KEGG ORTHOLOGY: K06068

ORTHOLOGY: K06068

Entry

K06068                      KO

Symbol

PRKCD

Name

novel protein kinase C delta type [EC:2.7.11.13]

Pathway

map04062

Chemokine signaling pathway

map04140

Autophagy - animal

map04270

Vascular smooth muscle contraction

map04361

Axon regeneration

map04621

NOD-like receptor signaling pathway

map04625

C-type lectin receptor signaling pathway

map04666

Fc gamma R-mediated phagocytosis

map04722

Neurotrophin signaling pathway

map04750

Inflammatory mediator regulation of TRP channels

map04912

GnRH signaling pathway

map04915

Estrogen signaling pathway

map04930

Type II diabetes mellitus

map04931

Insulin resistance

map04933

AGE-RAGE signaling pathway in diabetic complications

map05020

Prion disease

map05131

Shigellosis

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Disease

H00108

Autoimmune lymphoproliferative syndromes

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K06068  PRKCD; novel protein kinase C delta type
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
   04625 C-type lectin receptor signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
   04666 Fc gamma R-mediated phagocytosis
    K06068  PRKCD; novel protein kinase C delta type
   04062 Chemokine signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
  09152 Endocrine system
   04912 GnRH signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
   04915 Estrogen signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K06068  PRKCD; novel protein kinase C delta type
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K06068  PRKCD; novel protein kinase C delta type
  09158 Development and regeneration
   04361 Axon regeneration
    K06068  PRKCD; novel protein kinase C delta type
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K06068  PRKCD; novel protein kinase C delta type
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K06068  PRKCD; novel protein kinase C delta type
  09164 Neurodegenerative disease
   05020 Prion disease
    K06068  PRKCD; novel protein kinase C delta type
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K06068  PRKCD; novel protein kinase C delta type
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K06068  PRKCD; novel protein kinase C delta type
   04931 Insulin resistance
    K06068  PRKCD; novel protein kinase C delta type
   04933 AGE-RAGE signaling pathway in diabetic complications
    K06068  PRKCD; novel protein kinase C delta type
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06068  PRKCD; novel protein kinase C delta type
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     K06068  PRKCD; novel protein kinase C delta type
Protein kinases [BR:ko01001]
Serine/threonine kinases: AGC group
  PKC family [OT]
   K06068  PRKCD; novel protein kinase C delta type

Other DBs

GO:

0004699

Genes

HSA:	5580(PRKCD)

PTR:	460442(PRKCD)

PPS:	100978487(PRKCD)

GGO:	101133370(PRKCD)

PON:	100452668(PRKCD)

PPYG:

129034252(PRKCD)

NLE:	100591028(PRKCD)

HMH:	116473376(PRKCD)

SSYN:

129480500(PRKCD)

MCC:	694656(PRKCD)

MCF:	102136158(PRKCD)

MTHB:

126948783

MNI:	105480568(PRKCD)

CSAB:

103227755(PRKCD)

CATY:

105585581(PRKCD)

PANU:

101003920(PRKCD)

TGE:	112619188(PRKCD)

MLEU:

105543983(PRKCD)

RRO:	104672393(PRKCD)

RBB:	108515204(PRKCD)

TFN:	117082999(PRKCD)

PTEH:

111524359(PRKCD)

CANG:

105515446(PRKCD)

CJC:	100395399(PRKCD)

SBQ:	101044546(PRKCD)

CIMI:

108304989(PRKCD)

ANAN:

105722920(PRKCD)

CSYR:

103268097(PRKCD)

MMUR:

105875067(PRKCD)

LCAT:

123623170(PRKCD)

PCOQ:

105805862(PRKCD)

OGA:	100951664(PRKCD)

MMU:	18753(Prkcd)

MCAL:

110309154(Prkcd)

MPAH:

110326026(Prkcd)

RNO:	170538(Prkcd)

MCOC:

116085415(Prkcd)

ANU:	117705965(Prkcd)

MUN:	110547587(Prkcd)

CGE:	100774348(Prkcd)

MAUA:

101842470(Prkcd)

PROB:

127236861(Prkcd)

PLEU:

114708186(Prkcd)

MORG:

121455195(Prkcd)

MFOT:

126511136

AAMP:

119827346(Prkcd)

NGI:	103749021(Prkcd)

HGL:	101718422(Prkcd)

CPOC:

100726624(Prkcd)

CCAN:

109693718(Prkcd)

DORD:

105996605(Prkcd)

DSP:	122107987(Prkcd)

PLOP:

125358588(Prkcd)

NCAR:

124968791

MMMA:

107149626(Prkcd)

OCU:

100008966

OPI:	101523591(PRKCD)

TUP:	102487574(PRKCD)

GVR:	103598537(PRKCD)

CFA:	494005(PRKCD)

CLUD:

112665911(PRKCD)

VVP:	112910129(PRKCD)

VLG:	121495996(PRKCD)

NPO:	129522341(PRKCD)

AML:	100481918(PRKCD)

UMR:	103674744(PRKCD)

UAH:	113256975(PRKCD)

UAR:	123798757(PRKCD)

ELK:

111144045

LLV:

125078754

MPUF:

101675130(PRKCD)

MNP:	132011420(PRKCD)

MLK:	131824034(PRKCD)

NVS:	122909342(PRKCD)

ORO:	101385728(PRKCD)

EJU:	114225007(PRKCD)

ZCA:	113918529(PRKCD)

MLX:	118005176(PRKCD)

NSU:	110584785(PRKCD)

LWW:	102730196 102751076

FCA:	101087716(PRKCD)

PYU:	121016847(PRKCD)

PCOO:

112852480(PRKCD)

PBG:	122487327(PRKCD)

PVIV:

125160334(PRKCD)

LRUF:

124523091

PTG:	102959855(PRKCD)

PPAD:

109247926(PRKCD)

PUC:

125929472

AJU:

106987049

HHV:	120239415(PRKCD)

BTA:	505708(PRKCD)

BOM:	102273901(PRKCD)

BIU:	109576388(PRKCD)

BBUB:

102407491(PRKCD)

BBIS:

104997117(PRKCD)

CHX:	102171471(PRKCD)

OAS:	101107639(PRKCD)

BTAX:

128044536(PRKCD)

ODA:	120868385(PRKCD)

CCAD:

122424790(PRKCD)

MBEZ:

129547928(PRKCD)

SSC:	100622955(PRKCD)

CFR:	102511255(PRKCD)

CBAI:

105080156(PRKCD)

CDK:	105093214(PRKCD)

VPC:	102537750(PRKCD)

BACU:

103000809(PRKCD)

BMUS:

118904172(PRKCD)

LVE:	103073166(PRKCD)

OOR:	101275504(PRKCD)

DLE:	111174287(PRKCD)

PCAD:

102984279(PRKCD)

PSIU:

116762083(PRKCD)

NASI:

112400532(PRKCD)

ECB:	100051333(PRKCD)

EPZ:	103546514(PRKCD)

EAI:	106822994(PRKCD)

MYB:	102256501(PRKCD)

MYD:	102760591(PRKCD)

MMYO:

118667983(PRKCD)

MLF:	102431901(PRKCD)

MDT:	132215291(PRKCD)

PKL:	118715126(PRKCD)

EFUS:

103290422(PRKCD)

MNA:	107534935(PRKCD)

DRO:	112301220(PRKCD)

SHON:

118983341(PRKCD)

AJM:	119041430(PRKCD)

PDIC:

114501653(PRKCD)

PHAS:

123814537(PRKCD)

MMF:	118633138(PRKCD)

PPAM:

129087905(PRKCD)

HAI:	109395953(PRKCD)

RFQ:	117037221(PRKCD)

PALE:

102888600(PRKCD)

PGIG:

120606307(PRKCD)

PVP:	105304348(PRKCD)

RAY:	107516555(PRKCD)

MJV:	108408298(PRKCD)

TOD:	119261357(PRKCD)

SARA:

101547708(PRKCD)

SETR:

126013204(PRKCD)

LAV:	100659245(PRKCD)

TMU:

101355651

ETF:	101650810(PRKCD)

DNM:	101440758(PRKCD)

MDO:	100030722(PRKCD)

GAS:	123230752(PRKCD)

SHR:	100925245(PRKCD)

AFZ:

127553769

PCW:	110197529(PRKCD)

TVP:	118831538(PRKCD)

OAA:	100088214(PRKCD)

GGA:	415905(PRKCD)

PCOC:

116232318(PRKCD)

MGP:	100541931(PRKCD)

CJO:	107319581(PRKCD)

TPAI:

128078325(PRKCD)

LMUT:

125698774(PRKCD)

NMEL:

110404811(PRKCD)

APLA:

101796703(PRKCD)

ACYG:

106042845(PRKCD)

CATA:

118248261(PRKCD)

AFUL:

116492904(PRKCD)

TGU:	100230711(PRKCD)

LSR:	110469913(PRKCD)

SCAN:

103816971(PRKCD)

PMOA:

120495685(PRKCD)

OTC:	121347200(PRKCD)

PRUF:

121352257(PRKCD)

GFR:	102031450(PRKCD)

FAB:	101806370(PRKCD)

OMA:	130258495(PRKCD)

PHI:	102111760(PRKCD)

PMAJ:

107210274(PRKCD)

CCAE:

111935183(PRKCD)

CCW:	104683217(PRKCD)

CBRC:

103614258(PRKCD)

ETL:	114058791(PRKCD)

ZAB:	102071110(PRKCD)

ACHL:

103807716(PRKCD)

SVG:	106849217(PRKCD)

MMEA:

130574657(PRKCD)

HRT:	120758436(PRKCD)

SATI:

136366040(PRKCD)

FPG:	101920231(PRKCD)

FCH:	102049783(PRKCD)

CCRI:

104163194(PRKCD)

NNT:	104410700(PRKCD)

SHAB:

115614174(PRKCD)

ACUN:

113484720(PRKCD)

TALA:

104365907(PRKCD)

ACHC:

115333335(PRKCD)

HALD:

104316544(PRKCD)

HLE:	104828117(PRKCD)

AGEN:

126049843

GCL:

127021552

CSTI:

104557431(PRKCD)

LDI:	104345396(PRKCD)

MNB:

103772630

DPUB:

104300397(PRKCD)

AVIT:

104276937(PRKCD)

BRHI:

104490479(PRKCD)

EGZ:	104126756(PRKCD)

NNI:	104008710(PRKCD)

PCRI:

104037225(PRKCD)

PCAO:

104039912(PRKCD)

PADL:

103915063(PRKCD)

AFOR:

103898254(PRKCD)

FGA:	104083293(PRKCD)

GSTE:

104261920(PRKCD)

CLV:	102091654(PRKCD)

MUI:	104537245(PRKCD)

PGUU:

104468186(PRKCD)

PLET:

104626476(PRKCD)

EHS:	104514754(PRKCD)

CMAC:

104485786

CUCA:

104066690(PRKCD)

TEO:	104374033(PRKCD)

BREG:

104637745(PRKCD)

OHA:	104336617(PRKCD)

ACAR:

104520783(PRKCD)

CPEA:

104398486(PRKCD)

CVF:	104291943(PRKCD)

RTD:	128915653(PRKCD)

AAM:	106485957(PRKCD)

AROW:

112972980(PRKCD)

NPD:	112953052(PRKCD)

TGT:	104565251(PRKCD)

DNE:	112986206(PRKCD)

SCAM:

104147015(PRKCD)

ASN:	102387772(PRKCD)

AMJ:	102571623(PRKCD)

CPOO:

109318287(PRKCD)

GGN:	109289214(PRKCD)

PSS:	102451674(PRKCD)

CMY:	102945932(PRKCD)

CCAY:

125639345(PRKCD)

DCC:	119858806(PRKCD)

CPIC:

101951475(PRKCD)

TST:	117880659(PRKCD)

CABI:

116820430(PRKCD)

MRV:	120368642(PRKCD)

ACS:	100553700(prkcd)

ASAO:

132769200(PRKCD)

PVT:	110080620(PRKCD)

SUND:

121922638(PRKCD)

PBI:	103054205(PRKCD)

PMUR:

107293197(PRKCD)

CTIG:

120310129(PRKCD)

PGUT:

117678118(PRKCD)

APRI:

131190993(PRKCD)

PTEX:

113453193(PRKCD)

NSS:	113420561(PRKCD)

VKO:	123034075(PRKCD)

PMUA:

114589765 114591604(PRKCD)

PRAF:

128408224(PRKCD)

ZVI:	118080644(PRKCD)

HCG:	128347886(PRKCD)

GJA:	107115526(PRKCD)

STOW:

125429841(PRKCD)

EMC:	129328205(PRKCD)

XTR:	116407520 116412350 733756(prkcd)

NPR:	108797915(PRKCD)

RTEM:

120916072 120945346(PRKCD)

BGAR:

122919785 122919786 122920081 122923544 122925678 122925680 122925772 122941981 122942138 122942140 122942146 122943261(PRKCD)

MUO:	115471962(PRKCD)

GSH:	117351358(PRKCD)

DRE:	100150844(prkcdb) 334571(prkcda)

SRX:	107712078 107721176 107728641 107746897

SANH:

107656045 107667398 107673500 107696837

SGH:	107558893(prkcd) 107582675 107600299

CCAR:

109054463 109063612

CAUA:

113050390 113055278 113094825 113110979

CGIB:

127959544 127968130 128015769 128022413

PTET:

122347182(prkcda) 122354305(prkcdb)

LROH:

127167169(prkcda) 127173261(prkcdb)

OMC:	131542112(prkcda) 131549725(prkcdb)

PPRM:

120480498(prkcdb) 120491486(prkcda)

RKG:	130086710(prkcdb) 130087502(prkcda)

MAMB:

125256482(prkcdb) 125273755(prkcda)

CIDE:

127514019 127522064

CERY:

137010734(prkcda) 137021605(prkcdb)

MASI:

127426272 127427978 127446241 127449299

TROS:

130556827(prkcda) 130571351(prkcdb)

TDW:	130409928(prkcdb) 130424967(prkcda)

MANU:

129427730(prkcdb) 129450529(prkcda)

IPU:	108254977(prkcdb) 108271968(prkcda)

IFU:	128614961(prkcda) 128625003(prkcdb)

PHYP:

113534377 113539572(prkcd)

SMEO:

124390632(prkcda) 124402367(prkcdb)

TFD:	113642794(prkcda) 113661884(prkcdb)

TVC:	132837939(prkcdb) 132844432(prkcda)

TRN:	134302104(prkcdb) 134316601(prkcda)

AMEX:

103030273(prkcda) 103036366(prkcdb)

CMAO:

118799424(prkcdb) 118808294(prkcda)

EEE:	113576010(prkcd)

CHAR:

105907752(prkcda) 105912157(prkcdb)

TRU:	101062863(prkcd)

TFS:	130524056(prkcda)

TNG:	GSTEN00004810G001 GSTEN00027270G001

LCO:

104933455

NCC:	104944044(prkcd)

TBEN:

117475452 117489552(prkcda)

CGOB:

115008352 115008519(prkcd)

PGEO:

117446645(prkcdb) 117447434(prkcda)

GACU:

117543783(prkcdb) 117551113(prkcda)

EMAC:

134882874 134882887(prkcda)

ELY:	117257453(prkcda)

EFO:	125891431 125891930(prkcda)

PLEP:

121955918(prkcda)

SLUC:

116041697(prkcda)

ECRA:

117943700(prkcda) 117944105(prkcdb)

ESP:	116688371 116688666

PFLV:

114553915 114554679(prkcd)

GAT:	120834638(prkcda)

PPUG:

119193971(prkcda) 119230203

AFB:	129105230 129106484(prkcda)

CLUM:

117730323 117730620(prkcda)

PSWI:

130208665 130208821(prkcda)

MSAM:

119886414(prkcda)

SCHU:

122865392 122866851(prkcda)

CUD:	121507580(prkcda)

ALAT:

119021732(prkcda)

MZE:	101471530(prkcd)

ONL:	100698031(prkcd)

OAU:	116333821(prkcda)

OLA:	101174016(prkcd)

OML:	112145195(prkcda)

CSAI:

133448765(prkcda)

XMA:	102232189(prkcd)

XCO:	114135620(prkcd)

XHE:	116710982(prkcd)

PRET:

103465249(prkcd)

PFOR:

103143216 103145765

PLAI:

106963883(prkcd) 106965019

PMEI:

106931356 106931995(prkcd)

GAF:	122834698(prkcda)

PPRL:

129358120(prkcda) 129358207

CVG:	107094023(prkcd)

CTUL:

119776675(prkcda)

GMU:	124856448(prkcda)

NFU:	107385705(prkcd)

KMR:	108235712(prkcda)

ALIM:

106518011(prkcd)

NWH:	119411922(prkcda)

AOCE:

111566615(prkcd)

MCEP:

125006281(prkcda)

CSEM:

103385936(prkcd)

POV:	109629305(prkcd)

SSEN:

122768025(prkcda)

HHIP:

117761354(prkcda)

HSP:	118105172(prkcda)

PPLT:

128425234(prkcda) 128453300

SMAU:

118309613 118309678(prkcda)

LCF:	108881487(prkcda)

SDU:	111221681(prkcd) 111221709

SLAL:

111667849(prkcd) 111670988

XGL:	120807519(prkcda)

HCQ:

109522455

SSCV:

125977529 125977811

SBIA:

133506921 133507552(prkcda)

PEE:	133408426 133408622(prkcda)

PTAO:

133483033 133483847(prkcda)

BPEC:

110168367(prkcd)

MALB:

109964491

BSPL:

114855205(prkcda)

SJO:	128354994 128355592(prkcda)

SASA:

100195900(kpcd) 106565545 106565827 106583214(KPCD) 106595901

STRU:

115150559 115150786 115207643 115207853

OTW:	112217414(prkcda) 112219327 112254422 112254618

OMY:	110494302(prkcda) 110494510 110527955 110528134

OGO:	124002983 124016910 124031271 124031434

ONE:	115138121 115143158 115143328

OKI:	109891002 109891155 109895618 109897123

OKE:	118388418 118388586(prkcda) 118399847 118400310

SALP:

111966617 111968570 111969929 111970102

SNH:	120025310(prkcda) 120059307 120065197 120065610

CCLU:

121574964 121575240(prkcda) 121577601 121578203

ELS:	105017197(prkcd) 105017308

SFM:	108923432 108936999

PKI:	111839856 111840581

AANG:

118207526 118207872 118210592

LOC:	102698207(prkcd)

PSPA:

121298104 121328340

ARUT:

117412065 117962609

PSEX:

120540466

LCM:	102367474(PRKCD)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116942323 116952362 116952762

LRJ:	133349514 133355397 133356643

BFO:

BBEL:

SCLV:

LPIC:

ARUN:

AJC:

DME:	Dmel_CG42349(Pkcdelta)

DER:

6551361

DSI:	Dsimw501_GD17078(Dsim_GD17078)

DYA:	Dyak_GE17008

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21641

DAZ:

DHE:

CCAT:

BDR:

RZE:

TDA:

LCQ:

LSQ:

CQU:	CpipJ_CPIJ019407

TCA:

658064

SOY:	115886471 115886576

CSET:

LDC:

APLN:

PPYR:

OTU:

LGLY:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

DCI:

HHAL:

106692631(Pkcdelta)

NLU:	120353949 120353950 120353989

MQU:

128994256

PHU:	Phum_PHUM544690

TPAL:

IEL:

DMK:

DPZ:

LSM:

PPOI:

DFR:

CVS:	136975667 136989827

UDV:

129231853

LPOL:

106458922 106467740 106471012

CEL:	CELE_B0545.1(tpa-1)

CBR:	CBG_01645(Cbr-tpa-1)

CRQ:	GCK72_014663

TSP:

PVUL:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:	111107462 111107852

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LLON:

ATEN:

XEN:

HSY:

RES:

NCOL:

VNX:	VNE69_03317

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Reference

PMID:21103796

Authors

Basu A, Pal D

Title

Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death.

Journal

ScientificWorldJournal 10:2272-84 (2010)
DOI:10.1100/tsw.2010.214

Reference

PMID:12473183

Authors

Kikkawa U, Matsuzaki H, Yamamoto T

Title

Protein kinase C delta (PKC delta): activation mechanisms and functions.

Journal

J Biochem 132:831-9 (2002)
DOI:10.1093/oxfordjournals.jbchem.a003294

Reference

PMID:8357834

Authors

Aris JP, Basta PV, Holmes WD, Ballas LM, Moomaw C, Rankl NB, Blobel G, Loomis CR, Burns DJ

Title

Molecular and biochemical characterization of a recombinant human PKC-delta family member.

Journal

Biochim Biophys Acta 1174:171-81 (1993)
DOI:10.1016/0167-4781(93)90111-P

Sequence

[hsa:5580]

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