Homo sapiens (human): 699
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Entry
699 CDS
T01001
Symbol
BUB1, BUB1A, BUB1L, MCPH30, hBUB1
Name
(RefSeq) BUB1 mitotic checkpoint serine/threonine kinase
KO
K02178
checkpoint serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04110
Cell cycle
hsa04114
Oocyte meiosis
hsa04914
Progesterone-mediated oocyte maturation
Network
nt06515
Regulation of kinetochore-microtubule interactions
Element
N01529
Recruitment and formation of the MCC
N01534
Dynein recruitment to the kinetochore
Disease
H00020
Colorectal cancer
H00269
Primary microcephaly
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
699 (BUB1)
04114 Oocyte meiosis
699 (BUB1)
09150 Organismal Systems
09152 Endocrine system
04914 Progesterone-mediated oocyte maturation
699 (BUB1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
699 (BUB1)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
699 (BUB1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
699 (BUB1)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: Other
BUB family
699 (BUB1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centromeric chromatin formation proteins
SAC (spindle assembly checkpoint) factors
Core SAC proteins
699 (BUB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Mad3_BUB1_I
Pkinase
Mad3_BUB1_I_2
PK_Tyr_Ser-Thr
SNaCT7
Inhibitor_I68
TPR_14
Motif
Other DBs
NCBI-GeneID:
699
NCBI-ProteinID:
NP_004327
OMIM:
602452
HGNC:
1148
Ensembl:
ENSG00000169679
UniProt:
O43683
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:complement(110637528..110678063)
Genome browser
AA seq
1085 aa
AA seq
DB search
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
NT seq
3258 nt
NT seq
+upstream
nt +downstream
nt
atggacaccccggaaaatgtccttcagatgcttgaagcccacatgcagagctacaagggc
aatgaccctcttggtgaatgggaaagatacatacagtgggtagaagagaattttcctgag
aataaagaatacttgataactttactagaacatttaatgaaggaatttttagataagaag
aaataccacaatgacccaagattcatcagttattgtttaaaatttgctgagtacaacagt
gacctccatcaattttttgagtttctgtacaaccatgggattggaaccctgtcatcccct
ctgtacattgcctgggcggggcatctggaagcccaaggagagctgcagcatgccagtgct
gtccttcagagaggaattcaaaaccaggctgaacccagagagttcctgcaacaacaatac
aggttatttcagacacgcctcactgaaacccatttgccagctcaagctagaacctcagaa
cctctgcataatgttcaggttttaaatcaaatgataacatcaaaatcaaatccaggaaat
aacatggcctgcatttctaagaatcagggttcagagctttctggagtgatatcttcagct
tgtgataaagagtcaaatatggaacgaagagtgatcacgatttctaaatcagaatattct
gtgcactcatctttggcatccaaagttgatgttgagcaggttgttatgtattgcaaggag
aagcttattcgtggggaatcagaattttcctttgaagaattgagagcccagaaatacaat
caacggagaaagcatgagcaatgggtaaatgaagacagacattatatgaaaaggaaagaa
gcaaatgcttttgaagaacagctattaaaacagaaaatggatgaacttcataagaagttg
catcaggtggtggagacatcccatgaggatctgcccgcttcccaggaaaggtccgaggtt
aatccagcacgtatggggccaagtgtaggctcccagcaggaactgagagcgccatgtctt
ccagtaacctatcagcagacaccagtgaacatggaaaagaacccaagagaggcacctcct
gttgttcctcctttggcaaatgctatttctgcagctttggtgtccccagccaccagccag
agcattgctcctcctgttcctttgaaagcccagacagtaacagactccatgtttgcagtg
gccagcaaagatgctggatgtgtgaataagagtactcatgaattcaagccacagagtgga
gcagagatcaaagaagggtgtgaaacacataaggttgccaacacaagttcttttcacaca
actccaaacacatcactgggaatggttcaggcaacgccatccaaagtgcagccatcaccc
accgtgcacacaaaagaagcattaggtttcatcatgaatatgtttcaggctcctacactt
cctgatatttctgatgacaaagatgaatggcaatctctagatcaaaatgaagatgcattt
gaagcccagtttcaaaaaaatgtaaggtcatctggggcttggggagtcaataagatcatc
tcttctttgtcatctgcttttcatgtgtttgaagatggaaacaaagaaaattatggatta
ccacagcctaaaaataaacccacaggagccaggacctttggagaacgctctgtcagcaga
cttccttcaaaaccaaaggaggaagtgcctcatgctgaagagtttttggatgactcaact
gtatggggtattcgctgcaacaaaaccctggcacccagtcctaagagcccaggagacttc
acatctgctgcacaacttgcgtctacaccattccacaagcttccagtggagtcagtgcac
attttagaagataaagaaaatgtggtagcaaaacagtgtacccaggcgactttggattct
tgtgaggaaaacatggtggtgccttcaagggatggaaaattcagtccaattcaagagaaa
agcccaaaacaggccttgtcgtctcacatgtattcagcatccttacttcgtctgagccag
cctgctgcaggtggggtacttacctgtgaggcagagttgggcgttgaggcttgcagactc
acagacactgacgctgccattgcagaagatccaccagatgctattgctgggctccaagca
gaatggatgcagatgagttcacttgggactgttgatgctccaaacttcattgttgggaac
ccatgggatgataagctgattttcaaacttttatctgggctttctaaaccagtgagttcc
tatccaaatacttttgaatggcaatgtaaacttccagccatcaagcccaagactgaattt
caattgggttctaagctggtctatgtccatcaccttcttggagaaggagcctttgcccag
gtgtacgaagctacccagggagatctgaatgatgctaaaaataaacagaaatttgtttta
aaggtccaaaagcctgccaacccctgggaattctacattgggacccagttgatggaaaga
ctaaagccatctatgcagcacatgtttatgaagttctattctgcccacttattccagaat
ggcagtgtattagtaggagagctctacagctatggaacattattaaatgccattaacctc
tataaaaatacccctgaaaaagtgatgcctcaaggtcttgtcatctcttttgctatgaga
atgctttacatgattgagcaagtgcatgactgtgaaatcattcatggagacattaaacca
gacaatttcatacttggaaacggatttttggaacaggatgatgaagatgatttatctgct
ggcttggcactgattgacctgggtcagagtatagatatgaaactttttccaaaaggaact
atattcacagcaaagtgtgaaacatctggttttcagtgtgttgagatgctcagcaacaaa
ccatggaactaccagatcgattactttggggttgctgcaacagtatattgcatgctcttt
ggcacttacatgaaagtgaaaaatgaaggaggagagtgtaagcctgaaggtctttttaga
aggcttcctcatttggatatgtggaatgaattttttcatgttatgttgaatattccagat
tgtcatcatcttccatctttggatttgttaaggcaaaagctgaagaaagtatttcaacaa
cactatactaacaagattagggccctacgtaataggctaattgtactgctcttagaatgt
aagcgttcacgaaaataa
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integrated database retrieval system
