Homo sapiens (human): 6716 Help Entry 6716              CDS       T01001                                  Symbol SRD5A2 Name (RefSeq) steroid 5 alpha-reductase 2   KO K12344   3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:1.3.1.22] Organism hsa  Homo sapiens (human) Pathway hsa00140   Steroid hormone biosynthesis hsa01100   Metabolic pathways hsa05215   Prostate cancer Module hsa_M00976   C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone Network nt06019  Steroid hormone biosynthesis   Element N01541   Testosterone biosynthesis Disease H00608   46,XY disorder of sex development due to testosterone secretion defect Drug target Alfatradiol:  D07121 Dutasteride:  D03820<JP/US> Epristeride:  D01134 Estramustine (DG00724):  D02398 D04066 D06397<JP/US> Finasteride:  D00321<JP/US> Idronoxil:  D04498 Izonsteride:  D04646 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00140 Steroid hormone biosynthesis     6716 (SRD5A2)  09160 Human Diseases   09162 Cancer: specific types    05215 Prostate cancer     6716 (SRD5A2) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.3  Acting on the CH-CH group of donors    1.3.1  With NAD+ or NADP+ as acceptor     1.3.1.22  3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)      6716 (SRD5A2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Steroid_dh DUF1295 DUF6832 PEMT Motif Other DBs NCBI-GeneID:  6716 NCBI-ProteinID:  NP_000339 OMIM:  607306 HGNC:  11285 Ensembl:  ENSG00000277893 UniProt:  P31213 Structure PDB LinkDB All DBs Position 2:complement(31522480..31663009) Genome browser AA seq 254 aa AA seqDB search MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS FAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCT GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE DYPKSRKALIPFIF NT seq 765 nt NT seq  +upstreamnt  +downstreamnt atgcaggttcagtgccagcagagcccagtgctggcaggcagcgccactttggtcgccctt ggggcactggccttgtacgtcgcgaagccctccggctacgggaagcacacggagagcctg aagccggcggctacccgcctgccagcccgcgccgcctggttcctgcaggagctgccttcc ttcgcggtgcccgcggggatcctcgcccggcagcccctctccctcttcgggccacctggg acggtacttctgggcctcttctgcctacattacttccacaggacatttgtgtactcactg ctcaatcgagggaggccttatccagctatactcattctcagaggcactgccttctgcact ggaaatggagtccttcaaggctactatctgatttactgtgctgaataccctgatgggtgg tacacagacatacggtttagcttgggtgtcttcttatttattttgggaatgggaataaac attcatagtgactatatattgcgccagctcaggaagcctggagaaatcagctacaggatt ccacaaggtggcttgtttacgtatgtttctggagccaatttcctcggtgagatcattgaa tggatcggctatgccctggccacttggtccctcccagcacttgcatttgcatttttctca ctttgtttccttgggctgcgagcttttcaccaccataggttctacctcaagatgtttgag gactaccccaaatctcggaaagcccttattccattcatcttttaa

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