KEGG T01001: 6923

Homo sapiens (human): 6923

Entry

6923              CDS       T01001

Symbol

ELOB, SIII, TCEB2

Name

(RefSeq) elongin B

K03873

elongin-B

Organism

hsa Homo sapiens (human)

Pathway

hsa04066

HIF-1 signaling pathway

hsa04120

Ubiquitin mediated proteolysis

hsa05170

Human immunodeficiency virus 1 infection

hsa05200

Pathways in cancer

hsa05211

Renal cell carcinoma

Network

nt06225  HIF-1 signaling (cancer)
nt06264  Renal cell carcinoma
nt06509  DNA replication
nt06523  Epigenetic regulation by Polycomb complexes
nt06542  HIF signaling

Element

N00080

Loss of VHL to HIF-1 signaling pathway

N00081

Mutation-inactivated VHL to HIF-1 signaling pathway

N01473

DNA replication termination

N01577

Gene silencing by methylation of H3K27 and ubiquitination of H2AK119

N01872

Proteasomal degradation of HIF by VHL complex

N01873

VHL mutation to HIF-2 signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    6923 (ELOB)
09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    6923 (ELOB)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6923 (ELOB)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    6923 (ELOB)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    6923 (ELOB)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    6923 (ELOB)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    6923 (ELOB)
Ubiquitin system [BR:hsa04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul2 complex
    Adoptor protein
     6923 (ELOB)
   Cul5 complex
     6923 (ELOB)
DNA repair and recombination proteins [BR:hsa03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    Other NER factors
     6923 (ELOB)

SSDB

Motif

Pfam:

ubiquitin Rad60-SLD

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

16:complement(2771414..2777280)

AA seq 118 aa
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGEC
GFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ

NT seq 357 nt +upstreamnt +downstreamnt
atggacgtgttcctcatgatccggcgccacaagaccaccatcttcacggacgccaaggag
tccagcacggtgttcgaactgaagcgcatcgtcgagggcatcctcaagcggcctcctgac
gagcagcggctgtacaaggatgaccaactcttggatgatggcaagacactgggcgagtgt
ggcttcaccagtcaaacagcacggccacaggccccagccacagtggggctggccttccgg
gcagatgacacctttgaggccctgtgcatcgagccgttttccagcccgccagagctgccc
gatgtgatgaagccccaggactcgggaagcagtgccaatgaacaagccgtgcagtga

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