcaggatgatgacgtggactgcacaatgacagagaagaggattttg gctctggcacggaaacacccgtaccttacccaactctactgctgcttccagaccaaggac cgcctctttttcgtcatggaatatgtaaatggtggagacctcatgtttcagattcagcgc tcccgaaaattcgacgagcctcgttcacggttctatgctgcagaggtcacatcggccctc atgttcctccaccagcatggagtcatctacagggatttgaaactggacaacatccttctg gatgcagaaggtcactgcaagctggctgacttcgggatgtgcaaggaagggattctgaat ggtgtgacgaccaccacgttctgtgggactcctgactacatagctcctgagatcctgcag gagttggagtatggcccctccgtggactggtgggccctgggggtgctgatgtacgagatg atggctggacagcctccctttgaggccgacaatgaggacgacctatttgagtccatcctc catgacgacgtgctgtacccagtctggctcagcaaggaggctgtcagcatcttgaaagct ttcatgacgaagaatccccacaagcgcctgggctgtgtggcatcgcagaatggcgaggac gccatcaagcagcacccattcttcaaagagattgactgggtgctcctggagcagaagaag atcaagccacccttcaaaccacgcattaaaaccaaaagagacgtcaataattttgaccaa gactttacccgggaagagccggtactcacccttgtggacgaagcaattgtaaagcagatc aaccaggaggaattcaaaggtttctcctactttggtgaagacctgatgccctga

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