KEGG   Homo sapiens (human): 6869
Entry
6869              CDS       T01001                                 
Symbol
TACR1, NK1R, NKIR, SPR, TAC1R
Name
(RefSeq) tachykinin receptor 1
  KO
K04222  tachykinin receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
Network
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N01640  GPCR-PLCB-ITPR signaling pathway
N01915  Tachykinin receptor signaling
Drug target
Aprepitant (DG00066): D02968<JP/US> D06597<JP/US> D10895
Befetupitant: D03221
Casopitant: D06574
Elinzanetant: D12123
Ezlopitant: D04122
Maropitant citrate: D04860
Netupitant (DG02843): D05152 D11065 D11370<JP>
Orvepitant (DG01315): D09650 D09651
Rolapitant (DG01868): D08988<US> D10742
Serlopitant: D09378
Telmapitant: D10391
Tradipitant: D11728
Vestipitant mesylate: D06293
Vofopitant dihydrochloride: D06317
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    6869 (TACR1)
   04082 Neuroactive ligand signaling
    6869 (TACR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    6869 (TACR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Tachykinin
    6869 (TACR1)
SSDB
Motif
Pfam: 7tm_1 TctB 7tm_4
Other DBs
NCBI-GeneID: 6869
NCBI-ProteinID: NP_001049
OMIM: 162323
HGNC: 11526
Ensembl: ENSG00000115353
UniProt: P25103
Structure
LinkDB
Position
2:complement(75046463..75199520)
AA seq 407 aa
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
NT seq 1224 nt   +upstreamnt  +downstreamnt
atggataacgtcctcccggtggactcagacctctccccaaacatctccactaacacctcg
gaacccaatcagttcgtgcaaccagcctggcaaattgtcctttgggcagctgcctacacg
gtcattgtggtgacctctgtggtgggcaacgtggtagtgatgtggatcatcttagcccac
aaaagaatgaggacagtgacgaactattttctggtgaacctggccttcgcggaggcctcc
atggctgcattcaatacagtggtgaacttcacctatgctgtccacaacgaatggtactac
ggcctgttctactgcaagttccacaacttctttcccatcgccgctgtcttcgccagtatc
tactccatgacggctgtggcctttgataggtacatggccatcatacatcccctccagccc
cggctgtcagccacagccaccaaagtggtcatctgtgtcatctgggtcctggctctcctg
ctggccttcccccagggctactactcaaccacagagaccatgcccagcagagtcgtgtgc
atgatcgaatggccagagcatccgaacaagatttatgagaaagtgtaccacatctgtgtg
actgtgctgatctacttcctccccctgctggtgattggctatgcatacaccgtagtggga
atcacactatgggccagtgagatccccggggactcctctgaccgctaccacgagcaagtc
tctgccaagcgcaaggtggtcaaaatgatgattgtcgtggtgtgcaccttcgccatctgc
tggctgcccttccacatcttcttcctcctgccctacatcaacccagatctctacctgaag
aagtttatccagcaggtctacctggccatcatgtggctggccatgagctccaccatgtac
aaccccatcatctactgctgcctcaatgacaggttccgtctgggcttcaagcatgccttc
cggtgctgccccttcatcagcgccggcgactatgaggggctggaaatgaaatccacccgg
tatctccagacccagggcagtgtgtacaaagtcagccgcctggagaccaccatctccaca
gtggtgggggcccacgaggaggagccagaggacggccccaaggccacaccctcgtccctg
gacctgacctccaactgctcttcacgaagtgactccaagaccatgacagagagcttcagc
ttctcctccaatgtgctctcctag

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