Homo sapiens (human): 57657
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Entry
57657 CDS
T01001
Symbol
HCN3
Name
(RefSeq) hyperpolarization activated cyclic nucleotide gated potassium channel 3
KO
K04956
hyperpolarization activated cyclic nucleotide-gated potassium channel 3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04929
GnRH secretion
Network
nt06544
Neuroactive ligand signaling
Element
N01905
AC-PKA-HCN signaling
Drug target
Ivabradine (
DG00246
):
D07165
D08095
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04929 GnRH secretion
57657 (HCN3)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
57657 (HCN3)
Ion channels [BR:
hsa04040
]
Voltage-gated cation channels
Cyclic nucleotide-gated channel (HCN)
57657 (HCN3)
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SSDB
Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Ion_trans
Ion_trans_N
cNMP_binding
Ion_trans_2
Motif
Other DBs
NCBI-GeneID:
57657
NCBI-ProteinID:
NP_065948
OMIM:
609973
HGNC:
19183
Ensembl:
ENSG00000143630
UniProt:
Q9P1Z3
Structure
PDB
PDBj
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All DBs
Position
1:155277463..155289848
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AA seq
774 aa
AA seq
DB search
MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKF
SLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE
ENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISS
IPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHM
TYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH
ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQY
QEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCR
GLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGA
RDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVA
MDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKP
VLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPV
RAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLP
QRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM
NT seq
2325 nt
NT seq
+upstream
nt +downstream
nt
atggaggcagagcagcggccggcggcgggggccagcgaaggggcgacccctggactggag
gcggtgcctcccgttgctcccccgcctgcgaccgcggcctcaggtccgatccccaaatct
gggcctgagcctaagaggaggcaccttgggacgctgctccagcctacggtcaacaagttc
tcccttcgggtgttcggcagccacaaagcagtggaaatcgagcaggagcgggtgaagtca
gcgggggcctggatcatccacccctacagcgacttccggttttactgggacctgatcatg
ctgctgctgatggtggggaacctcatcgtcctgcctgtgggcatcaccttcttcaaggag
gagaactccccgccttggatcgtcttcaacgtattgtctgatactttcttcctactggat
ctggtgctcaacttccgaacgggcatcgtggtggaggagggtgctgagatcctgctggca
ccgcgggccatccgcacgcgctacctgcgcacctggttcctggttgacctcatctcttct
atccctgtggattacatcttcctagtggtggagctggagccacggttggacgctgaggtc
tacaaaacggcacgggccctacgcatcgttcgcttcaccaagatcctaagcctgctgagg
ctgctccgcctctcccgcctcatccgctacatacaccagtgggaggagatctttcacatg
acctatgacctggccagtgctgtggttcgcatcttcaacctcattgggatgatgctgctg
ctatgtcactgggatggctgtctgcagttcctggtgcccatgctgcaggacttccctccc
gactgctgggtctccatcaaccacatggtgaaccactcgtggggccgccagtattcccat
gccctgttcaaggccatgagccacatgctgtgcattggctatgggcagcaggcacctgta
ggcatgcccgacgtctggctcaccatgctcagcatgatcgtaggtgccacatgctacgcc
atgttcatcggccatgccacggcactcatccagtccctggactcttcccggcgtcagtac
caggagaagtacaagcaggtggagcagtacatgtccttccacaagctgccagcagacacg
cggcagcgcatccacgagtactatgagcaccgctaccagggcaagatgttcgatgaggaa
agcatcctgggcgagctgagcgagccgcttcgcgaggagatcattaacttcacctgtcgg
ggcctggtggcccacatgccgctgtttgcccatgccgaccccagcttcgtcactgcagtt
ctcaccaagctgcgctttgaggtcttccagccgggggatctcgtggtgcgtgagggctcc
gtggggaggaagatgtacttcatccagcatgggctgctcagtgtgctggcccgcggcgcc
cgggacacacgcctcaccgatggatcctactttggggagatctgcctgctaactaggggc
cggcgcacagccagtgttcgggctgacacctactgccgcctttactcactcagcgtggac
catttcaatgctgtgcttgaggagttccccatgatgcgccgggcctttgagactgtggcc
atggatcggctgctccgcatcggcaagaagaattccatactgcagcggaagcgctccgag
ccaagtccaggcagcagtggtggcatcatggagcagcacttggtgcaacatgacagagac
atggctcggggtgttcggggtcgggccccgagcacaggagctcagcttagtggaaagcca
gtactgtgggagccactggtacatgcgccccttcaggcagctgctgtgacctccaatgtg
gccattgccctgactcatcagcggggccctctgcccctctcccctgactctccagccacc
ctccttgctcgctctgcttggcgctcagcaggctctccagcttccccgctggtgcccgtc
cgagctggcccatgggcatccacctcccgcctgcccgccccacctgcccgaaccctgcac
gccagcctatcccgggcagggcgctcccaggtctccctgctgggtccccctccaggagga
ggtggacggcggctaggacctcggggccgcccactctcagcctcccaaccctctctgcct
cagcgggcaacaggcgatggctctcctgggcgtaagggatcaggaagtgagcggctgcct
ccctcagggctcctggccaaacctccaaggacagcccagccccccaggccaccagtgcct
gagccagccacaccccggggtctccagctttctgccaacatgtaa
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