KEGG   Homo sapiens (human): 6646
Entry
6646              CDS       T01001                                 
Symbol
SOAT1, ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT
Name
(RefSeq) sterol O-acyltransferase 1
  KO
K00637  sterol O-acyltransferase [EC:2.3.1.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00100  Steroid biosynthesis
hsa04979  Cholesterol metabolism
Drug target
Avasimibe: D03012
Cetaben sodium: D03447
Eldacimibe: D03734
Lecimibide: D03735
Melinamide: D01202
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    6646 (SOAT1)
 09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    6646 (SOAT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.26  sterol O-acyltransferase
     6646 (SOAT1)
SSDB
Motif
Pfam: MBOAT
Other DBs
NCBI-GeneID: 6646
NCBI-ProteinID: NP_003092
OMIM: 102642
HGNC: 11177
Ensembl: ENSG00000057252
UniProt: P35610
Structure
LinkDB
Position
1:179293797..179358680
AA seq 550 aa
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
NT seq 1653 nt   +upstreamnt  +downstreamnt
atggtgggtgaagagaagatgtctctaagaaaccggctgtcaaagtccagggaaaatcct
gaggaagatgaagaccagagaaaccctgcaaaggagtccctagagacacctagtaatggt
cgaattgacataaaacagttgatagcaaagaagataaagttgacagcagaggcagaggaa
ttgaagccattttttatgaaggaagttggcagtcactttgatgattttgtgaccaatctc
attgaaaagtcagcatcattagataatggtgggtgcgctctcacaaccttttctgttctt
gaaggagagaaaaacaaccatagagcgaaggatttgagagcacctccagaacaaggaaag
atttttattgcaaggcgctctctcttagatgaactgcttgaagtggaccacatcagaaca
atatatcacatgtttattgccctcctcattctctttatcctcagcacacttgtagtagat
tacattgatgaaggaaggctggtgcttgagttcagcctcctgtcttatgcttttggcaaa
tttcctaccgttgtttggacctggtggatcatgttcctgtctacattttcagttccctat
tttctgtttcaacattgggccactggctatagcaagagttctcatccgctgatccgttct
ctcttccatggctttcttttcatgatcttccagattggagttctaggttttggaccaaca
tatgttgtgttagcatatacactgccaccagcttcccggttcatcattatattcgagcag
attcgttttgtaatgaaggcccactcatttgtcagagagaacgtgcctcgggtactaaat
tcagctaaggagaaatcaagcactgttccaatacctacagtcaaccagtatttgtacttc
ttatttgctcctacccttatctaccgtgacagctatcccaggaatcccactgtaagatgg
ggttatgtcgctatgaagtttgcacaggtctttggttgctttttctatgtgtactacatc
tttgaaaggctttgtgcccccttgtttcggaatatcaaacaggagcccttcagcgctcgt
gttctggtcctatgtgtatttaactccatcttgccaggtgtgctgattctcttccttact
ttttttgcctttttgcactgctggctcaatgcctttgctgagatgttacgctttggtgac
aggatgttctataaggattggtggaactccacgtcatactccaactattatagaacctgg
aatgtggtggtccatgactggctatattactatgcttacaaggactttctctggtttttc
tccaagagattcaaatctgctgccatgttagctgtctttgctgtatctgctgtagtacac
gaatatgccttggctgtttgcttgagctttttctatcccgtgctcttcgtgctcttcatg
ttctttggaatggctttcaacttcattgtcaatgatagtcggaaaaagccgatttggaat
gttctgatgtggacttctcttttcttgggcaatggagtcttactctgcttttattctcaa
gaatggtatgcacgtcagcactgtcctctgaaaaatcccacatttttggattatgtccgg
ccacgttcctggacttgtcgttacgtgttttag

KEGG   Homo sapiens (human): 8435
Entry
8435              CDS       T01001                                 
Symbol
SOAT2, ACACT2, ACAT2, ARGP2
Name
(RefSeq) sterol O-acyltransferase 2
  KO
K00637  sterol O-acyltransferase [EC:2.3.1.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00100  Steroid biosynthesis
hsa04979  Cholesterol metabolism
Drug target
Avasimibe: D03012
Cetaben sodium: D03447
Eldacimibe: D03734
Lecimibide: D03735
Melinamide: D01202
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    8435 (SOAT2)
 09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    8435 (SOAT2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.26  sterol O-acyltransferase
     8435 (SOAT2)
SSDB
Motif
Pfam: MBOAT MBOAT_2
Other DBs
NCBI-GeneID: 8435
NCBI-ProteinID: NP_003569
OMIM: 601311
HGNC: 11178
Ensembl: ENSG00000167780
UniProt: O75908
Structure
LinkDB
Position
12:53103486..53124535
AA seq 522 aa
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
NT seq 1569 nt   +upstreamnt  +downstreamnt
atggagccaggcggggcccgtctgcgtctgcagaggacagaagggctgggaggggagcgg
gagcgccaaccctgtggagatggaaacactgagacgcacagagccccggacttggtacaa
tggacccgacacatggaggctgtgaaggcacaattgctggagcaagcgcagggacaactg
agggagctgctggatcgggccatgcgggaggctatacaatcctacccatcacaagacaaa
cctctgcccccacctcccccaggttccttgagcaggacccaggagccatccctggggaaa
cagaaagttttcatcatccgcaagtccctgcttgatgagctgatggaggtgcagcatttc
cgcaccatctaccacatgttcatcgctggcctgtgtgtcttcatcatcagcaccctggcc
atcgacttcattgatgagggcaggctgctgctggagtttgacctactgatcttcagcttc
ggacagctgccattggcgctggtgacctgggtgcccatgtttctgtccaccctgttggcg
ccgtaccaggccctacggctgtgggccaggggcacctggacgcaggcgacgggcctgggc
tgtgcgctgctagccgcccacgccgtggtgctctgcgcgctgccggtccacgtggccgtg
gagcatcagctcccgccggcctcccgttgtgtcctggtcttcgagcaggttaggttcctg
atgaaaagctactccttcctgagagaggctgtgcctgggacccttcgtgccagacgaggt
gaggggatccaggcccccagtttctccagctacctctacttcctcttctgcccaacactc
atctacagggagacttaccctaggacgccctatgtcaggtggaattatgtggccaagaac
tttgcccaggccctgggatgtgtgctctatgcctgcttcatcctgggccgcctctgtgtt
cctgtctttgccaacatgagccgagagcccttcagcacccgtgccctggtgctctctatc
ctgcatgccacgttgccaggcatcttcatgctgctgctcatcttctttgccttcctccat
tgctggctcaacgcctttgccgagatgctacgatttggagacaggatgttctaccgggac
tggtggaactcaacgtccttctccaactactaccgcacttggaacgtggtggtccatgac
tggctgtacagctacgtgtatcaggatgggctgcggctccttggtgcccgggcccgaggg
gtagccatgctgggtgtgttcctggtctccgcagtggcccatgagtatatcttctgcttc
gtcctggggttcttctatcccgtcatgctgatactcttccttgtcattggaggaatgttg
aacttcatgatgcatgaccagcgcaccggcccggcatggaacgtgctgatgtggaccatg
ctgtttctaggccagggaatccaggtcagcctgtactgccaggagtggtacgcacggcgg
cactgccccttaccccaggcaactttctgggggctggtgacacctcgatcttggtcctgc
catacctag

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