Homo sapiens (human): 6646
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Entry
6646 CDS
T01001
Symbol
SOAT1, ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT
Name
(RefSeq) sterol O-acyltransferase 1
KO
K00637
sterol O-acyltransferase [EC:
2.3.1.26
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00100
Steroid biosynthesis
hsa04979
Cholesterol metabolism
Drug target
Avasimibe:
D03012
Cetaben sodium:
D03447
Eldacimibe:
D03734
Lecimibide:
D03735
Melinamide:
D01202
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00100 Steroid biosynthesis
6646 (SOAT1)
09150 Organismal Systems
09154 Digestive system
04979 Cholesterol metabolism
6646 (SOAT1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.26 sterol O-acyltransferase
6646 (SOAT1)
BRITE hierarchy
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MBOAT
Motif
Other DBs
NCBI-GeneID:
6646
NCBI-ProteinID:
NP_003092
OMIM:
102642
HGNC:
11177
Ensembl:
ENSG00000057252
UniProt:
P35610
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:179293797..179358680
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AA seq
550 aa
AA seq
DB search
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
NT seq
1653 nt
NT seq
+upstream
nt +downstream
nt
atggtgggtgaagagaagatgtctctaagaaaccggctgtcaaagtccagggaaaatcct
gaggaagatgaagaccagagaaaccctgcaaaggagtccctagagacacctagtaatggt
cgaattgacataaaacagttgatagcaaagaagataaagttgacagcagaggcagaggaa
ttgaagccattttttatgaaggaagttggcagtcactttgatgattttgtgaccaatctc
attgaaaagtcagcatcattagataatggtgggtgcgctctcacaaccttttctgttctt
gaaggagagaaaaacaaccatagagcgaaggatttgagagcacctccagaacaaggaaag
atttttattgcaaggcgctctctcttagatgaactgcttgaagtggaccacatcagaaca
atatatcacatgtttattgccctcctcattctctttatcctcagcacacttgtagtagat
tacattgatgaaggaaggctggtgcttgagttcagcctcctgtcttatgcttttggcaaa
tttcctaccgttgtttggacctggtggatcatgttcctgtctacattttcagttccctat
tttctgtttcaacattgggccactggctatagcaagagttctcatccgctgatccgttct
ctcttccatggctttcttttcatgatcttccagattggagttctaggttttggaccaaca
tatgttgtgttagcatatacactgccaccagcttcccggttcatcattatattcgagcag
attcgttttgtaatgaaggcccactcatttgtcagagagaacgtgcctcgggtactaaat
tcagctaaggagaaatcaagcactgttccaatacctacagtcaaccagtatttgtacttc
ttatttgctcctacccttatctaccgtgacagctatcccaggaatcccactgtaagatgg
ggttatgtcgctatgaagtttgcacaggtctttggttgctttttctatgtgtactacatc
tttgaaaggctttgtgcccccttgtttcggaatatcaaacaggagcccttcagcgctcgt
gttctggtcctatgtgtatttaactccatcttgccaggtgtgctgattctcttccttact
ttttttgcctttttgcactgctggctcaatgcctttgctgagatgttacgctttggtgac
aggatgttctataaggattggtggaactccacgtcatactccaactattatagaacctgg
aatgtggtggtccatgactggctatattactatgcttacaaggactttctctggtttttc
tccaagagattcaaatctgctgccatgttagctgtctttgctgtatctgctgtagtacac
gaatatgccttggctgtttgcttgagctttttctatcccgtgctcttcgtgctcttcatg
ttctttggaatggctttcaacttcattgtcaatgatagtcggaaaaagccgatttggaat
gttctgatgtggacttctcttttcttgggcaatggagtcttactctgcttttattctcaa
gaatggtatgcacgtcagcactgtcctctgaaaaatcccacatttttggattatgtccgg
ccacgttcctggacttgtcgttacgtgttttag
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