KEGG   NETWORK: N01905
Entry
N01905                      Network                                
Name
AC-PKA-HCN signaling
Definition
ADCY -> cAMP -> PKA -> PPP1R1B -| PP1 -| HCN
  Expanded
(107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) -> 84152 -| (5499+5500+5501) -| (348980,610,57657,10021)
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Gene
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
84152  PPP1R1B; protein phosphatase 1 regulatory inhibitor subunit 1B
5499  PPP1CA; protein phosphatase 1 catalytic subunit alpha
5500  PPP1CB; protein phosphatase 1 catalytic subunit beta
5501  PPP1CC; protein phosphatase 1 catalytic subunit gamma
348980  HCN1; hyperpolarization activated cyclic nucleotide gated potassium channel 1
610  HCN2; hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
57657  HCN3; hyperpolarization activated cyclic nucleotide gated potassium channel 3
10021  HCN4; hyperpolarization activated cyclic nucleotide gated potassium channel 4
Metabolite
C00575  3',5'-Cyclic AMP
Reference
PMID:26790349
  Authors
Xing B, Li YC, Gao WJ
  Title
Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex.
  Journal
Brain Res 1641:217-33 (2016)
DOI:10.1016/j.brainres.2016.01.005
Reference
PMID:21771489
  Authors
Gilsbach R, Albarran-Juarez J, Hein L
  Title
Pre- versus postsynaptic signaling by alpha(2)-adrenoceptors.
  Journal
Curr Top Membr 67:139-60 (2011)
DOI:10.1016/B978-0-12-384921-2.00007-0
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