KEGG   Homo sapiens (human): 6469
Entry
6469              CDS       T01001                                 
Symbol
SHH, HHG1, HLP3, HPE3, MCOPCB5, SMMCI, ShhNC, TPT, TPTPS
Name
(RefSeq) sonic hedgehog signaling molecule
  KO
K11988  sonic hedgehog
Organism
hsa  Homo sapiens (human)
Pathway
hsa04340  Hedgehog signaling pathway
hsa04360  Axon guidance
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05217  Basal cell carcinoma
hsa05226  Gastric cancer
Network
nt06217  HH signaling (cancer)
nt06240  Transcription (cancer)
nt06261  Gastric cancer
nt06269  Basal cell carcinoma
nt06501  HH signaling
  Element
N00062  Hedgehog signaling pathway
N00251  CDX2-overexpression to transcriptional repression
N01537  Hedgehog signaling pathway, HH ligand secretion
N01538  Hedgehog signaling pathway, PTCH coreceptor
Disease
H00267  Holoprosencephaly
H00652  Solitary median maxillary central incisor syndrome
H01027  Microphthalmia
H01160  Schizencephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    6469 (SHH)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    6469 (SHH)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6469 (SHH)
   05205 Proteoglycans in cancer
    6469 (SHH)
  09162 Cancer: specific types
   05226 Gastric cancer
    6469 (SHH)
   05217 Basal cell carcinoma
    6469 (SHH)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    6469 (SHH)
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    6469 (SHH)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C46: hedgehog family
   6469 (SHH)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Morphogens
   6469 (SHH)
SSDB
Motif
Pfam: HH_signal Hint Peptidase_M15_3 Ribosomal_S6e
Other DBs
NCBI-GeneID: 6469
NCBI-ProteinID: NP_000184
OMIM: 600725
HGNC: 10848
Ensembl: ENSG00000164690
UniProt: Q15465
Structure
LinkDB
Position
7:complement(155799980..155812463)
AA seq 462 aa
MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASG
RYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGV
KLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAH
IHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLT
FLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALG
PRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVL
ASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGA
ADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS
NT seq 1389 nt   +upstreamnt  +downstreamnt
atgctgctgctggcgagatgtctgctgctagtcctcgtctcctcgctgctggtatgctcg
ggactggcgtgcggaccgggcagggggttcgggaagaggaggcaccccaaaaagctgacc
cctttagcctacaagcagtttatccccaatgtggccgagaagaccctaggcgccagcgga
aggtatgaagggaagatctccagaaactccgagcgatttaaggaactcacccccaattac
aaccccgacatcatatttaaggatgaagaaaacaccggagcggacaggctgatgactcag
aggtgtaaggacaagttgaacgctttggccatctcggtgatgaaccagtggccaggagtg
aaactgcgggtgaccgagggctgggacgaagatggccaccactcagaggagtctctgcac
tacgagggccgcgcagtggacatcaccacgtctgaccgcgaccgcagcaagtacggcatg
ctggcccgcctggcggtggaggccggcttcgactgggtgtactacgagtccaaggcacat
atccactgctcggtgaaagcagagaactcggtggcggccaaatcgggaggctgcttcccg
ggctcggccacggtgcacctggagcagggcggcaccaagctggtgaaggacctgagcccc
ggggaccgcgtgctggcggcggacgaccagggccggctgctctacagcgacttcctcact
ttcctggaccgcgacgacggcgccaagaaggtcttctacgtgatcgagacgcgggagccg
cgcgagcgcctgctgctcaccgccgcgcacctgctctttgtggcgccgcacaacgactcg
gccaccggggagcccgaggcgtcctcgggctcggggccgccttccgggggcgcactgggg
cctcgggcgctgttcgccagccgcgtgcgcccgggccagcgcgtgtacgtggtggccgag
cgtgacggggaccgccggctcctgcccgccgctgtgcacagcgtgaccctaagcgaggag
gccgcgggcgcctacgcgccgctcacggcccagggcaccattctcatcaaccgggtgctg
gcctcgtgctacgcggtcatcgaggagcacagctgggcgcaccgggccttcgcgcccttc
cgcctggcgcacgcgctcctggctgcactggcgcccgcgcgcacggaccgcggcggggac
agcggcggcggggaccgcgggggcggcggcggcagagtagccctaaccgctccaggtgct
gccgacgctccgggtgcgggggccaccgcgggcatccactggtactcgcagctgctctac
caaataggcacctggctcctggacagcgaggccctgcacccgctgggcatggcggtcaag
tccagctga

KEGG   Homo sapiens (human): 3549
Entry
3549              CDS       T01001                                 
Symbol
IHH, BDA1, HHG2
Name
(RefSeq) Indian hedgehog signaling molecule
  KO
K11989  indian hedgehog
Organism
hsa  Homo sapiens (human)
Pathway
hsa04340  Hedgehog signaling pathway
hsa05205  Proteoglycans in cancer
Network
nt06217  HH signaling (cancer)
nt06269  Basal cell carcinoma
nt06501  HH signaling
  Element
N00062  Hedgehog signaling pathway
N01537  Hedgehog signaling pathway, HH ligand secretion
N01538  Hedgehog signaling pathway, PTCH coreceptor
Disease
H00482  Brachydactyly
H00675  Acrocapitofemoral dysplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    3549 (IHH)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    3549 (IHH)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    3549 (IHH)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C46: hedgehog family
   3549 (IHH)
SSDB
Motif
Pfam: HH_signal Hint Peptidase_M15_3
Other DBs
NCBI-GeneID: 3549
NCBI-ProteinID: NP_002172
OMIM: 600726
HGNC: 5956
Ensembl: ENSG00000163501
UniProt: Q14623
Structure
LinkDB
Position
2:complement(219054424..219060921)
AA seq 411 aa
MSPARLRPRLHFCLVLLLLLVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKT
LGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMN
QWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYY
ESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTF
SDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQP
GQYVLVAGVPGLQPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLA
FWPLRLFHSLAWGSWTPGEGVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS
NT seq 1236 nt   +upstreamnt  +downstreamnt
atgtctcccgcccggctccggccccgactgcacttctgcctggtcctgttgctgctgctg
gtggtgccggcggcatggggctgcgggccgggtcgggtggtgggcagccgccggcgaccg
ccacgcaaactcgtgccgctcgcctacaagcagttcagccccaatgtgcccgagaagacc
ctgggcgccagcggacgctatgaaggcaagatcgctcgcagctccgagcgcttcaaggag
ctcacccccaattacaatccagacatcatcttcaaggacgaggagaacacaggcgccgac
cgcctcatgacccagcgctgcaaggaccgcctgaactcgctggctatctcggtgatgaac
cagtggcccggtgtgaagctgcgggtgaccgagggctgggacgaggacggccaccactca
gaggagtccctgcattatgagggccgcgcggtggacatcaccacatcagaccgcgaccgc
aataagtatggactgctggcgcgcttggcagtggaggccggctttgactgggtgtattac
gagtcaaaggcccacgtgcattgctccgtcaagtccgagcactcggccgcagccaagacg
ggcggctgcttccctgccggagcccaggtacgcctggagagtggggcgcgtgtggccttg
tcagccgtgaggccgggagaccgtgtgctggccatgggggaggatgggagccccaccttc
agcgatgtgctcattttcctggaccgcgagcctcacaggctgagagccttccaggtcatc
gagactcaggaccccccacgccgcctggcactcacacccgctcacctgctctttacggct
gacaatcacacggagccggcagcccgcttccgggccacatttgccagccacgtgcagcct
ggccagtacgtgctggtggctggggtgccaggcctgcagcctgcccgcgtggcagctgtc
tctacacacgtggccctcggggcctacgccccgctcacaaagcatgggacactggtggtg
gaggatgtggtggcatcctgcttcgcggccgtggctgaccaccacctggctcagttggcc
ttctggcccctgagactctttcacagcttggcatggggcagctggactccgggggagggt
gtgcattggtacccccagctgctctaccgcctggggcgtctcctgctagaagagggcagc
ttccacccactgggcatgtccggggcagggagctga

KEGG   Homo sapiens (human): 50846
Entry
50846             CDS       T01001                                 
Symbol
DHH, GDMN, GDXYM, HHG-3, SRXY7
Name
(RefSeq) desert hedgehog signaling molecule
  KO
K11990  desert hedgehog
Organism
hsa  Homo sapiens (human)
Pathway
hsa04340  Hedgehog signaling pathway
Network
nt06217  HH signaling (cancer)
nt06269  Basal cell carcinoma
nt06501  HH signaling
  Element
N00062  Hedgehog signaling pathway
N01537  Hedgehog signaling pathway, HH ligand secretion
N01538  Hedgehog signaling pathway, PTCH coreceptor
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    50846 (DHH)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    50846 (DHH)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C46: hedgehog family
   50846 (DHH)
SSDB
Motif
Pfam: HH_signal Hint Peptidase_M15_3 Vint
Other DBs
NCBI-GeneID: 50846
NCBI-ProteinID: NP_066382
OMIM: 605423
HGNC: 2865
Ensembl: ENSG00000139549
UniProt: O43323
Structure
LinkDB
Position
12:complement(49086656..49094801)
AA seq 396 aa
MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGAS
GPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPG
VRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRN
HVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVL
LFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSV
LAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPL
RLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG
NT seq 1191 nt   +upstreamnt  +downstreamnt
atggctctcctgaccaatctactgcccctgtgctgcttggcacttctggcgctgccagcc
cagagctgcgggccgggccgggggccggttggccggcgccgctatgcgcgcaagcagctc
gtgccgctactctacaagcaatttgtgcccggcgtgccagagcggaccctgggcgccagt
gggccagcggaggggagggtggcaaggggctccgagcgcttccgggacctcgtgcccaac
tacaaccccgacatcatcttcaaggatgaggagaacagtggagccgaccgcctgatgacc
gagcgttgtaaggagcgggtgaacgctttggccattgccgtgatgaacatgtggcccgga
gtgcgcctacgagtgactgagggctgggacgaggacggccaccacgctcaggattcactc
cactacgaaggccgtgctttggacatcactacgtctgaccgcgaccgcaacaagtatggg
ttgctggcgcgcctcgcagtggaagccggcttcgactgggtctactacgagtcccgcaac
cacgtccacgtgtcggtcaaagctgataactcactggcggtccgggcgggcggctgcttt
ccgggaaatgcaactgtgcgcctgtggagcggcgagcggaaagggctgcgggaactgcac
cgcggagactgggttttggcggccgatgcgtcaggccgggtggtgcccacgccggtgctg
ctcttcctggaccgggacttgcagcgccgggcttcatttgtggctgtggagaccgagtgg
cctccacgcaaactgttgctcacgccctggcacctggtgtttgccgctcgagggccggcg
cccgcgccaggcgactttgcaccggtgttcgcgcgccggctacgcgctggggactcggtg
ctggcgcccggcggggatgcgcttcggccagcgcgcgtggcccgtgtggcgcgggaggaa
gccgtgggcgtgttcgcgccgctcaccgcgcacgggacgctgctggtgaacgatgtcctg
gcctcttgctacgcggttctggagagtcaccagtgggcgcaccgcgcttttgcccccttg
agactgctgcacgcgctaggggcgctgctccccggcggggccgtccagccgactggcatg
cattggtactctcggctcctctaccgcttagcggaggagctactgggctga

KEGG   Homo sapiens (human): 5727
Entry
5727              CDS       T01001                                 
Symbol
PTCH1, BCNS, BCNS1, NBCCS, PTC, PTC1, PTCH
Name
(RefSeq) patched 1
  KO
K06225  patched 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04340  Hedgehog signaling pathway
hsa04360  Axon guidance
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05217  Basal cell carcinoma
Network
nt06217  HH signaling (cancer)
nt06269  Basal cell carcinoma
nt06501  HH signaling
  Element
N00010  Mutation-inactivated PTCH1 to Hedgehog signaling pathway
N00017  Mutation-activated SMO to Hedgehog signaling pathway
N00062  Hedgehog signaling pathway
N01538  Hedgehog signaling pathway, PTCH coreceptor
Disease
H00039  Basal cell carcinoma
H00267  Holoprosencephaly
H00895  Basal cell nevus syndrome
H01667  Medulloblastoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    5727 (PTCH1)
   04024 cAMP signaling pathway
    5727 (PTCH1)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    5727 (PTCH1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5727 (PTCH1)
   05205 Proteoglycans in cancer
    5727 (PTCH1)
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    5727 (PTCH1)
SSDB
Motif
Pfam: Patched Sterol-sensing
Other DBs
NCBI-GeneID: 5727
NCBI-ProteinID: NP_000255
OMIM: 601309
HGNC: 9585
Ensembl: ENSG00000185920
UniProt: Q13635
Structure
LinkDB
Position
9:complement(95442980..95516971)
AA seq 1447 aa
MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAF
ALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAAN
LETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLD
SALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAK
LQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPA
DPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHAL
QTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVL
SFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALS
VAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGEC
LKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDL
YRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQS
TVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSL
HCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDI
VPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQL
PKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDIS
QLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETR
LRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQ
YIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSA
VPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLML
AGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEP
PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATE
NPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRR
DAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVA
VHPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEER
PRGSSSN
NT seq 4344 nt   +upstreamnt  +downstreamnt
atggcctcggctggtaacgccgccgagccccaggaccgcggcggcggcggcagcggctgt
atcggtgccccgggacggccggctggaggcgggaggcgcagacggacgggggggctgcgc
cgtgctgccgcgccggaccgggactatctgcaccggcccagctactgcgacgccgccttc
gctctggagcagatttccaaggggaaggctactggccggaaagcgccgctgtggctgaga
gcgaagtttcagagactcttatttaaactgggttgttacattcaaaaaaactgcggcaag
ttcttggttgtgggcctcctcatatttggggccttcgcggtgggattaaaagcagcgaac
ctcgagaccaacgtggaggagctgtgggtggaagttggaggacgagtaagtcgtgaatta
aattatactcgccagaagattggagaagaggctatgtttaatcctcaactcatgatacag
acccctaaagaagaaggtgctaatgtcctgaccacagaagcgctcctacaacacctggac
tcggcactccaggccagccgtgtccatgtatacatgtacaacaggcagtggaaattggaa
catttgtgttacaaatcaggagagcttatcacagaaacaggttacatggatcagataata
gaatatctttacccttgtttgattattacacctttggactgcttctgggaaggggcgaaa
ttacagtctgggacagcatacctcctaggtaaacctcctttgcggtggacaaacttcgac
cctttggaattcctggaagagttaaagaaaataaactatcaagtggacagctgggaggaa
atgctgaataaggctgaggttggtcatggttacatggaccgcccctgcctcaatccggcc
gatccagactgccccgccacagcccccaacaaaaattcaaccaaacctcttgatatggcc
cttgttttgaatggtggatgtcatggcttatccagaaagtatatgcactggcaggaggag
ttgattgtgggtggcacagtcaagaacagcactggaaaactcgtcagcgcccatgccctg
cagaccatgttccagttaatgactcccaagcaaatgtacgagcacttcaaggggtacgag
tatgtctcacacatcaactggaacgaggacaaagcggcagccatcctggaggcctggcag
aggacatatgtggaggtggttcatcagagtgtcgcacagaactccactcaaaaggtgctt
tccttcaccaccacgaccctggacgacatcctgaaatccttctctgacgtcagtgtcatc
cgcgtggccagcggctacttactcatgctcgcctatgcctgtctaaccatgctgcgctgg
gactgctccaagtcccagggtgccgtggggctggctggcgtcctgctggttgcactgtca
gtggctgcaggactgggcctgtgctcattgatcggaatttcctttaacgctgcaacaact
caggttttgccatttctcgctcttggtgttggtgtggatgatgtttttcttctggcccac
gccttcagtgaaacaggacagaataaaagaatcccttttgaggacaggaccggggagtgc
ctgaagcgcacaggagccagcgtggccctcacgtccatcagcaatgtcacagccttcttc
atggccgcgttaatcccaattcccgctctgcgggcgttctccctccaggcagcggtagta
gtggtgttcaattttgccatggttctgctcatttttcctgcaattctcagcatggattta
tatcgacgcgaggacaggagactggatattttctgctgttttacaagcccctgcgtcagc
agagtgattcaggttgaacctcaggcctacaccgacacacacgacaatacccgctacagc
cccccacctccctacagcagccacagctttgcccatgaaacgcagattaccatgcagtcc
actgtccagctccgcacggagtacgacccccacacgcacgtgtactacaccaccgctgag
ccgcgctccgagatctctgtgcagcccgtcaccgtgacacaggacaccctcagctgccag
agcccagagagcaccagctccacaagggacctgctctcccagttctccgactccagcctc
cactgcctcgagcccccctgtacgaagtggacactctcatcttttgctgagaagcactat
gctcctttcctcttgaaaccaaaagccaaggtagtggtgatcttcctttttctgggcttg
ctgggggtcagcctttatggcaccacccgagtgagagacgggctggaccttacggacatt
gtacctcgggaaaccagagaatatgactttattgctgcacaattcaaatacttttctttc
tacaacatgtatatagtcacccagaaagcagactacccgaatatccagcacttactttac
gacctacacaggagtttcagtaacgtgaagtatgtcatgttggaagaaaacaaacagctt
cccaaaatgtggctgcactacttcagagactggcttcagggacttcaggatgcatttgac
agtgactgggaaaccgggaaaatcatgccaaacaattacaagaatggatcagacgatgga
gtccttgcctacaaactcctggtgcaaaccggcagccgcgataagcccatcgacatcagc
cagttgactaaacagcgtctggtggatgcagatggcatcattaatcccagcgctttctac
atctacctgacggcttgggtcagcaacgaccccgtcgcgtatgctgcctcccaggccaac
atccggccacaccgaccagaatgggtccacgacaaagccgactacatgcctgaaacaagg
ctgagaatcccggcagcagagcccatcgagtatgcccagttccctttctacctcaacggc
ttgcgggacacctcagactttgtggaggcaattgaaaaagtaaggaccatctgcagcaac
tatacgagcctggggctgtccagttaccccaacggctaccccttcctcttctgggagcag
tacatcggcctccgccactggctgctgctgttcatcagcgtggtgttggcctgcacattc
ctcgtgtgcgctgtcttccttctgaacccctggacggccgggatcattgtgatggtcctg
gcgctgatgacggtcgagctgttcggcatgatgggcctcatcggaatcaagctcagtgcc
gtgcccgtggtcatcctgatcgcttctgttggcataggagtggagttcaccgttcacgtt
gctttggcctttctgacggccatcggcgacaagaaccgcagggctgtgcttgccctggag
cacatgtttgcacccgtcctggatggcgccgtgtccactctgctgggagtgctgatgctg
gcgggatctgagttcgacttcattgtcaggtatttctttgctgtgctggcgatcctcacc
atcctcggcgttctcaatgggctggttttgcttcccgtgcttttgtctttctttggacca
tatcctgaggtgtctccagccaacggcttgaaccgcctgcccacaccctcccctgagcca
ccccccagcgtggtccgcttcgccatgccgcccggccacacgcacagcgggtctgattcc
tccgactcggagtatagttcccagacgacagtgtcaggcctcagcgaggagcttcggcac
tacgaggcccagcagggcgcgggaggccctgcccaccaagtgatcgtggaagccacagaa
aaccccgtcttcgcccactccactgtggtccatcccgaatccaggcatcacccaccctcg
aacccgagacagcagccccacctggactcagggtccctgcctcccggacggcaaggccag
cagccccgcagggacccccccagagaaggcttgtggccacccccctacagaccgcgcaga
gacgcttttgaaatttctactgaagggcattctggccctagcaatagggcccgctggggc
cctcgcggggcccgttctcacaaccctcggaacccagcgtccactgccatgggcagctcc
gtgcccggctactgccagcccatcaccactgtgacggcttctgcctccgtgactgtcgcc
gtgcacccgccgcctgtccctgggcctgggcggaacccccgagggggactctgcccaggc
taccctgagactgaccacggcctgtttgaggacccccacgtgcctttccacgtccggtgt
gagaggagggattcgaaggtggaagtcattgagctgcaggacgtggaatgcgaggagagg
ccccggggaagcagctccaactga

KEGG   Homo sapiens (human): 8643
Entry
8643              CDS       T01001                                 
Symbol
PTCH2, PTC2
Name
(RefSeq) patched 2
  KO
K11101  patched 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04340  Hedgehog signaling pathway
hsa05200  Pathways in cancer
hsa05217  Basal cell carcinoma
Network
nt06217  HH signaling (cancer)
nt06269  Basal cell carcinoma
nt06501  HH signaling
  Element
N00010  Mutation-inactivated PTCH1 to Hedgehog signaling pathway
N00017  Mutation-activated SMO to Hedgehog signaling pathway
N00062  Hedgehog signaling pathway
N01538  Hedgehog signaling pathway, PTCH coreceptor
Disease
H00039  Basal cell carcinoma
H01667  Medulloblastoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    8643 (PTCH2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    8643 (PTCH2)
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    8643 (PTCH2)
SSDB
Motif
Pfam: Patched Sterol-sensing
Other DBs
NCBI-GeneID: 8643
NCBI-ProteinID: NP_003729
OMIM: 603673
HGNC: 9586
Ensembl: ENSG00000117425
UniProt: Q9Y6C5
LinkDB
Position
1:complement(44819845..44843253)
AA seq 1203 aa
MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLF
LGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTAR
QEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKL
FPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDK
AQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLG
GMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFV
QLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQ
SQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTE
ALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFV
AVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATV
QAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKS
LPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRG
TKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRT
WLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLT
TRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIP
PAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGL
RRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVV
ILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSH
FDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGG
LRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGP
ATG
NT seq 3612 nt   +upstreamnt  +downstreamnt
atgactcgatcgccgcccctcagagagctgcccccgagttacacacccccagctcgaacc
gcagcaccccagatcctagctgggagcctgaaggctccactctggcttcgtgcttacttc
cagggcctgctcttctctctgggatgcgggatccagagacattgtggcaaagtgctcttt
ctgggactgttggcctttggggccctggcattaggtctccgcatggccattattgagaca
aacttggaacagctctgggtagaagtgggcagccgggtgagccaggagctgcattacacc
aaggagaagctgggggaggaggctgcatacacctctcagatgctgatacagaccgcacgc
caggagggagagaacatcctcacacccgaagcacttggcctccacctccaggcagccctc
actgccagtaaagtccaagtatcactctatgggaagtcctgggatttgaacaaaatctgc
tacaagtcaggagttccccttattgaaaatggaatgattgagcggatgattgagaagctg
tttccgtgcgtgatcctcacccccctcgactgcttctgggagggagccaaactccaaggg
ggctccgcctacctgcccggccgcccggatatccagtggaccaacctggatccagagcag
ctgctggaggagctgggtccctttgcctcccttgagggcttccgggagctgctagacaag
gcacaggtgggccaggcctacgtggggcggccctgtctgcaccctgatgacctccactgc
ccacctagtgcccccaaccatcacagcaggcaggctcccaatgtggctcacgagctgagt
gggggctgccatggcttctcccacaaattcatgcactggcaggaggaattgctgctggga
ggcatggccagagacccccaaggagagctgctgagggcagaggccctgcagagcaccttc
ttgctgatgagtccccgccagctgtacgagcatttccggggtgactatcagacacatgac
attggctggagtgaggagcaggccagcacagtgctacaagcctggcagcggcgctttgtg
cagctggcccaggaggccctgcctgagaacgcttcccagcagatccatgccttctcctcc
accaccctggatgacatcctgcatgcgttctctgaagtcagtgctgcccgtgtggtggga
ggctatctgctcatgctggcctatgcctgtgtgaccatgctgcggtgggactgcgcccag
tcccagggttccgtgggccttgccggggtactgctggtggccctggcggtggcctcaggc
cttgggctctgtgccctgctcggcatcaccttcaatgctgccactacccaggtgctgccc
ttcttggctctgggaatcggcgtggatgacgtattcctgctggcgcatgccttcacagag
gctctgcctggcacccctctccaggagcgcatgggcgagtgtctgcagcgcacgggcacc
agtgtcgtactcacatccatcaacaacatggccgccttcctcatggctgccctcgttccc
atccctgcgctgcgagccttctccctacaggcggccatagtggttggctgcacctttgta
gccgtgatgcttgtcttcccagccatcctcagcctggacctacggcggcgccactgccag
cgccttgatgtgctctgctgcttctccagtccctgctctgctcaggtgattcagatcctg
ccccaggagctgggggacgggacagtaccagtgggcattgcccacctcactgccacagtt
caagcctttacccactgtgaagccagcagccagcatgtggtcaccatcctgcctccccaa
gcccacctggtgcccccaccttctgacccactgggctctgagctcttcagccctggaggg
tccacacgggaccttctaggccaggaggaggagacaaggcagaaggcagcctgcaagtcc
ctgccctgtgcccgctggaatcttgcccatttcgcccgctatcagtttgccccgttgctg
ctccagtcacatgctaaggccatcgtgctggtgctctttggtgctcttctgggcctgagc
ctctacggagccaccttggtgcaagacggcctggccctgacggatgtggtgcctcggggc
accaaggagcatgccttcctgagcgcccagctcaggtacttctccctgtacgaggtggcc
ctggtgacccagggtggctttgactacgcccactcccaacgcgccctctttgatctgcac
cagcgcttcagttccctcaaggcggtgctgcccccaccggccacccaggcaccccgcacc
tggctgcactattaccgcaactggctacagggaatccaggctgcctttgaccaggactgg
gcttctgggcgcatcacccgccactcgtaccgcaatggctctgaggatggggccctggcc
tacaagctgctcatccagactggagacgcccaggagcctctggatttcagccagctgacc
acaaggaagctggtggacagagagggactgattccacccgagctcttctacatggggctg
accgtgtgggtgagcagtgaccccctgggtctggcagcctcacaggccaacttctacccc
ccacctcctgaatggctgcacgacaaatacgacaccacgggggagaaccttcgcatcccg
ccagctcagcccttggagtttgcccagttccccttcctgctgcgtggcctccagaagact
gcagactttgtggaggccatcgagggggcccgggcagcatgcgcagaggccggccaggct
ggggtgcacgcctaccccagcggctcccccttcctcttctgggaacagtatctgggcctg
cggcgctgcttcctgctggccgtctgcatcctgctggtgtgcactttcctcgtctgtgct
ctgctgctcctcaacccctggacggctggcctcatagtgctggtcctggcgatgatgaca
gtggaactctttggtatcatgggtttcctgggcatcaagctgagtgccatccccgtggtg
atccttgtggcctctgtaggcattggcgttgagttcacagtccacgtggctctgggcttc
ctgaccacccagggcagccggaacctgcgggccgcccatgcccttgagcacacatttgcc
cccgtgaccgatggggccatctccacattgctgggtctgctcatgcttgctggttcccac
tttgacttcattgtaaggtacttctttgcggcgctgacagtgctcacgctcctgggcctc
ctccatggactcgtgctgctgcctgtgctgctgtccatcctgggcccgccgccagaggtg
atacagatgtacaaggaaagcccagagatcctgagtccaccagctccacagggaggcggg
cttaggtggggggcatcctcctccctgccccagagctttgccagagtgactacctccatg
accgtggccatccacccaccccccctgcctggtgcctacatccatccagcccctgatgag
cccccttggtcccctgctgccactagctctggcaacctcagttccaggggaccaggtcca
gccactgggtga

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