Homo sapiens (human): 57520
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Entry
57520 CDS
T01001
Symbol
HECW2, NDHSAL, NEDL2
Name
(RefSeq) HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
KO
K12168
E3 ubiquitin-protein ligase HECW2 [EC:
2.3.2.26
]
Organism
hsa
Homo sapiens (human)
Disease
H02715
Neurodevelopmental disorder with defects of ubiquitin-proteasome system
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
57520 (HECW2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
57520 (HECW2)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
HECT type E3
57520 (HECW2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HECT
HECW_N
HECW1_helix
WW
C2
RFXA_RFXANK_bdg
Motif
Other DBs
NCBI-GeneID:
57520
NCBI-ProteinID:
NP_065811
OMIM:
617245
HGNC:
29853
Ensembl:
ENSG00000138411
UniProt:
Q9P2P5
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:complement(196194072..196593554)
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AA seq
1572 aa
AA seq
DB search
MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSS
LTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQ
IVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGASGNLH
SRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTT
NPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLS
YNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGTILGVNSVNGDLGSPSDDEDMPGS
HHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQDSLNDYL
DAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPS
SLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAESS
LPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETES
LDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRC
SSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEGP
GAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGG
SQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTA
PPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRR
ENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRD
THHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL
QSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVA
YNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLS
LFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNF
YRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSG
PSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIH
QYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVF
GQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSV
FDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFV
TGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLL
TAVEETSTFGLE
NT seq
4719 nt
NT seq
+upstream
nt +downstream
nt
atggctagttcagcccgggagcacctgctttttgtgaggcgtcgaaatccccagatgcgg
tacacattgagcccagagaacctccagagccttgccgcccagagctccatgccagagaac
atgaccctgcagcgggccaacagcgacaccgacctggtgacttctgagagccgctccagc
ttaactgccagcatgtacgagtacacgctggggcaagcccagaacctcattatcttctgg
gacattaaagaggaggtggaccccagtgattggattggactttatcatatagatgagaat
tctccagccaacttctgggattctaagaacaggggtgtgactggaacacaaaaagggcaa
attgtatggagaattgagcctgggccctatttcatggaaccggagataaaaatctgtttt
aaatattaccacggcattagtggagccctgcgagccacgaccccctgcatcaccgtgaag
aacccagctgtgatgatgggggcagaaggcatggagggaggtgcttcaggaaacctgcat
tctcgaaaacttgttagctttacattgtcagatcttagggcagttgggctaaagaaaggg
atgttcttcaatcctgacccttatcttaagatgtcaattcagccaggaaagaagagcagt
ttccccacctgtgcccaccacgggcaggagagacggtctactatcatcagtaacaccacc
aatccaatttggcaccgagagaaatattccttttttgcacttcttactgatgtcttagaa
attgaaattaaagacaaatttgccaagagccgtcccatcatcaagcgttttctggggaaa
ctaaccattccagtccagaggctgctggagcgacaagccatcggtgatcaaatgctcagc
tacaaccttggcagaaggctcccagctgaccacgtgagtgggtacctccagtttaaagtg
gaggttacgtcttctgttcatgaagatgcctctccagaagctgttggcacaatacttgga
gtcaattctgtgaatggagacttaggtagcccttccgatgacgaggacatgccagggagc
catcacgacagccaggtgtgctctaatgggccagtttctgaggacagtgctgccgatgga
acccccaagcattcattcaggactagctccactctggaaatagacacagaggaattaacc
tctacgtcttcaaggacctcacctcccagaggacgtcaggattcactcaatgattactta
gatgctatcgaacacaatggccactccaggccggggacagcgacctgctctgagaggtcc
atgggtgcctctccgaaactgaggagtagttttcccactgacacaagactcaatgccatg
cttcatattgattcagatgaagaagatcacgagttccagcaagacctgggttacccatct
tccttggaggaggagggaggcctgatcatgtttagcagggcatccagagctgatgatgga
agcctgacatctcagacaaagctggaggacaaccctgttgagaatgaggaagcctccaca
cacgaagctgcttcctttgaggataagccagaaaatcttccagagcttgcagagagctcc
ttacctgcaggcccagccccagaggaaggtgaaggcggcccagagcctcaacccagtgct
gaccagggcagtgctgaactgtgtggctctcaagaggtagatcagcccacaagtggcgca
gacacagggacttccgatgcatcaggaggaagccgaagagccgtcagtgagaccgagtct
ctcgatcagggctctgagccttcccaggtgtcctctgaaacagaacccagtgatcctgcc
aggacagagagtgtgagcgaagccagcaccaggcctgagggagagagtgacctggaatgc
gctgacagctcctgcaatgagagtgtgaccacgcagctgtcctctgtggacacacggtgc
tcctctcttgagagcgcacggtttcctgaaaccccagccttttcttctcaggaggaggaa
gacggagcctgtgcagcagagcccaccagcagtggccctgccgaagggtcgcaggaatcc
gtgtgcactgctggttctttacctgtggtacaggtgcccagtggggaggatgaagggcca
ggggcagaatcggccactgtacctgaccaggaggagctgggggaggtctggcagcggagg
gggagcctggagggagctgcagctgctgccgagagcccaccgcaagaagaaggcagtgct
ggggaggcccaaggcacctgtgaaggggcaactgcccaggaggagggcgctactggaggt
tctcaagccaacggccaccagccactgcgatcactaccttcagtgcgccaggatgttagc
cggtaccagagggtggacgaggctctcccaccaaactgggaggcacgcattgacagccac
ggcaggatcttctacgtggatcacgtaaacagaaccacgacgtggcagcgaccgacagct
cccccagccccgcaggtgctgcagagatctaactccatacagcaaatggagcagctgaac
cggcgatatcagagtatccgcagaaccatgaccaatgagaggcctgaggaaaataccaat
gctattgatggggcaggggaggaagctgactttcaccaagccagtgcagatttccgacgg
gagaacatcctgcctcactctacctccagatccaggatcacgttgctgttacagtctccc
cccgtgaagttcctcatcagcccagagttcttcaccgtgctgcattctaaccctagtgcc
taccgcatgtttacaaacaacacgtgtttgaagcacatgatcaccaaagtccggagggac
acccaccactttgaacgctaccagcataaccgcgaccttgtgggattcctcaacatgttc
gcgaacaaacagctagagctgccgcggggatgggaaatgaaacatgatcaccagggcaag
gcattctttgtggaccacaactcccgcaccaccactttcattgatccccggctcccactt
cagagcagtagacccacaagtgcgctggttcatcggcaacacctgacaaggcaacgcagc
cacagtgcgggtgaggtaggagaagattctcgacatgcaggaccaccagttcttcccagg
ccatccagtacattcaatacagtcagtaggccacagtaccaggacatggttccagtggct
tacaatgacaagattgttgcatttctacgtcaacccaatatctttgaaattctacaggag
cgtcaacctgatcttaccaggaatcactcactcagggagaagatccaatttatccgaact
gaagggactccaggattggtgcgcctttcaagcgatgcagaccttgttatgttgctgagc
ttatttgaagaagagataatgtcgtatgtgcctccacatgccttactccaccccagctac
tgtcagtccccacgtggctctcccgtgtcatctcctcagaactcgccaggtacccagcgt
gccaatgcccgggctccagccccttacaagcgggatttcgaagccaaactgaggaacttt
tacaggaagttagagactaaaggatatggacaaggcccagggaagttaaagttaattatc
cgaagagatcacttactagaagatgcttttaatcagattatgggctactccagaaaagac
ctgcagagaaataagctatatgtcaccttcgttggggaggaagggctggattacagtggg
ccttctagagagtttttcttcctggtatccagagaactctttaacccatattatggctta
tttgaatattcagccaatgacacatacacagtacaaataagtcctatgtctgcttttgta
gacaatcaccatgaatggttccgattcagtggtaggatccttggtcttgcactaatacac
cagtatttgttggatgccttcttcacacggcccttttataaggctcttctcagaattcta
tgtgacctgagtgacctagaataccttgatgaagagttccatcagagcctgcagtggatg
aaagacaatgatatccatgacatcctagacctcacgttcactgtgaacgaagaagtattt
gggcagataactgaacgagaattaaagccagggggtgccaatatcccagttacagagaag
aacaagaaggagtacatcgagaggatggtgaagtggaggattgagaggggtgttgtacag
caaacagagagcttagtgcgtggcttctatgaggtggtggatgccaggctggtatctgtt
tttgatgcaagagaactggaattggtcatcgcaggcacagctgaaatagacctaagtgat
tggagaaacaacacagaatatagaggaggataccatgacaatcatattgtaattcggtgg
ttctgggctgcagtggaaagattcaacaatgaacaacgactaaggttgttacagtttgtt
acaggcacatccagcattccctatgaaggatttgcttcactccgagggagtaacggccca
agaagattctgtgtggagaaatgggggaaaatcactgctcttcccagagcgcatacatgt
tttaaccgtctggatctgcctccctacccatccttttccatgctttatgaaaaactgttg
acagcagttgaagaaaccagtacttttggacttgagtga
DBGET
integrated database retrieval system
