Homo sapiens (human): 610
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Entry
610 CDS
T01001
Symbol
HCN2, BCNG-2, BCNG2, EIG17, FEB2, GEFSP11, HAC-1
Name
(RefSeq) hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
KO
K04955
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04024
cAMP signaling pathway
hsa04929
GnRH secretion
Network
nt06544
Neuroactive ligand signaling
Element
N01905
AC-PKA-HCN signaling
Disease
H00783
Febrile seizures
H02564
Generalized epilepsy with febrile seizures plus
Drug target
Ivabradine (
DG00246
):
D07165
D08095
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
610 (HCN2)
09150 Organismal Systems
09152 Endocrine system
04929 GnRH secretion
610 (HCN2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
610 (HCN2)
Ion channels [BR:
hsa04040
]
Voltage-gated cation channels
Cyclic nucleotide-gated channel (HCN)
610 (HCN2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ion_trans
Ion_trans_N
cNMP_binding
Ion_trans_2
Motif
Other DBs
NCBI-GeneID:
610
NCBI-ProteinID:
NP_001185
OMIM:
602781
HGNC:
4846
Ensembl:
ENSG00000099822
UniProt:
Q9UL51
Structure
PDB
PDBj
LinkDB
All DBs
Position
19:589881..617159
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AA seq
889 aa
AA seq
DB search
MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEA
LPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARG
PKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSL
RMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET
TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIP
VDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDL
ASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFK
AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY
KQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVA
SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMK
LSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRL
DRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPP
PQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP
PGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRP
ASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL
NT seq
2670 nt
NT seq
+upstream
nt +downstream
nt
atggacgcgcgcgggggcggcgggcggcccggggagagcccgggcgcgacccccgcgccg
gggccgccgccgccgccgccgcccgcgcccccccaacagcagccgccgccgccgccgccg
cccgcgccccccccgggccccgggcccgcgcccccccagcacccgccccgggccgaggcg
ttgcccccggaggcggcggatgagggcggcccgcggggccggctccgcagccgcgacagc
tcgtgcggccgccccggcaccccgggcgcggcgagcacggccaagggcagcccgaacggc
gagtgcgggcgcggcgagccgcagtgcagccccgcggggcccgagggcccggcgcggggg
cccaaggtgtcgttctcgtgccgcggggcggcctcggggcccgcgccggggccggggccg
gcggaggaggcgggcagcgaggaggcgggcccggcgggggagccgcgcggcagccaggcc
agcttcatgcagcgccagttcggcgcgctcctgcagccgggcgtcaacaagttctcgctg
cggatgttcggcagccagaaggccgtggagcgcgagcaggagcgcgtcaagtcggcgggg
gcctggatcatccacccgtacagcgacttcaggttctactgggacttcaccatgctgctg
ttcatggtgggaaacctcatcatcatcccagtgggcatcaccttcttcaaggatgagacc
actgccccgtggatcgtgttcaacgtggtctcggacaccttcttcctcatggacctggtg
ttgaacttccgcaccggcattgtgatcgaggacaacacggagatcatcctggaccccgag
aagatcaagaagaagtatctgcgcacgtggttcgtggtggacttcgtgtcctccatcccc
gtggactacatcttccttatcgtggagaagggcattgactccgaggtctacaagacggca
cgcgccctgcgcatcgtgcgcttcaccaagatcctcagcctcctgcggctgctgcgcctc
tcacgcctgatccgctacatccatcagtgggaggagatcttccacatgacctatgacctg
gccagcgcggtgatgaggatctgcaatctcatcagcatgatgctgctgctctgccactgg
gacggctgcctgcagttcctggtgcctatgctgcaggacttcccgcgcaactgctgggtg
tccatcaatggcatggtgaaccactcgtggagtgaactgtactccttcgcactcttcaag
gccatgagccacatgctgtgcatcgggtacggccggcaggcgcccgagagcatgacggac
atctggctgaccatgctcagcatgattgtgggtgccacctgctacgccatgttcatcggc
cacgccactgccctcatccagtcgctggactcctcgcggcgccagtaccaggagaagtac
aagcaggtggagcagtacatgtccttccacaagctgccagctgacttccgccagaagatc
cacgactactatgagcaccgttaccagggcaagatgtttgacgaggacagcatcctgggc
gagctcaacgggcccctgcgggaggagatcgtcaacttcaactgccggaagctggtggcc
tccatgccgctgttcgccaacgccgaccccaacttcgtcacggccatgctgaccaagctc
aagttcgaggtcttccagccgggtgactacatcatccgcgaaggcaccatcgggaagaag
atgtacttcatccagcacggcgtggtcagcgtgctcactaagggcaacaaggagatgaag
ctgtccgatggctcctacttcggggagatctgcctgctcacccggggccgccgcacggcg
agcgtgcgggctgacacctactgccgcctctattcgctgagcgtggacaacttcaacgag
gtgctggaggagtaccccatgatgcggcgcgccttcgagacggtggccatcgaccgcctg
gaccgcatcggcaagaagaattccatcctcctgcacaaggtgcagcatgacctcaactcg
ggcgtattcaacaaccaggagaacgccatcatccaggagatcgtcaagtacgaccgcgag
atggtgcagcaggccgagctgggtcagcgcgtgggcctcttcccgccgccgccgccgccg
ccgcaggtcacctcggccatcgccacgctgcagcaggcggcggccatgagcttctgcccg
caggtggcgcggccgctcgtggggccgctggcgctcggctcgccgcgcctcgtgcgccgc
ccgcccccggggcccgcacctgccgccgcctcacccgggcccccgccccccgccagcccc
ccgggcgcgcccgccagcccccgggcaccgcggacctcgccctacggcggcctgcccgcc
gccccccttgctgggcccgccctgcccgcgcgccgcctgagccgcgcgtcgcgcccactg
tccgcctcgcagccctcgctgcctcacggcgcccccggccccgcggcctccacacgcccg
gccagcagctccacaccgcgcttggggcccacgcccgctgcccgggccgccgcgcccagc
ccggaccgcagggactcggcctcacccggcgccgccggcggcctggacccccaggactcc
gcgcgctcgcgcctctcgtccaacttgtga
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