Homo sapiens (human): 64087
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Entry
64087 CDS
T01001
Symbol
MCCC2, MCCB, MCCCbeta
Name
(RefSeq) methylcrotonyl-CoA carboxylase subunit 2
KO
K01969
3-methylcrotonyl-CoA carboxylase beta subunit [EC:
6.4.1.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00280
Valine, leucine and isoleucine degradation
hsa01100
Metabolic pathways
Module
hsa_M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Network
nt06024
Valine, leucine and isoleucine degradation
Element
N00851
Leucine degradation
Disease
H00181
3-Methylcrotonylglycinuria
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
64087 (MCCC2)
Enzymes [BR:
hsa01000
]
6. Ligases
6.4 Forming carbon-carbon bonds
6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
6.4.1.4 methylcrotonoyl-CoA carboxylase
64087 (MCCC2)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Carboxyl_trans
ACCA
MdcE
Motif
Other DBs
NCBI-GeneID:
64087
NCBI-ProteinID:
NP_071415
OMIM:
609014
HGNC:
6937
Ensembl:
ENSG00000131844
UniProt:
Q9HCC0
A0A140VK29
Structure
PDB
PDBj
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All DBs
Position
5:71587340..71658706
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AA seq
563 aa
AA seq
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MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERV
EHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGII
TGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPR
QADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIF
LAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKL
DVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFA
RIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAK
DGAKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAAN
VLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLV
LGLSFSAALNAPIEKTDFGIFRM
NT seq
1692 nt
NT seq
+upstream
nt +downstream
nt
atgtgggccgtcctgaggttagccctgcggccgtgtgcccgcgcctctcccgccgggccg
cgcgcctatcacggggactcggtggcctcgctgggcacccagccggacttgggctctgcc
ctctaccaggagaactacaagcagatgaaagcactagtaaatcagctccatgaacgagtg
gagcatataaaactaggaggtggtgagaaagcccgagcacttcacatatcaagaggaaaa
ctattgcccagagaaagaattgacaatctcatagacccagggtctccatttctggaatta
tcccagtttgcaggttaccagttatatgacaatgaggaggtgccaggaggtggcattatt
acaggcattggaagagtatcaggagtagaatgcatgattattgccaatgatgccaccgtc
aaaggaggtgcctactacccagtgactgtgaaaaaacaattacgggcccaagaaattgcc
atgcaaaacaggctcccctgcatctacttagttgattcgggaggagcatacttacctcga
caagcagatgtgtttccagatcgagaccactttggccgtacattctataatcaggcaatt
atgtcttctaaaaatattgcacagatcgcagtggtcatgggctcctgcaccgcaggagga
gcctatgtgcctgccatggctgatgaaaacatcattgtacgcaagcagggtaccattttc
ttggcaggaccccccttggttaaagcggcaactggggaagaagtatctgctgaggatctt
ggaggtgctgatcttcattgcagaaagtctggagtaagtgaccactgggctttggatgat
catcatgcccttcacttaactaggaaggttgtgaggaatctaaattatcagaagaaattg
gatgtcaccattgaaccttctgaagagcctttatttcctgctgatgaattgtatggaata
gttggtgctaaccttaagaggagctttgatgtccgagaggtcattgctagaatcgtggat
ggaagcagattcactgagttcaaagccttttatggagacacattagttacaggatttgct
cgaatatttgggtacccagtaggtatcgttggaaacaacggagttctcttttctgaatct
gcaaaaaagggtactcactttgtccagttatgctgccaaagaaatattcctctgctgttc
cttcaaaacattactggatttatggttggtagagagtatgaagctgaaggaattgccaag
gatggtgccaagatggtggccgctgtggcctgtgcccaagtgcctaagataaccctcatc
attgggggctcctatggagccggaaactatgggatgtgtggcagagcatatagcccaaga
tttctctacatttggccaaatgctcgtatctcagtgatgggaggagagcaggcagccaat
gtgttggccacgataacaaaggaccaaagagcccgggaaggaaagcagttctccagtgct
gatgaagcggctttaaaagagcccatcattaagaagtttgaagaggaaggaaacccttac
tattccagcgcaagggtatgggatgatgggatcattgatccagcagacaccagactggtc
ttgggtctcagttttagtgcagccctcaacgcaccaatagagaagactgacttcggtatc
ttcaggatgtaa
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