KEGG T01001: 6573

Homo sapiens (human): 6573

Entry

6573              CDS       T01001

Symbol

SLC19A1, CHMD, FOLT, IFC-1, IFC1, IMD114, MEGAF, REFC, RFC, RFC1, RFT-1, hRFC, hSLC19A1

Name

(RefSeq) reduced folate transporter isoform 1

K14609

solute carrier family 19 (folate transporter), member 1

Organism

hsa Homo sapiens (human)

Pathway

hsa01523

Antifolate resistance

hsa04977

Vitamin digestion and absorption

hsa04981

Folate transport and metabolism

hsa05215

Prostate cancer

Disease

H01725

Primary immunodeficiency disease

H02699

Folate-responsive megaloblastic anemia

Brite

KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
  09154 Digestive system
   04977 Vitamin digestion and absorption
    6573 (SLC19A1)
   04981 Folate transport and metabolism
    6573 (SLC19A1)
09160 Human Diseases
  09162 Cancer: specific types
   05215 Prostate cancer
    6573 (SLC19A1)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    6573 (SLC19A1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6573 (SLC19A1)
Transporters [BR:hsa02000]
Solute carrier family (SLC)
  SLC19: Folate/thiamine transporter
   6573 (SLC19A1)

SSDB

Motif

Pfam:

Folate_carrier MFS_1 DUF6767

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

UniProt:

Structure

LinkDB

Position

21:complement(45502517..45563025)

AA seq 591 aa
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT
REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ
LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV
SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH
ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS
SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD
VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV
TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ

NT seq 1776 nt +upstreamnt +downstreamnt
atggtgccctccagcccagcggtggagaagcaggtgcccgtggaacctgggcctgacccc
gagctccggtcctggcggcacctcgtgtgctacctttgcttctacggcttcatggcgcag
atacggccaggggagagcttcatcaccccctacctcctggggcccgacaagaacttcacg
cgggagcaggtcacgaacgagatcacgccggtgctgtcgtactcctacctggccgtgctg
gtgcccgtgttcctgctcaccgactacctgcgctacacgccggtgctgctgctgcagggg
ctcagcttcgtgtcggtgtggctgctgctgctgctgggccactcggtggcgcacatgcag
ctcatggagctcttctacagcgtcaccatggccgcgcgcatcgcctattcctcctacatc
ttctctctcgtgcggcccgcgcgctaccagcgtgtggccggctactcgcgcgctgcggtg
ctgctgggcgtgttcaccagctccgtgctgggccagctgctggtcactgtgggccgagtc
tccttctccacgctcaactacatctcgctggccttcctcaccttcagcgtggtcctcgcc
ctcttcctgaagcgccccaagcgcagcctcttcttcaaccgcgacgaccgggggcggtgc
gaaacctcggcttcggagctggagcgcatgaatcctggcccaggcgggaagctgggacac
gccctgcgggtggcctgtggggactcagtgctggcgcggatgctgcgggagctgggggac
agcctgcggcggccgcagctgcgcctgtggtccctctggtgggtcttcaactcggccggc
tactacctggtggtctactacgtgcacatcctgtggaacgaggtggaccccaccaccaac
agtgcgcgggtctacaacggcgcggcagatgctgcctccacgctgctgggcgccatcacg
tccttcgccgcgggcttcgtgaagatccgctgggcgcgctggtccaagctgctcatcgcg
ggcgtcacggccacgcaggcggggctggtcttccttctggcgcacacgcgccacccgagc
agcatctggctgtgctatgcggccttcgtgctgttccgcggctcctaccagttcctcgtg
cccatcgccacctttcagattgcatcttctctgtctaaagagctctgtgccctggtcttc
ggggtcaacacgttctttgccaccatcgtcaagaccatcatcactttcattgtctcggac
gtgcggggcctgggcctcccggtccgcaagcagttccagttatactccgtgtacttcctg
atcctgtccatcatctacttcttgggggccatgctggatggcctgcggcactgccagcgg
ggccaccacccgcggcagcccccggcccagggcctgaggagtgccgcggaggagaaggca
gcacaggcactgagcgtgcaggacaagggcctcggaggcctgcagccagcccagagcccg
ccgctttccccagaagacagcctgggggctgtggggccagcctccctggagcagagacag
agcgacccatacctggcccaggccccggccccgcaggcagctgaattcctgagcccagtg
acaaccccttccccctgcactctgtgctccgcccaagcctcaggccctgaggctgcagat
gagacttgtccccagctggctgtccatcctcctggtgtcagcaagctgggtttgcagtgt
cttccaagcgacggtgttcagaatgtgaaccagtga

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