Homo sapiens (human): 6683
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Entry
6683 CDS
T01001
Symbol
SPAST, ADPSP, FSP2, SPG4
Name
(RefSeq) spastin
KO
K13254
spastin [EC:
5.6.1.1
]
Organism
hsa
Homo sapiens (human)
Network
nt06541
Cytoskeleton in neurons
Element
N01839
Severing of microtubule, SPAST/KATN
Disease
H00266
Hereditary spastic paraplegia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
6683 (SPAST)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
6683 (SPAST)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.1 Enzymes altering polypeptide conformation or assembly
5.6.1.1 microtubule-severing ATPase
6683 (SPAST)
Membrane trafficking [BR:
hsa04131
]
Endoplasmic reticulum (ER) - Golgi transport
Others
Others
6683 (SPAST)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulin-binding proteins
Microtubule severing proteins
6683 (SPAST)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
AAA
AAA_lid_3
Vps4_C
RuvB_N
AAA_5
AAA_22
TIP49
AAA_16
AAA_14
Mg_chelatase
MIT
DUF815
IstB_IS21
AAA_24
nSTAND3
NPHP3_N
AAA_2
DUF4368
Motif
Other DBs
NCBI-GeneID:
6683
NCBI-ProteinID:
NP_055761
OMIM:
604277
HGNC:
11233
Ensembl:
ENSG00000021574
UniProt:
Q9UBP0
E5KRP5
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:32063556..32157637
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AA seq
616 aa
AA seq
DB search
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
MMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLT
HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM
TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT
LEAYIRWNKDFGDTTV
NT seq
1851 nt
NT seq
+upstream
nt +downstream
nt
atgaattctccgggtggacgagggaagaagaaaggctccggcggcgccagcaacccggtg
cctcccaggcctccgcccccttgcctggcccccgcccctcccgccgccgggccggcccct
ccgcccgagtcgccgcataagcggaacctgtactatttctcctacccgctgtttgtaggc
ttcgcgctgctgcgtttggtcgccttccacctggggctcctcttcgtgtggctctgccag
cgcttctcccgcgccctcatggcagccaagaggagctccggggccgcgccagcacctgcc
tcggcctcggccccggcgccggtgccgggcggcgaggccgagcgcgtccgagtcttccac
aaacaggccttcgagtacatctccattgccctgcgcatcgatgaggatgagaaagcagga
cagaaggagcaagctgtggaatggtataagaaaggtattgaagaactggaaaaaggaata
gctgttatagttacaggacaaggtgaacagtgtgaaagagctagacgccttcaagctaaa
atgatgactaatttggttatggccaaggaccgcttacaacttctagagaagatgcaacca
gttttgccattttccaagtcacaaacggacgtctataatgacagtactaacttggcatgc
cgcaatggacatctccagtcagaaagtggagctgttccaaaaagaaaagaccccttaaca
cacactagtaattcactgcctcgttcaaaaacagttatgaaaactggatctgcaggcctt
tcaggccaccatagagcacctagttacagtggtttatccatggtttctggagtgaaacag
ggatctggtcctgctcctaccactcataagggtactccgaaaacaaataggacaaataaa
ccttctacccctacaactgctactcgtaagaaaaaagacttgaagaattttaggaatgtg
gacagcaaccttgctaaccttataatgaatgaaattgtggacaatggaacagctgttaaa
tttgatgatatagctggtcaagacttggcaaaacaagcattgcaagaaattgttattctt
ccttctctgaggcctgagttgttcacagggcttagagctcctgccagagggctgttactc
tttggtccacctgggaatgggaagacaatgctggctaaagcagtagctgcagaatcgaat
gcaaccttctttaatataagtgctgcaagtttaacttcaaaatacgtgggagaaggagag
aaattggtgagggctctttttgctgtggctcgagaacttcaaccttctataatttttata
gatgaagttgatagccttttgtgtgaaagaagagaaggggagcacgatgctagtagacgc
ctaaaaactgaatttctaatagaatttgatggtgtacagtctgctggagatgacagagta
cttgtaatgggtgcaactaataggccacaagagcttgatgaggctgttctcaggcgtttc
atcaaacgggtatatgtgtctttaccaaatgaggagacaagactacttttgcttaaaaat
ctgttatgtaaacaaggaagtccattgacccaaaaagaactagcacaacttgctagaatg
actgatggatactcaggaagtgacctaacagctttggcaaaagatgcagcactgggtcct
atccgagaactaaaaccagaacaggtgaagaatatgtctgccagtgagatgagaaatatt
cgattatctgacttcactgaatccttgaaaaaaataaaacgcagcgtcagccctcaaact
ttagaagcgtacatacgttggaacaaggactttggagataccactgtttaa
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